Cardiac Meds Drug Interactions Flashcards

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created 10 months ago by AmazingReign
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These note cards are intended to be used as a tool for memorizing general information about commonly used drugs in paramedicine. They do not replace your standing orders nor protocols for your service in anyway. Best suited for students preparing for written exams.
updated 8 months ago by AmazingReign
Subjects:
paramedic pharmacology
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1

Adenosine

Drug Interactions:

  • Methylxanthines (theophylline-like drugs) antagonize the effects.
  • Dipyridamole (Persantine) potentiates the effects.
  • Carbamazepine (Tegretol) may potentate the AV Node blocking effects.

2

Amiodarone (Cordarone)

Drug Interactions:

  • Incompatible with Sodium Bicarbonate: will precipitate.

3

Aspirin (ASA)

Drug Interactions:

Use with caution in patients allergic to NSAIDS.

  • Ibuprofen
  • Ketoprofen
  • Flurbiprofen
  • Tolmetin
  • Naproxen
  • Ketorolac (Toradol)

4

Atropine sulfate

Drug Interactions:
Effects enhanced by

  • Antihistamines
  • Antipsychotics
  • Benzodiazepines
  • Antidepressants

5

Calcium chloride

Drug Interactions:

  • Sodium Bicarbonate: Do not mix in running IV, flush prior to administration in same IV line.
  • Digitalis: May worsen dysrhythmias in patients on Digitalis.
  • Verapamil: May antagonize effects of Verapamil.

6

Diltiazem (Cardizem)

Drug Interactions:

  • Caution in patients using medications that affect cardiac contractility.
  • In general, should not be used in patients on Beta-blockers.

7

Dopamine (Intropin)

Drug Interactions:

  • Incompatible in alkaline solutions.
  • Beta blockers may antagonize effects.

8

Epinephrine

Drug Interactions:

  • Potentates other sympathomimetics.
  • Deactivated by alkaline solutions.
  • MAOIs may potentate effects of epinephrine.

9

Fentanyl citrate (Sublimaze)

Drug Interactions:

 Many Rx interactions use with caution in conjunction with other opioid, narcotic, or CNS depressant medications.

10

Furosemide (Lasix)

Drug Interactions:

  • Lithium toxicity may be potentiated by sodium depletion.
  • Digitalis toxicity may be potentiated by potassium depletion.

11

Lidocaine (Xylocaine)

Drug Interactions:

  • Apnea induced with succinylcholine may be prolonged with high doses.
  • Cardiac depression may occur in conjunction with IV Dilantin.
  • Metabolic clearance decreased in patients with liver disease or those patients' taking beta-blockers.

12

Magnesium sulfate

Drug Interactions:

  • May enhance effects of other CNS depressants.
  • Serious changes in overall cardiac function may occur with cardiac glycosides.

13

Metoprolol (Lopressor/Toprol XL)

Drug Interactions:

  • Drugs which slow AV conduction ( digoxin): effects may be additive with beta-blockers.
  • Glucagon: Metoprolol may blunt the hyperglycemic action of glucagon.
  • Verapamil or diltiazem may have synergistic or additive pharmacological effects when taken concurrently with beta-blockers; avoid concurrent I.V. use.

14

Morphine sulfate

Drug Interactions:

  • CNS depressant may potentate effects.

15

Nitroglycerin (Nitrolingual/NitroQuick/Nitro-Dur)

Drug Interactions:

  • Additive effects with other vasodilators.

16

Norepinephrine

Drug Interactions:

  • Can be deactivated by alkaline solutions.
  • Sympathomimetic and phosphodiesterase inhibitors may exacerbate dysrhythmias.

17

Oxygen

None.

18

Sodium Bicarbonate

Drug Interactions:

  • May precipitate in calcium solutions.
  • Vasopressors may be deactivated.