Upper respiratory system
nose, nasal cavity, sinuses, and pharynx (down to the epiglottis)
Lower respiratory system
Larynx, trachea, bronchi, bronchioles, lungs, and alveoli
Nose/Nasal Cavity
The entry point for air; nasal conchae creates turbulence to warm, humidify, and filter incoming air. The paranasal sinuses connect to the nasal cavity
Pharynx (throat)
A muscular passageway divided into three regions
- Nasopharynx: posterior to the nasal cavity
- Oropharynx: posterior to the oral cavity
- Laryngopharynx: posterior to the larynx
Bronchi/Bronchioles
The trachea branches into left and right primary bronchi, which enter the lungs and continue to branch into smaller bronchioles
Conducting portion
All structures from the nose/mouth to the terminal bronchioles. This portion filters, warms, and humidifies air but does not perform gas exchange
Gas exchange
Oxygen diffuses from the alveoli into the blood
Carbon dioxide diffuses from the blood into the alveoli
Pseudostratified Ciliated Columnar Epithelium
Specialized respiratory epithelium that lines the conducting portion; coated with a sticky mucus
Mucociliary elevator
Cilia constantly beat in a coordinated wave, moving the mucus and any trapped debris and pathogens upward toward the pharynx; prevents contaminants from reaching the delicate lungs
Type I Alveolar Cells
Thin, squamous epithelial cells that form the primary structure of the alveolar wall; main sites of gas exchange
Type II Alveolar Cells
Provide surfactant, a detergent-like substance that reduces surface tension and prevents the alveoli from collapsing after exhalation
Bronchial arteries
Supplies the lungs with oxygenated blood
Visceral Pleura
Inner layer that directly covers the surface of the lungs
Pleural Cavity
Houses the lungs; contains a small amount of pleural fluid that reduces friction during breathing
Parietal Pleura
The outer layer that lines the inside of the thoracic wall, the mediastinum, and the superior surface of the diaphragm
Pulmonary Ventiliation
Breathing, involves a pressure gradient between the atmosphere and the alveoli
Primary muscles in puliminary ventilation
Diaphragm and intercostal muscles
Inhalation
The diaphragm contracts and flattens
The external intercostal muscles contract, lifting the ribcage
Increased volume of thoracic cavity
Decreased intra-pulmonary pressure below atmospheric pressure
Exhalation
Diaphragm and external intercostal muscles relax
Thoracic cavity volume decreases
Increased intra-pulmonary pressure above atmospheric pressure
Medulla Oblongata
In the brainstem; acts as the central respiratory center
How medulla determines respiratory
Central and Peripheral Chemoreceptors, stretch receptors in the lungs, proprioceptors in muscles and joints
Major plasma proteins
Albumins, Globulins, and Fibrinogen
Albumins
Transport fatty acids, thyroid hormones, and steroids
Globulins
Immunoglobulins and transport globulins
Fibrinogen
Clot formation
Base
Broad, superior part of the heart where major vessels attach
Apex
The pointed, inferior portion of the heart
Heart wall layers
Endocardium, Myocardium (contracts), epicardium
Pericardium
Double-wall sac that encloses the heart
Parietal pericardium = outer layer; epicardium = inner layer
Pulmonary circuit
Carries blood between the heart and the lungs (right atrium --> left atrium)
Systemic circuit
Carries blood between the heart and the rest of the body (Left atrium --> right atrium)
AV node
Relays and intensifies the impulse from the SA node, introducing a slight delay to allow the atria to contract fully
Bundle of His/AV Bundle
Conducts the impulse from the AV node toward the ventricles
Purkinje fibers
Spread the impulse throughout the ventricular myocardium, causing the ventricles to contract
Sympathetic Influence
Releases catecholamines (epinephrine, norepinephrine)
Causes a positive chronotropic effect (increased heart rate)
Causes a positive inotropic effect (increased force of contraction)
Parasympathetic Influence
Releases acetylcholine
Causes a negative chronotropic effect
Causes a negative inotropic effect
Primarily via the vagus nerve
Capacitance vessels
systemic veins; hold most of the blood
Command center of the endocrine system
The hypothalamus and pituitary gland
Hypothalamus linking nervous and endocrine system as an endocrine organ
Hypothalamic neurons produce antidiuretic hormone (ADH) and oxytocin (OXT). These hormones travel along axons to the posterior pituitary, where they are stored and released into the bloodstream. These are called neurosecretions
Hypothalamus linking nervous and endocrine system by secreting regulatory hormones
The hypothalamus produces releasing and inhibitory hormones that control the anterior pituitary. There, regulatory hormones travel via a specialized blood vessel network called the hypophyseal portal system to precisely regulate the anterior pituitary's hormone release
Hypothalamus linking nervous and endocrine system: containing autonomic centers
Autonomic centers in the hypothalamus exert nervous control over the adrenal medulla, influencing the release of epinephrine and norepinephrine
Thyroid Gland
Located anterior to the trachea
Produces Thyroxine (T4) and Triiodothyronine (T3) which regulates metabolic rate
Produces Calcitonin (CT) which lowers blood calcium levels by inhibiting osteoclast activity
Parathyroid Glands
Four small glands embedded on the posterior surface of the thyroid
Produce Parathyroid Hormone (PTH) which raises blood calcium levels by stimulating osteoclasts, reducing calcium loss in urine, and promoting calcium absorption in the intestines via vitamin D activation
Adrenal glands regions
Medulla and Cortex
Adrenal Medulla
Part of the sympathetic nervous system
Produces epinephrine and norepinephrine
Adrenal Cortex
Produces cortisol, aldosterone (regulates blood pressure), and androgens (sex hormones)
Pancreatic islets
Performs the endocrine role of the pancreas
Pancreatic alpha cells
secrete glucagon: raises blood glucose levels
Pancreatic beta cells
Secrete insulin: lowers blood glucose levels
Pancreatic delta cells
Secrete somatostatin: inhabits the secretion of both glucagon and insulin, slowing nutrient absorption
Pancreatic PP Cells
Secrete pancreatic polypeptide, which inhibits gallbladder contractions and regulates some pancreatic enzymes
Heart
Produces Atrial Natriuretic Peptide (ANP) and Brain Natriuretic Peptide (BNP) in response to high blood pressure; inhibits ADH and aldosterone to lower blood pressure
Kidneys
Produce Erythropoietin (EPO) in response to low oxygen levels, which stimulates red blood cell production
Produces Renin, which raises blood pressure
Converts vitamin D into its active form calcitriol
Pineal Gland
Located in the epithalamus of the brain; produces melatonin
Adipose tissue
Produces leptin (appetite/fat storage) and resistin (insulin resistance)
System that remains relatively stable with age compared to other systems
Endocrine