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Pharmacology Chapter 1

front 1

Pharmakon

back 1

Is greek for drugs

front 2

Logos

back 2

is Greek for science

front 3

What is pharmacology

back 3

Deals with the study of drugs and their actions or effects

front 4

What are therapeutic methods to treating illnesses

back 4

diet therapy, drug therapy, Physiotherapy, Psychotherapy,

front 5

biologic therapy

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A new class of drugs has transformed treatment in patients

that attack the body with its own organs tissues and cells

ex cancer medication

front 6

what is a biologic agent

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Are large complex proteins manufactured in a living system

front 7

When a drug name is not capatilize is it the generic version or the brand name.

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It is the generic version

front 8

When a drug name is Capitalized is it The generic version or The Brand name.

back 8

It is the brand name

front 9

Which names of a drug should the nurse use when teaching a patient about a new prescription?

back 9

generic name and trade

front 10

Body systems classification

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Cardiovascular and gastro intestinal

front 11

Therapeutic use

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antacids

antibiotics

front 12

Psychological or chemical reaction

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anticholinergics/ calcium channel blockers

front 13

where can you get resources for drug information

back 13

The united states pharmacopeia/ the Usp dictionary

package inserts, Nursing Journals, electronic data base

front 14

Which source of information is best for the nurse to obtain drug information?

back 14

Nursing journals

front 15

Where can you get sommon sources of drug information

back 15

electronic databases

Lexicomp

ePocrates

DailyMed

front 16

what is the controlled substance act of 1970

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The controlled substance act of 1970 is the classifacations or schedules of controlled substance

front 17

schedule I drug

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high abuse potetial ex heroin

front 18

schedule II

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high abuse potential; some medical use (e.g., pentobarbital).

front 19

Schedule III

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High abuse potential; some medical use (e.g., codeine)

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schedule IV

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Low abuse potential; some medical use (e.g., diazepam).

front 21

schedule v

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low abuse potential ex Robitussin

front 22

Which is responsible for monitoring the drug safety in the united states

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The FDA is responsible for overseeing drug and cosmetic manufacture and promotion to determine their safety before allowing them to be released to the public.

front 23

which drug schedule indicates drugs with highest risk for abuse?

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Schedule I drugs have the highest potential for abuse. They are not currently accepted for medical use in the United States.

front 24

manufactures and prescribes must do what?

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The must be registered with Dea requirements must be met in order to dispense scheduled medications

front 25

What must a person have to have in order to get scheduled drugs ?

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Prescription drugs require an order by a health professional who is licensed to prescribe drugs; nonprescription (over-the-counter [OTC]) drugs are sold without a prescription.

front 26

HOw many years does it take to bring a new drug to the market

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It currently takes an average of 8 to 15 years and more than $2 billion in research and development costs to bring a single new drug to market.

front 27

What is fast tracking

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Used to expedite drug development and approval for life-threatening illnesses

front 28

Parallel tracking

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Used for patients with life-threatening illnesses who cannot participate in controlled trials, when there is no other alternative

front 29

What is postmarking survelance stage

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ongoing review of effects of new drugs

front 30

What is black box warning

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Indicates a very serious life-threatening problem

Probability of a drug acquiring a new black box warning or being withdrawn from the market within 25 years of being released is 20%

front 31

orphan drug what are they ?

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They are created for rare conditions ex sickle cell anemia

front 32

Specific sites where drugs form chemical bonds

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Drug receptors

front 33

Study of interactions between drugs and their receptors and the series of events that result in a pharmacologic response

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Pharmacodynamics

front 34

Agonists

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Drugs that interact with a receptor to stimulate a response

front 35

Drugs that attach to a receptor but do not stimulate a response

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Antagonist

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Partial agonists

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Drugs that interact with a receptor to stimulate a response but inhibit

front 37

Enteral

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Via the gastrointestinal tract by the oral, rectal, or nasogastric routes

front 38

Parenteral

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Bypasses the GI tract by using subcutaneous, intramuscular, and intravenous injection

front 39

Percutaneous

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Absorbed through the skin and mucous membranes

Inhalation, sublingual, or topical

front 40

ladme

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Liberation: Drug released from dosage form

Absorption: Depends on route of administration

Distribution: Depends on circulation to be transported throughout body

Metabolism: Depends on enzyme systems

Excretion: Depends on GI tract and kidneys

front 41

A drug which cannot pass through the blood-brain barrier would not be effective in treating meningitis, a brain infection. A drug which CAN pass through the placental barrier could affect the fetus.

back 41

no data

front 42

liberation

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Drug released from dosage form and is dissolved in body fluid

front 43

Idiosyncratic reactions

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Occur when something unusual/abnormal happens when drug is first administered

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Allergic reactions

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Occur among patients who have previously been exposed to a drug and whose immune systems have developed antibodies to the drug

front 45

Drug Interactions

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Said to occur when the action of one drug is altered or changed by the action of another drug

front 46

Changes in Absorption

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Most drug interactions that alter absorption take place in the GI tract

Antacids increase the gastric pH and can inhibit the dissolution of ketoconazole tablets

front 47

Changes in Distribution

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If a drug is 90% bound to a protein, then 10% of the drug is providing the physiologic effect.

front 48

Changes in Metabolism

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Drug interactions usually result from a change in metabolism that involves inhibiting or inducing the enzymes that metabolize a drug

front 49

Common drugs that bind to enzymes and increase the metabolism of other drugs are

back 49

phenobarbital, carbamazepine, rifampin, and phenytoin.

front 50

Changes in Excretion

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Drug interactions that cause a change in excretion usually act in the kidney tubules by changing the pH to enhance or inhibit excretion

front 51

A patient reports postoperative pain, and the nurse administers IV morphine (a narcotic analgesic) to ease the pain. Fifteen minutes later, the nurse notes that the patient is very drowsy, respirations are slow and shallow, and oxygen saturation is low. The nurse administers another drug that decreases the morphine’s action. What is this effect called?

back 51

Antagonistic