Excitability
the ability to respond to stimulus
Conductivity
electrical changes that travels along the plasma membrane opening voltage-gated channels
Contractility
contractile proteins within in the muscle slide past one another (sliding
filament)
Elasticity
ability to return to its original length
Extensibility
Lengthening of a muscle fiber
skeletal Muscle Functions
-Body Movement
-Maintenance of posture
-Protection and
Support
-Regulating elimination
of materials (sphincters at
orifices)
-Heat Production
Muscle Fiber
muscle cell
Fascicle
group of
bound muscle fibers
Myofibril
small tubules with in the muscle fiber that contain the contractile
unit called
sarcomere
Connective Tissue Functions
-Protection
-Sites for distribution of blood vessels and nerves
-Attachment to the skeleton
3 Layers of Connective Tissue
-Epimysium
-Perimysium
-Endomysium
Epimysium
-Surrounds the whole muscle
-Dense irregular tissue
Perimysium
-Surrounds the fascicle
-Dense irregular tissue
-Contains lots of blood vessels and nerves
Endomysium
-Surrounds and electrically insulates each individual muscle fiber
-Areolar tissue
-Contains reticular fibers to help bind together muscle fibers
Tendon
-Thick cord like structure
-Formed by three layers of connective tissue
-Dense irregular tissue
-Attach muscle to bone
Aponeurosis
-A thin flattened sheet of dense irregular tissue
-Connects two muscle bellies
Muscle Fiber Structure
-Multi nucleated
-Special cell membrane
-Sarcoplasmic reticulum
-Myofibrils
-Myofilaments
-Sarcomere
Multinucleated
Myoblasts fuse to form a single muscle fiber
Satellite Cells
Myoblasts that do not fuse
-Remain in muscle tissue to repair damaged muscle tissue
Sarcolemma
Conducts electrical impulses
T-tubules
deep invaginations of the sarcolemma that extend into the skeletal muscle fiber to stimulate the sarcoplasmic reticulum
Sarcoplasmic Reticulum (SER)
Internal membrane complex that is similar to smooth ER
Terminal Cisternae
Sacs at the end of the SER that store calcium
Calcium pumps vs calcium channels
Pumps: Move calcium into SER
Channel: Move calcium out of SER
Calcmodulin and Calsquestrin
Proteins that bind calcium with the SER
Myofibrils
-Long, cylindrical structures that extend the length of the muscle fiber
-80% of the skeletal muscle volume
-Composed of the myofilaments
Myofilaments
-Contractile proteins that are bundled within the myofibrils
2 Types of Myofilaments
Myosin=thick
Actin=thin
Thick
-200 to 500 myosin proteins
-Myosin: globular head and elongated tail (golf club)
Thin
-Composed of 2 strands of actin protein
-Actin: 2 protein strands that are twisted around each other
Tropomyosin
regulatory protein that covers the myosin binding sites of actin until
Troponin
regulatory protein that binds with calcium to move tropomyosin off of the myosin binding sites of actin
Sarcomere
-Repeating units within the myofilaments
-The contractile unit
Z Disc
proteins that are positioned perpendicular to the myofilaments and serve as anchors for the thin filaments
-separates sarcomeres
I Bands
extend in both directions of a Z disc
-thin filaments only
-disappears during maximal contraction
A Band
central region that contains the entire
thick filament
-thin overlaps thick slightly
-does not change shape during contraction
H Zone
most central portion of the A band
-NO thin filament over lapping! Thick filaments only!
-disappears as well
M Line
thin transverse protein meshwork in the center of the H zone
-attachment for thick filaments
Connection (green coil on diagram)
extends from the Z disc to the M line through the core of each thick filament
-stabilizes thick filaments
-has coiled section to help with recoil; able to return to normal shape after contraction
Dystrophin
a complex protein that anchors myofibrils to other proteins with in
the
sarcolemma that extend to the endomysium
GO OVER MUSCLE CONTRACTION STEPS!!!
Find them in slides on #33 and after that.
Skeletal Muscle Fiber Types
-Fast-twitch
-Slow-twitch
-Fast Glycolytic
Fast-twitch
-Anaerobic
-Larger in diameter
-Strength and speed
-Light in color
-Contains medium amounts of mitochondria and myoglbin
Slow-twitch
-Aerobic
-Small in diameter
-appear red
-contain lots of mitochondria and myoglobin
-endurance
Fast Glycolytic (anaerobic fibers)
-anaerobic
-largest fibers
-white in color
-contains few mitochondria or myoglobin
-short duration (sprinting and weight lifting)
Factors affecting tension
-length-tension relationship
-length-tension curve
Length-tension relationship
the amount of overlap of thick and thin filaments when the muscle begins its contraction
length-tension curve
muscle generates different amounts of tension dependent upon its length at the time of stimulation
Muscle Tension
resting tension in a muscle generated by involuntary nervous stimulation of the muscle
Muscle Fatigue
The reduced ability to inability of the muscle to produce muscle tension
Isometric contraction
contraction of a muscle where no movement is created
Isotonic contraction
muscle tension results in movement of the muscle
Concentric contraction
shortening of the muscle length
(Occurs when the muscle tension is greater than resistance)
Eccentric contraction
lengthening of the muscle
(Muscle exerts less force than needed to move the load)
Cardiac Muscle Cells
-Short
-Y branching
-1 or 2 nuclei
-striated
-joined by intercalated disc
Autorhythmic
Specialized muscle cells that are
responsible for repetitious, rhythmic
contractions
Compare smooth vs skeletal muscle
SMOOTH
-Thick filaments have myosin heads along entire length
-Myosin heads have a modification to latch-on to thin filament (latchbridging)
-NO troponin, instead has MLCK (myosin light-chain kinase) and myosin light chain phophatase
Compare smooth vs skeletal muscle
SKELETAL
-Thick filaments have myosin heads along the ends
-No latchbridging
-Has troponin
Compare smooth vs skeletal muscle
BOTH
-Calcium stimulates contraction
-Myosin uses ATP for power stroke
-Thin filament slides
past the thick filament