A: rapidly and almost completely absorbed from the stomach and small intestine
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D: widely distributed into most body tissues and fluids
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M: prodrug=active metabolite is salicylate.
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It is hydrolyzed to salicylate in the mucosa of the GI tract and on first pass through the liver.
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E: Other metabolites and some salicylate is excreted unchanged in urine.
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Salicylates:
Pharmacologic Effects
■Analgesic: relieves mild to moderate pain such as arthritis, headache, or toothache.
■Antipyretic: reduces fever; no effect on normal body temperature
■Antiinflammatory : causes decreased erythema ( vasodilation) and swelling
■Uricosuric: large doses produce increase in uric acid secretion in urine; small doses of aspirin produce uric acid retention.
■Antiplatelet: irreversibly binds to platelets, results in reduced clotting