Common circuit motifs that mediate the spinal stretch reflex include all of the following EXCEPT:
lateral inhibition
The process by which a neuron summates synaptic excitation and inhibition is called:
integration
The network motif that underlies circadian rhythms is:
feedback inhibition
An auto-association network is important for:
memory
Drug X, when applied to a nerve axon, results in both a gradual decrease in the amplitude of individual action potentials and a depolarization of the resting potential, both of which develop over a period of several hours. The drug is most likely:
Blocking the (Na+ -K+) pump
If a nerve membrane suddenly became equally permeable to both Na+ and K+, the membrane potential would:
approach a value of about 0 mV
If the concentration of K+ in the cytoplasm of an invertebrate axon is changed to a new value of 200 mM (Note: for this axon normal [K]o = 20 mM and normal [K]i = 400 mM):
The K+ equilibrium potential would be about -60 mV
An endplate potential in a skeletal muscle cell could in principle be produced by a decreased permeability to which of the following ions(s)? (Assume that there is a finite initial permeability to each of the ions listed below and that physiological concentration gradients are present.):
K+
In a normal, healthy individual the number of ACh-sensitive channels in a skeletal muscle cell opened as a result of a single action potential in a motor axon would be approximately...
100,000
An isolated nerve muscle preparation treated with a moderate dose of curare would be associated with a decrease in the (NOTE: there is more than one correct answer.)
amplitude of MEPPs
amplitude of the EPP
An isolated nerve muscle preparation exposed to a low concentration of extracellular Ca2+ would be associated with a decrease in the (NOTE: there is more than one correct answer.)
amplitude of the EPP
release of transmitter from the terminal of the motor axon triggered by a presynaptic action potential
influx of Ca2+ into the presynaptic terminal
Which of the following cell types proliferate in the CNS in response to injury? (Note: There is more than one correct answer.)
Microglia
Fibrous astrocytes
Protoplasmic astrocytes
Macrophages
(NOT neurons)
Which of the following cell types is responsible for the maintenance of pH of the extracellular space of the CNS? (Note: There is more than one correct answer.)
Fibrous astrocytes
Protoplasmic astrocytes
All of the following are guidance cues for axonal outgrowth and pathfinding EXCEPT:
filopodia
Agrin:
is a nerve derived factor
Which of the following is a guidance cue for axonal outgrowth and pathfinding?
Fasciculation
Synapses...
are eliminated if they are not active
Which of the following processes dictate the amount of neurotransmitter released from a nerve ending on a short-term, minute-to-minute, basis? (NOTE: there is more than one correct answer.)
neurotransmitter synthesis
vesicle recycling in the nerve ending
calcium availability
match the receptor and sensation
Golgi Tendon Organ
Muscle tension
match the receptor and sensation
meissner corpuscle
flutter
match the receptor and sensation
merkel complex
fine touch
match the receptor and sensation
free nerve endings
pain
match the receptor and sensation
pacinian corpuscle
vibration
C fibers
dull, burning pain
A-delta fibers
sharp "fast" pain
A-beta fibers
vibration
. The neospinothalamic tract crosses the midline in which of the following structures?
anterior white commissure
The medial lemniscus crosses the midline at which level of the nervous system?
medulla
All of the following are released in response to noxious stimulation at the damaged site(s) EXCEPT:
dopamine
C fibers transmit which type of pain?
burning pain
C fibers are...
small unmyelinated fibers which carry burning pain
Aspirin acts to block the formation of..
prostaglandins
A-delta fibers transmit primarily
pricking localized pain information
Pain receptors/nociceptors are
free nerve endings
Double pain sensation results from
two different fibers which conduct the impulses at different velocities
A-delta fibers transmit which type of pain to VPL
pricking pain
Sharp pain, induced by a skin cut for example, is classified by
pricking pain
Mr. John Thomas experiences visceral pain around the upper left lung. All of the following carry this nociceptive information EXCEPT the:
neospinothalamic tract
A surgeon attempting to treat chronic pain from the pelvic region will suggest to make a lesion in the:
anterior lateral funiculus
In Brown-Sequard syndrome:
kinesthetic and tactile senses are lost ipsilaterally below the lesion
sharp localized pain is transmitted by
neospinothalamic tract
pain impulses arising within the abdominal and thoracic cavities may reach the CNS by:
somatic nerves innervating
sympathetic nerves
parasympathetic nerves
none of the above
all of the above
all of the above
At the level of the ventral trigeminothalamic tract, pain fibers are generally crossed or uncrossed?
Crossed
Cell bodies of first order pelvic visceral pain fibers are found in
dorsal root ganglion
The following pathway is sectioned in a chordotomy for the treatment of pain:
lateral spinothalamic tract
according to the descending pain suppression theory..
pain stimuli activate descending fibers in the dorsolateral fasciculus
the melzack-wall gate theory refers to:
non-noxious input suppresses pain at the spinal cord
electrical stimulation in the periaqueducatal gray elicits:
analgesia
the following nuclei are involved in the serotonergic descending modulation system of pain:
raphe nuclei
All of the following is characteristic of the cornea of the eye EXCEPT:
cataracts are formed when it is damaged
Which of the following account for the ability of rod bipolar cells to detect and signal light at lower illumination levels than cone bipolar cells?
the rod bipolar cells are denser than the cone bipolar cells projections
Which of the following are characteristic of the primary visual cortex "blob" neurons? They:
have color opponent receptive fields
Make the best match between the listed condition and the visual field defect.
occlusion of the left posterior cerebral artery
contralesional homonymous hemianopia with macular sparing
Make the best match between the below listed condition and the visual field defect.
trauma to the left temporal lobe
contralesional superior quadrantanopia with macular sparing
Make the best match between the below listed condition and the visual field defect.
lesion of the optic chiasm
bitemporal hemianopia
Which of the basal ganglia nuclei receive direct cortical input?
caudate and putamen
All of the following statements about the basal ganglia are correct EXCEPT:
A. The net effect of excitation of the direct pathway is to inhibit cortex.
B. Dopaminergic neurons of the substantia nigra signal unexpected reward or unexpected absence of reward.
C. The basal ganglia have both motor and cognitive functions.
D. The subthalamic nucleus is the origin of the only purely excitatory pathway within the basal ganglia intrinsic circuitry.
E. Parkinson's disease results from damage to the basal ganglia
A. the net effect of excitation of the direct pathway is to inhibit the cortex
The spinocerebellum contains the...
vermis and intermediate zone of the anterior and posterior lobes
The lateral vestibular nuclei are functionally analogous to the...
deep cerebelalr nuclei
The postcommissural fornix projects to which structure?
mamillary bodies
Which structure is NOT part of the Papez circuit?
ventral nucleus of the thalamus