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15 BMD 430 lecture 15

front 1

1. Which of the following is not one of the six antibody effector functions?

A. Neutralization

B. Complement activation

C. DNA repair

D. Opsonization

back 1

C. DNA repair

front 2

2. Which antibody isotype is most abundant in secretions and provides mucosal immunity?

A. IgE

B. IgA

C. IgG

D. IgM

back 2

B. IgA

front 3

3. Which antibody is involved in allergic reactions and defense against parasites?

A. IgG

B. IgA

C. IgE

D. IgD

back 3

C. IgE

front 4

4. Which antibody is pentameric and most effective at complement activation?

A. IgA

B. IgE

C. IgM

D. IgG

back 4

C. IgM

front 5

5. Which antibody is primarily membrane-bound and acts as a B-cell receptor along with IgM?

A. IgE

B. IgG

C. IgA

D. IgD

back 5

D. IgD

front 6

6. Which antibody is the most diverse, present in several subclasses, and reflects the maturation of the immune response

A. IgA

B. IgE

C. IgG

D. IgM

back 6

C. IgG

front 7

7. Fcγ receptors (FcγRs) bind to which antibody class?

A. IgA

B. IgG

C. IgE

D. IgM

back 7

B. IgG

front 8

8. Which Fc receptor is primarily expressed on granulocytes and triggers degranulation?

A. FcγR

B. FcεR

C. FcαR

D. FcμR

back 8

B. FcεR

front 9

9. Which Fc receptor is involved in the regulation of cell activation and binds to IgM?

A. FcγR

B. FcμR

C. FcαR

D. FcεR

back 9

B. FcμR

front 10

10. Which Fc receptor is inhibitory and helps turn off antibody secretion by B cells?

A. FcγRI

B. FcγRIIb (CD32)

C. FcεRI

D. FcαR

back 10

B. FcγRIIb (CD32)

front 11

11. Which therapeutic antibody targets CD20 and is used for B-cell non-Hodgkin’s lymphoma?

A. Adalimumab

B. Rituximab

C. Ipilimumab

D. Infliximab

back 11

B. Rituximab

front 12

12. Adalimumab is a fully human antibody that targets:

A. CTLA-4

B. CD20

C. TNF

D. IL-2

back 12

C. TNF

front 13

13. Which therapeutic antibody targets CTLA-4 to treat metastatic melanoma?

A. Rituximab

B. Ipilimumab

C. Adalimumab

D. Nivolumab

back 13

B. Ipilimumab

front 14

14. Which phase of the CD8+ cytotoxic T cell response occurs in secondary lymphoid tissue?

A. Recognition

B. Apoptosis

C. Activation and differentiation

D. Perforin release

back 14

C. Activation and differentiation

front 15

15. What type of cell is known as a “killer cell” that eliminates infected or abnormal host cells?

A. B cell

B. NK cell

C. Helper T cell

D. Plasma cell

back 15

B. NK cell

front 16

16. IgA can fix complement and induce inflammation.

back 16

false

front 17

17. IgM has low affinity but high avidity due to its pentameric structure.

back 17

true

front 18

18. FcεR receptors are found on mast cells and basophils.

back 18

true

front 19

19. CD40/CD40L interaction is essential for dendritic cell licensing.

back 19

true

front 20

20. CTLs can induce apoptosis through Fas/FasL interaction and granzyme release.

back 20

true

front 21

21. Which of the following lists SIX major antibody effector functions?

A. Neutralization, Agglutination, Apoptosis, ADCC, Transcytosis, Complement Activation
B. Neutralization, ADCC, Agglutination, Opsonization, Degranulation, Complement Activation
C. ADCC, Transcytosis, Opsonization, Neutralization, Clonal Selection, Complement Activation
D. Neutralization, Chemotaxis, Opsonization, ADCC, Transcytosis, Apoptosis

back 21

B. Neutralization, ADCC, Agglutination, Opsonization, Degranulation, Complement Activation

front 22

22. Which pairing correctly matches an antibody class with one of its functions or characteristics?

A. IgA – activates classical complement pathway
B. IgE – found mainly in blood as a dimer
C. IgA – mucosal immunity; dimeric; does NOT activate complement
D. IgE – neutralizes pathogens in mucosal secretions

back 22

C. IgA – mucosal immunity; dimeric; does NOT activate complement

front 23

23. What is the general purpose of Fc receptors?

A. To enhance antigen presentation by binding MHC molecules
B. To bind Fc regions of antibodies and trigger effector functions
C. To degrade circulating antibodies
D. To activate B cells independently of antigen

back 23

B. To bind Fc regions of antibodies and trigger effector functions

front 24

24. What is the role of FcγRIIb (CD32) in immune regulation?

A. It enhances B-cell activation and promotes antibody secretion
B. It activates NK cells to induce ADCC
C. It serves as an inhibitory receptor that decreases B-cell activation
D. It triggers complement-dependent cytotoxicity

back 24

C. It serves as an inhibitory receptor that decreases B-cell activation

front 25

25. What is the purpose of DC licensing, and which interaction is essential for it?

A. Allows DCs to activate B cells; requires CD28–CD80
B. Allows DCs to activate CD8+ T cells; requires CD40–CD40L
C. Enhances NK cell cytotoxicity; requires Fas–FasL
D. Stimulates macrophage activation; requires IL-4 signaling

back 25

B. Allows DCs to activate CD8+ T cells; requires CD40–CD40L

front 26

26. Which of the following includes the THREE signals needed for CTL activation?

A. TCR–MHC II binding, IL-4 signaling, perforin release
B. TCR–antigen recognition; CD28 costimulation; IL-2 signaling
C. CD4–MHC II binding; CD40–CD40L; IFN-γ signaling
D. Antibody binding; complement activation; IL-12 release

back 26

B. TCR–antigen recognition; CD28 costimulation; IL-2 signaling

front 27

27. Which statement best compares the missing-self model and the balanced-signals model of NK cell activation?

A. Both models require high MHC I expression for NK killing
B. Missing-self says NK cells kill when MHC I is absent; balanced-signals says NK cells weigh activating vs. inhibitory signals
C. Missing-self depends on antibodies; balanced-signals does not
D. Both models state that inhibitory signals dominate when MHC I is missing

back 27

B. Missing-self says NK cells kill when MHC I is absent; balanced-signals says NK cells weigh activating vs. inhibitory signals

front 28

28. Which best describes antibody-dependent cellular cytotoxicity (ADCC) performed by NK cells?

A. NK cells kill pathogens using complement proteins
B. NK cells recognize antigen via TCR and directly induce apoptosis
C. Antibodies coat a target, NK cells bind the Fc region, and induce killing
D. NK cells phagocytose antibody-coated pathogens

back 28

C. Antibodies coat a target, NK cells bind the Fc region, and induce killing