Somatic vs. Autonomic:
(motor pathway, ganglia, afferent input)
Somatic:
- single neuron from CNS to effector
- No ganglia involved
- Afferent origin from skeletal muscles, joints, and skin
Autonomic:
- Two-neuron chain: preganglionic and postganglionic
- Uses ganglia (clusters of neuron cell bodies in the PNS)
- Afferent input from visceral organs (digestive, cardiovascular)
Thoracolumbar (Origin/Function)
Sympathetic Division
- Origin: Preganglionic neurons in the lateral horns of spinal cord segments
- Function: Activated during exertion, stress, or emergency; prepares the body for intense physical activity
Craniosacral (Origin/Function)
Parasympathetic Division
- Origin: Preganglionic neurons in the brainstream
- Function: Active during relaxed states. Promotes digestion, energy conservation, and bodily maitenance
Thoracolumbar (Sympathetic) Ganglia
Sympathetic Chain Ganglia
Collateral Ganglia
Adrenal Medulla
Sympathetic Chain Ganglia
Paired and located near the spinal cord. They send messages to effectors in the thoracic cavity, head, body wall, and limbs
Collateral Ganglia
Unpaired and located anterior to the spinal column. They run to organs in the abdominal cavity and innervate visceral effectors in the abdominal pelvic cavity
Adrenal Medulla
Found on the kidney; instead of a direct nerve link, the adrenal medulla releases epinephrine and norepinephrine directly into the bloodstream
- These circulating hormones are distributed throughout the body to target organs
Thoracolumbar (Sympathetic) Neurotransmitters
- Preganglionic neurons release Acetylcholine (ACh) which excites the chain ganglia
- Most postganglionic neurons release Norepinephrine (NE), which is usually excitatory but depends on the receptor at the target organ
Thoracolumbar (Sympathetic) Effects on Target Organs
Eye:
Salivary Glands:
Cardiovascular and Respiratory Systems
Digestive Organs
Kidney and Bladder
Reproductive Organs
Eye: Causes a dilation of the pupils
Salivary Glands: Mostly not excited; stimulation is more associated with parasympathetic activation
Cardiovascular and Respiratory Systems: Increases heart rate and respiration
Digestive Organs: Not excited or stimulated (resources are diverted away during "fight or flight"
Kidney and Bladder: Activity is dampened. The detrusor muscle of the bladder is relaxed, while the sphincter is contracted to prevent the release of urine
Reproductive Organs: Not in an excitatory mode
Craniosacral (Parasympathetic) Ganglia
- The preganglionic neurons are located in the brain stem (with cranial nerves) and the sacral spinal cord. The preganglionic fibers are long because the ganglia are not adjacent to the spinal cord
- The ganglia (peripheral ganglia) are located within or right adjacent to the target organs
- The preganglionic neurons release acetylcholine (ACh), which is excitatory to the ganglia
- The postganglionic neurons also release ACH, which will usually be inhibitory, but depends on the receptor
Cranial Nerve Outflow
Oculomotor:
Facial:
Glossopharyngeal:
Vagus:
Sacral Outflow:
Oculomotor: Innervates the levator palpebrae (lifts the eyelid)
Facial: Controls tear glands and salivary glands
Glossopharyngeal: Important for salivary gland innervation
Vagus: Responsible for about 75% of all parasympathetic outflow, much of it related to digestive function
Sacral Outflow: The preganglionic fibers form the pelvic nerves, which innervate pelvic organs
Craniosacral (Parasympathetic) Effects on Target Organs
Eyes:
Digestive System:
Defecation:
Urination:
Cardiovascular:
Respiratory:
Reproductive:
Eyes: Constriction of the pupils and a "drowsy" eyelid
Digestive System: Secretion of digestive glands, secretion of hormones promoting nutrient absorption, and increased smooth muscle activity along the digestive tract to move matter
Defecation: stimulation and coordination of defecation
Urination: contraction of the urinary bladder (the detrusor muscle) and relaxation of the urinary sphincter
Cardiovascular: reduction in heart rate and force of contraction
Respiratory: Constriction of the respiratory passageways
Reproductive: Sexual arousal
Dual Innervation
Innervated by both the sympathetic and parasympathetic systems (most vital organs)
- The two systems have opposite effects but work together to maintain homeostasis
How does the ANS maintain Homeostasis?
Through various reflexes
Layers protecting the brain (superficial to deep
Scalp
Epicranialaponeurosis: a broad, tendon-like sheath of dense connective tissue
Loose connective tissue
Periosteum: the outer fibrous layer covering the cranial bones
Cranium: bony skull
Meninges: three protective membrane layers
- Dura mater --> arachnoid mater ---(subarachnoid space containing CSF)---> pia mater
Major Regions of the Brain
Cerebrum, Cerebellum, Diencephalon, Midbrain, Pons, medulla Oblongata
Cerebrum
Largest part of the brain, responsible for higher functions.
- Hemispheres, longitudinal fissure, contralateral control, corpus callosum, cerebral cortex
Contralateral Control
Each cerebral hemisphere controls the opposite (contralateral) side of the body.
Longitudinal Fissure
Separates the left and right cerebral hemispheres
Corpus Callosum
A large bundle of white matter fibers deep within the longitudinal fissure that allows communication between the two hemispheres
Cerebral Cortex
The outer layer of the cerebrum, composed of gray matter (contains neuronal cell bodies)
- gyri = folds
- sulci = grooves
Frontal Lobe
Primary Motor Cortex (Precentral Gyrus), Premotor Cortex, Prefrontal Cortex
Primary Motor Cortex (Precentral Gyrus)
Initiates voluntary skeletal muscle movement
Premotor cortex
Plans and coordinates complex movements
Prefrontal cortex
Responsible for executive functions, decision-making, and personality
Parietal lobe
Primary Somatosensory Cortex (Postcentral Gyrus), Somatosensory Association Area
Primary Somatosensory Cortex (Postcentral Gyrus)
Receives and processes sensory information from the body
Somatosensory Association Area
Integrates and interprets sensory information
Occipital Lobe
Visual Cortex, Visual Association Area
Visual Cortex
Processes visual information received from the eyes
Visual Association Area
Interprets visual stimuli
Temporal Lobe
Auditory cortex, olfactory cortex, Gustatory cortex
Association fibers
Bundles of white matter that allow different regions within the same cerebral hemisphere to communicate
Cerebellum
Inferior to the occipital lobe; integrates sensory input from proprioceptors, the visual system, and the auditory system to fine-tune motor commands
Diencephalon
Connects the brain stem to the cerebrum. Divided into:
1. Epithalamus
2. Thalamus
3. Hypothalamus
Epithalamus
Contains the pineal gland: an endocrine gland that secretes melatonin
Thalamus
Acts as the main relay station for sensory information. Nearly all input passes through the thalamus before being directed to the appropriate area of the cerebral cortex
Hypothalamus
Master control center for the autonomic nervous system and the endocrine (hormone system); regulates the release of hormones from the pituitary gland
The brain stem
Midbrain (Mesencephalon), Pons, Medulla Oblongata
Mesencephalon (Midbrain)
Processes visual and auditory data and generates reflexive somatic motor responses; plays a key role in maintaining consciousness
Pons
Acts as a relay center, passing sensory information to the cerebellum and thalamus; point of origin for several cranial nerves
Medulla Oblongata
Contains autonomic centers that regulate functions; relay station for information traveling to the thalamus. Connects directly to the brain stem
Basal Ganglia
Subcortical structures involved in the control of voluntary motor movements, procedural learning, and posture
- substantia nigra: produces dopamine
Limbic System
Strongly tied to the sense of smell and emotional states. Includes the hippocampus (memory formation), amygdala (emotion and memory), and parts of the thalamus and hypothalamus
Ventricles
fluid-filled cavities in the brain
-lateral ventricles, third ventricle, fourth ventricle
Lateral Ventricles (2)
The largest, one per each cerebral hemisphere
Third Ventricle
Narrow Cavity in the diencephalon
Fourth Ventricle
Located between the brain stem and the cerebellum
Choroid plexus
Network of specialized ependymal cells that line the ventricles and produce cerebrospinal fluid
CSF Flow
Lateral ventricles ---(interventricular foramen)---> third ventricle----(cerebral aqueduct)---> fourth ventricle ----(foramina in the roof of the fourth ventricle)---> subarachnoid space
Olfactory Cranial Nerve
Sensory; sense of smell
Optic
Sensory; Vision
Oculomotor
Motor: controls 4 of the 6 extracurricular eye muscles and the levator palpebrae superioris (elevates eyelid)
Trochlear
Motor; Controls the superior oblique eye muscle (moves eye down and out)
Trigeminal
Sensory: Sensation from the face
Motor: Muscles of mastication
Abducens
Motor: controls the lateral rectus eye muscle (abducts the eye, moves it laterally)
Facial
Sensory: taste from the anterior 2/3 of the tongue
Motor: Muscles of facial expression
Vestibulochlear
Sensory: hearing and balance/equilibrium
Glossopharyngeal
Sensory: taste from the posterior 1/3 of the tongue; monitors blood pressure in the carotid artery
Motor: Assists in swallowing
Vagus
The longest cranial nerve/primary nerve of the parasympathetic nervous system
- Innervates visceral organs in the thorax and abdomen also important for speech and swallowing
Accessory
Motor; innervates the sternocleidomastoid and trapezius muscles (neck and shoulders)
Hypoglossal
Motor; innervates the intrinsic and extrinsic muscles of the tongue, controlling tongue movement for speech and swallowing