Chapter 19 (Hepatitis & Liver Disease) Flashcards

Which of the following natural products is used for liver disease?

Which of the following is a formulation of tenofovir?

Which medication has a warning for serious symptomatic bradycardia if used in combination with amiodarone?

Which of the following drugs is correctly matched with the hepatitis virus that it treats?

A patient complains of abdominal pain, nausea, itching, dark urine and yellow eyes/skin. Which of the following tests can help evaluate the underlying cause?

Which of the following is used to assess the severity of liver disease?

SH is beginning therapy with Pegasys (pegylated interferon-alfa-2a). The pharmacist will counsel him on possible side effects from Pegasys therapy. He should receive counseling on which of the following side effects? (Select ALL that apply.)

The pharmacist is counseling a patient who is starting HCV treatment with Mavyret. Which of the following would be an appropriate counseling point?

JH has cirrhosis and comes to the pharmacy to ask about pain medication for his headache. Which of the following should be avoided due to the risk of decompensation?

Which of the following is the first-line treatment for spontaneous bacterial peritonitis?

Which patients are at risk of contracting hepatitis B? (Select ALL that apply.)

SC, a 33-year-old female, hands the pharmacist a prescription for ribavirin. She states this is a new prescription for her hepatitis C infection. She is not currently taking any other medications for hepatitis C. The following information is available from the clinic records:

Weight: 145 poundsAlbumin (g/dL) = 4.2 (3.5–5)Potassium (mEq/L) = 5.1 (3.5–5)BUN (mg/dL) = 23 (7–20)SCr (mg/dL) = 1.3 (0.7–1.3)AST (IU/L) = 83 (10–40)ALT (IU/L) = 75 (10–40)Bilirubin (mg/dL) = 0.7 (0.1–1.2)INR = 1.1
Question:The pharmacist should not fill the prescription. What should the pharmacist discuss with the prescriber?

Which of the following drug classes is used to treat ascites due to portal hypertension?

Which of the following antiviral medications would be expected to have a drug-drug interaction with pantoprazole? (Select ALL that apply.)

In a patient unable to tolerate lactulose for the prevention of hepatic encephalopathy, which of the following would be the best recommendation?

History of Present Illness:HF is a 31-year-old Caucasian male transferred to the hospital from a nearby jail with poorly healing cellulitis on his left lower extremity that has not responded to treatment.
Labs:
WBC (cells/mm³) = 13.6 (4 – 11 x 10³)
Hgb (g/dL) = 15 (male: 13.5 – 18, female: 12 – 16)
Hct (%) = 44.2 (male: 38 – 50, female: 36 – 46)
Plt (cells/mm³) = 182 (150 – 450 x 10³)
AST (IU/L) = 37 (10 – 40)
ALT (IU/L) = 32 (10 – 40)
Albumin (g/dL) = 4.1 (3.5 – 5)
Anti-HCV = positive
HCV RNA PCR = positive
Wound Culture:
Many WBC, moderate RBC, many Gram-positive cocci resembling S. aureus.

Liver Biopsy:
Changes consistent with chronic HCV infection. No cirrhosis.

Plan:
Discontinue Keflex and consult infectious disease pharmacist for an oral antibiotic to cover community-acquired MRSA.

**case above**

Which of the following tests must be performed prior to starting treatment for hepatitis C?

Which of the following should be recommended for SB's abdominal distention?

Which of SB's medications is correctly matched with its indication?

What is the most likely explanation for SB's INR result?

Which medication is most likely contributing to SB's complaint of diarrhea?

What is the primary reason SB takes nadolol?

Which of the following medications have a boxed warning for liver damage? (Select ALL that apply.)

A pharmacist receives an Epivir prescription for a 32-year-old female whose past medical history includes iron deficiency anemia, hypothyroidism and hepatitis B. The pharmacist should contact the prescriber to discuss which of the following?

Which of YB's lab abnormalities indicate chronic liver disease and reduced synthetic function of the liver?

Several days later, YB's variceal bleed has been controlled. Her renal function is much improved, and her other labs are stable. She is noted to have ascites. In addition to sodium restriction, which of the following is an appropriate recommendation for treating her ascites?

The pharmacist received a new order for "Lactulose 30 mL PO Q6H. Titrate to 2-4 soft bowel movements per day." Which of the following best describes the expected effect on YB's labs?

Several days later, YB's acute variceal bleed has been controlled. Her renal function is much improved, and her other labs are stable. Her BP is 145/83, and HR is 83. Which of the following recommendations would reduce her risk of having another variceal bleed?

Which of the following is used to prevent and treat Wernicke-Korsakoff syndrome?

Which of the following is correct regarding the treatment of HCV?

DW has a history of alcohol abuse and cirrhosis secondary to alcohol. Which of the following could be considered to prevent alcohol relapse? (Select ALL that apply.)

What is the mechanism of action for lactulose in treating hepatic encephalopathy?

Which of the following is correct regarding the need to test for HIV before starting HBV therapy? (Select ALL that apply.)

Interferons are known to cause or aggravate which of the following? (Select ALL that apply.)

DL's physician plans to begin treatment for hepatitis. Which medication/s should be avoided in combination with DL's acid-suppressive therapy? (Select ALL that apply.)