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15 BMD 430 lecture 15

front 1

1. Which of the following is not one of the six antibody effector functions?

A. Neutralization

B. Complement activation

C. DNA repair

D. Opsonization

back 1

C. DNA repair

front 2

2. Which antibody isotype is most abundant in secretions and provides mucosal immunity?

A. IgE

B. IgA

C. IgG

D. IgM

back 2

B. IgA

front 3

3. Which antibody is involved in allergic reactions and defense against parasites?

A. IgG

B. IgA

C. IgE

D. IgD

back 3

C. IgE

front 4

4. Which antibody is pentameric and most effective at complement activation?

A. IgA

B. IgE

C. IgM

D. IgG

back 4

C. IgM

front 5

5. Which antibody is primarily membrane-bound and acts as a B-cell receptor along with IgM?

A. IgE

B. IgG

C. IgA

D. IgD

back 5

D. IgD

front 6

6. Which antibody is the most diverse, present in several subclasses, and reflects the maturation of the immune response

A. IgA

B. IgE

C. IgG

D. IgM

back 6

C. IgG

front 7

7. Fcγ receptors (FcγRs) bind to which antibody class?

A. IgA

B. IgG

C. IgE

D. IgM

back 7

B. IgG

front 8

8. Which Fc receptor is primarily expressed on granulocytes and triggers degranulation?

A. FcγR

B. FcεR

C. FcαR

D. FcμR

back 8

B. FcεR

front 9

9. Which Fc receptor is involved in the regulation of cell activation and binds to IgM?

A. FcγR

B. FcμR

C. FcαR

D. FcεR

back 9

B. FcμR

front 10

10. Which Fc receptor is inhibitory and helps turn off antibody secretion by B cells?

A. FcγRI

B. FcγRIIb (CD32)

C. FcεRI

D. FcαR

back 10

B. FcγRIIb (CD32)

front 11

11. Which therapeutic antibody targets CD20 and is used for B-cell non-Hodgkin’s lymphoma?

A. Adalimumab

B. Rituximab

C. Ipilimumab

D. Infliximab

back 11

B. Rituximab

front 12

12. Adalimumab is a fully human antibody that targets:

A. CTLA-4

B. CD20

C. TNF

D. IL-2

back 12

C. TNF

front 13

13. Which therapeutic antibody targets CTLA-4 to treat metastatic melanoma?

A. Rituximab

B. Ipilimumab

C. Adalimumab

D. Nivolumab

back 13

B. Ipilimumab

front 14

14. Which phase of the CD8+ cytotoxic T cell response occurs in secondary lymphoid tissue?

A. Recognition

B. Apoptosis

C. Activation and differentiation

D. Perforin release

back 14

C. Activation and differentiation

front 15

15. What type of cell is known as a “killer cell” that eliminates infected or abnormal host cells?

A. B cell

B. NK cell

C. Helper T cell

D. Plasma cell

back 15

B. NK cell

front 16

16. IgA can fix complement and induce inflammation.

back 16

false

front 17

17. IgM has low affinity but high avidity due to its pentameric structure.

back 17

true

front 18

18. FcεR receptors are found on mast cells and basophils.

back 18

true

front 19

19. CD40/CD40L interaction is essential for dendritic cell licensing.

back 19

true

front 20

20. CTLs can induce apoptosis through Fas/FasL interaction and granzyme release.

back 20

true

front 21

21. List the six antibody effector functions.

back 21

Neutralization, ADCC, Agglutination, Opsonization, Degranulation, Complement Activation.

front 22

22. Describe one function and characteristic of IgA and IgE.

back 22

IgA: mucosal defense, dimeric, no complement.
  IgE: allergy/parasites, binds FceR, causes degranulation.

front 23

23. What are Fc receptors and what is their general purpose?

back 23

Fc receptors bind antibody Fc regions to mediate effector functions like phagocytosis or degranulation

front 24

24. Explain the role of FcγRIIb (CD32) in immune regulation.

back 24

FcγRIIb (CD32) is inhibitory; turns off B-cell activation and antibody secretion.

front 25

25. Define DC licensing and explain how it involves CD40/CD40L.

back 25

DC licensing: CD4+ T cells activate DCs via CD40/CD40L so DCs can activate CD8+ T cells.

front 26

26. What are the three signals required for CTL activation?

back 26

(1) TCR–MHC I recognition, (2) CD28–CD80/86 costimulation, (3) IL-2–IL-2R signaling.

front 27

27. Compare the missing-self model and the balanced-signals model for NK cell activation.

back 27

Missing-self: NK kills when MHC I absent; Balanced-signals: integrates activating + inhibitory signals (more likely correct).

front 28

28. Define ADCC and describe how NK cells use this process.

back 28

ADCC: antibodies tag target; NK cells bind via Fc receptors and kill tagged cell