BMED 4280 CFUs Flashcards


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1

Common circuit motifs that mediate the spinal stretch reflex include all of the following EXCEPT:

lateral inhibition

2

The process by which a neuron summates synaptic excitation and inhibition is called:

integration

3

The network motif that underlies circadian rhythms is:

feedback inhibition

4

An auto-association network is important for:

memory

5

Drug X, when applied to a nerve axon, results in both a gradual decrease in the amplitude of individual action potentials and a depolarization of the resting potential, both of which develop over a period of several hours. The drug is most likely:

Blocking the (Na+ -K+) pump

6

If a nerve membrane suddenly became equally permeable to both Na+ and K+, the membrane potential would:

approach a value of about 0 mV

7

If the concentration of K+ in the cytoplasm of an invertebrate axon is changed to a new value of 200 mM (Note: for this axon normal [K]o = 20 mM and normal [K]i = 400 mM):

The K+ equilibrium potential would be about -60 mV

8

An endplate potential in a skeletal muscle cell could in principle be produced by a decreased permeability to which of the following ions(s)? (Assume that there is a finite initial permeability to each of the ions listed below and that physiological concentration gradients are present.):

K+

9

In a normal, healthy individual the number of ACh-sensitive channels in a skeletal muscle cell opened as a result of a single action potential in a motor axon would be approximately...

100,000

10

An isolated nerve muscle preparation treated with a moderate dose of curare would be associated with a decrease in the (NOTE: there is more than one correct answer.)

amplitude of MEPPs

amplitude of the EPP

11

An isolated nerve muscle preparation exposed to a low concentration of extracellular Ca2+ would be associated with a decrease in the (NOTE: there is more than one correct answer.)

amplitude of the EPP

release of transmitter from the terminal of the motor axon triggered by a presynaptic action potential

influx of Ca2+ into the presynaptic terminal

12

Which of the following cell types proliferate in the CNS in response to injury? (Note: There is more than one correct answer.)

Microglia

Fibrous astrocytes

Protoplasmic astrocytes

Macrophages

(NOT neurons)

13

Which of the following cell types is responsible for the maintenance of pH of the extracellular space of the CNS? (Note: There is more than one correct answer.)

Fibrous astrocytes

Protoplasmic astrocytes

14

All of the following are guidance cues for axonal outgrowth and pathfinding EXCEPT:

filopodia

15

Agrin:

is a nerve derived factor

16

Which of the following is a guidance cue for axonal outgrowth and pathfinding?

Fasciculation

17

Synapses...

are eliminated if they are not active

18

Which of the following processes dictate the amount of neurotransmitter released from a nerve ending on a short-term, minute-to-minute, basis? (NOTE: there is more than one correct answer.)

neurotransmitter synthesis

vesicle recycling in the nerve ending

calcium availability

19

match the receptor and sensation

Golgi Tendon Organ

Muscle tension

20

match the receptor and sensation

meissner corpuscle

flutter

21

match the receptor and sensation

merkel complex

fine touch

22

match the receptor and sensation

free nerve endings

pain

23

match the receptor and sensation

pacinian corpuscle

vibration

24

C fibers

dull, burning pain

25

A-delta fibers

sharp "fast" pain

26

A-beta fibers

vibration

27

. The neospinothalamic tract crosses the midline in which of the following structures?

anterior white commissure

28

The medial lemniscus crosses the midline at which level of the nervous system?

medulla

29

All of the following are released in response to noxious stimulation at the damaged site(s) EXCEPT:

dopamine

30

C fibers transmit which type of pain?

burning pain

31

C fibers are...

small unmyelinated fibers which carry burning pain

32

Aspirin acts to block the formation of..

prostaglandins

33

A-delta fibers transmit primarily

pricking localized pain information

34

Pain receptors/nociceptors are

free nerve endings

35

Double pain sensation results from

two different fibers which conduct the impulses at different velocities

36

A-delta fibers transmit which type of pain to VPL

pricking pain

37

Sharp pain, induced by a skin cut for example, is classified by

pricking pain

38

Mr. John Thomas experiences visceral pain around the upper left lung. All of the following carry this nociceptive information EXCEPT the:

neospinothalamic tract

39

A surgeon attempting to treat chronic pain from the pelvic region will suggest to make a lesion in the:

anterior lateral funiculus

40

In Brown-Sequard syndrome:

kinesthetic and tactile senses are lost ipsilaterally below the lesion

41

sharp localized pain is transmitted by

neospinothalamic tract

42

pain impulses arising within the abdominal and thoracic cavities may reach the CNS by:

somatic nerves innervating

sympathetic nerves

parasympathetic nerves

none of the above

all of the above

all of the above

43

At the level of the ventral trigeminothalamic tract, pain fibers are generally crossed or uncrossed?

Crossed

44

Cell bodies of first order pelvic visceral pain fibers are found in

dorsal root ganglion

45

The following pathway is sectioned in a chordotomy for the treatment of pain:

lateral spinothalamic tract

46

according to the descending pain suppression theory..

pain stimuli activate descending fibers in the dorsolateral fasciculus

47

the melzack-wall gate theory refers to:

non-noxious input suppresses pain at the spinal cord

48

electrical stimulation in the periaqueducatal gray elicits:

analgesia

49

the following nuclei are involved in the serotonergic descending modulation system of pain:

raphe nuclei

50

All of the following is characteristic of the cornea of the eye EXCEPT:

cataracts are formed when it is damaged

51

Which of the following account for the ability of rod bipolar cells to detect and signal light at lower illumination levels than cone bipolar cells?

the rod bipolar cells are denser than the cone bipolar cells projections

52

Which of the following are characteristic of the primary visual cortex "blob" neurons? They:

have color opponent receptive fields

53

Make the best match between the listed condition and the visual field defect.

occlusion of the left posterior cerebral artery

contralesional homonymous hemianopia with macular sparing

54

Make the best match between the below listed condition and the visual field defect.

trauma to the left temporal lobe

contralesional superior quadrantanopia with macular sparing

55

Make the best match between the below listed condition and the visual field defect.

lesion of the optic chiasm

bitemporal hemianopia

56

Which of the basal ganglia nuclei receive direct cortical input?

caudate and putamen

57

All of the following statements about the basal ganglia are correct EXCEPT:

A. The net effect of excitation of the direct pathway is to inhibit cortex.

B. Dopaminergic neurons of the substantia nigra signal unexpected reward or unexpected absence of reward.

C. The basal ganglia have both motor and cognitive functions.

D. The subthalamic nucleus is the origin of the only purely excitatory pathway within the basal ganglia intrinsic circuitry.

E. Parkinson's disease results from damage to the basal ganglia

A. the net effect of excitation of the direct pathway is to inhibit the cortex

58

The spinocerebellum contains the...

vermis and intermediate zone of the anterior and posterior lobes

59

The lateral vestibular nuclei are functionally analogous to the...

deep cerebelalr nuclei

60

The postcommissural fornix projects to which structure?

mamillary bodies

61

Which structure is NOT part of the Papez circuit?

ventral nucleus of the thalamus