ORGANS FORMING THE RESPIRATORY PASSAGEWAYS IN DESCENDING ORDER
- Nose
- Nasal cavity
- Paranasal sinuses
- Pharynx
- Larynx
- Trachea
- Bronchi (their smaller branches)
- Lungs contain alveoli.
CONDUCTING ZONE STRUCTURES
nose, pharynx, larynx, trachea, bronchi, and bronchioles form a continuous passageway for air to move in and out of the lungs
RESPIRATORY ZONE STRUCTURS
terminal bronchioles and alveoli involved in gas exchange
RHINITIS
inflamed nasal mucosa
SINUSITIS
inflamed sinuses; headache
DEVIATED SEPTUM
nasal septum is significantly displaced to one side, making one nasal air passage smaller than the other
WHY IS IT BETTER TO BREATHE THROUGH NOSE THAN MOUTH?
- Purifies
- Humidifies
- Warms
RESPIRATORY MEMBRANE
Single layer of squamous epithelium
- SQUAMOUS
- CUBOIDAL
TYPE I (SQUAMOUS CELLS)
Thin layer that is needed for exchange
TYPE II (CUBOIDAL CELLS)
- secrete surfactant
- removes surface tension, thus preventing collapsing of alveoli
LARYNX STRUCTURE
formed by 9 cartilages: 3 single & 3 paired
- epiglottis
- thyroid cartilage
- cricoid cartilage
- arytenoid cartilages
- corniculate cartilages
- cuneiform cartilages
LUNGS STRUCTURE
2 lungs occupy large part of thoracic cavity
- L: 2 lobes & smaller
- R: 3 lobes
PLEURAE STRUCTURE
two membranes surround each lung:
- inner visceral pleura
- outer parietal pleura
ALVEOLAR CELLS
- Type 1 - SIMPLE
- Type 2 - CUBIDOIL
- Alveolar macrophages - DUST CELLS
SURFACTANTS
A fluid produced by
- Type II alveolar cells
- alveoli
- smallest bronchioles
SURFACTANTS FUNCTION
to lower the surface tension at the air/liquid interface within the alveoli of the lung
FOUR EVENTS OF RESPIRATION
- PULMONARY VENTILATION (BREATHING)
- EXTERNAL RESPIRATION
- TRANSPORT GASES IN BLOOD
- INTERNAL RESPIRATION
PULMONARY VENTILATION (BREATHING)
air goes in and out of lungs
EXTERNAL RESPIRATION
gas exchange in lungs between alveolar air and blood
TRANSPORT GASES IN BLOOD
carrying gases between lungs and body tissues
INTERNAL RESPIRATION
gas exchange between blood and tissues
DALTON'S LAW OF PARTIAL PRESSURES
total pressure exerted by a mixture of gases = to the sum of the partial pressures of the gases in the mixture
HENRY'S LAW
A gas will dissolve in a liquid in proportion to its partial pressure
ex: bubbles in soda
BOYLE'S LAW
a gas's pressure and volume are inversely proportional
INSPIRATION (INHALATION)
diaphragm muscle contracts -> thoracic cavity expands in superior-inferior direction
external intercostal muscles contracts -> rib cages move out and up; thoracic expands in anterior-posterior direction
EXPIRATION (EXHALATION)
- Passive process
- Diaphragm and external intercostal muscles relax = pressure is more
functional importance of the partial vacuum that exists in the intrapleural space
the vacuum would stop removing fluids which would fill the pleural cavity up, making it a positive pressure when it is supposed to maintain a neg pressure
ATELECTESIS
Condition in which all or part of your lung becomes airless and collapse
PLEURISY
Inflammation of the pleura, or membranes, of the lungs
7 FACTORS INFLUENCE PULMONARY VENTILATION
...
COPDS
Chronic Obstructive Pulmonary Disease
- life threatening disease
- airflow limitation that is not fully reversible
EMPHYSEMA
Destruction of alveoli and their permanent enlargement
- can develop empty spaces in lungs
CHRONIC BRONCHITIS
Inflammation of the airways over a long periods of time
- irritation
- excessive mucus
ASTHMA
Cause: airways of lungs to swell and narrow
- wheezing
- shortness of breath
- chest tightness
TUBERCULOSIS
Infection by mycobacterium tuberculosis
LUNG CANCER
Leading cause of cancer death
RESPIRATORY RATE
- # of breaths a person takes within a specified amount of times
- measured in breaths per minute
EUPNEA
Normal breathing
4 RESPIRATORY CONTROL CENTERS IN THE BRAIN
2 in medulla & 2 in pons
MEDULLARY RESPIRATORY CENTERS
- DORSAL RESPIRATORY GROUP
- VENTRAL RESPIRATORY GROUP
DORSAL RESPIRATORY GROUP
- inspiratory center
- send impulses via phrenic and intercostal nerves
- set basic rhythm of breathing
VENTRAL RESPIRATORY GROUP
- work mainly during forceful breathing
PONS RESPIRATORY CENTERS
- APNEUSTIC CENTER
- PNEUMOTAXIC CENTER
APNEUSTIC CENTER
- Stimulates DRG
PNEUMOTAXIC CENTER
- Inhibits apneustic center & DRG: limits length of inspiration and promotes expiration
CO2 TRANSPORT IN BLOOD
- Dissolve in plasma- 7%
- Bound to hemoglobin- 23%
- As bicarbonates in plasma- 70%
O2 TRANSPORT IN BLOOD
- 98.5% is bound to hemoglobin in RBCS
- 1.5% dissolved in plasma
CHLORIDE SHIFT
mass movement of chloride ions into the red blood cells, to balance charges
CARBONIC ANHYDRASE
enzyme present in RBCs convert carbondioxide to bicarbonate ions and carbonic acid in lungs
BOHR’S LAW
hemo-oxy break down faster in low pH,high acidity
HALDANE’S LAW
Less Hb saturation with O2 -> more CO2 transport
OXYGEN-HEMOGLOBIN DISSOCIATION CURVE
A graphical representation of the relationship between:
- hemoglobin's % saturation
- the partial pressure of oxygen
DEAD SPACE
the volume of ventilated air that does not participate in gas exchange