Rocuronium (Zemuron)
Class
Neuromuscular blocker (non-depolarizing)
Mechanism of action
Complete muscular relaxation by binding to the receptor for acetylcholine at the neuromuscular junction, without initiating depolarization of the muscle membrane. As the concentration of acetylcholine rises in the neuromuscular junction, Pancuronium is displaced and muscle tone is regained.
Succinylcholine (Anectine)
Class
Neuromuscular blocker, skeletal muscle relaxant.
Mechanism of Action
Ultra short acting depolarizing skeletal relaxant that mimics acetylcholine as it binds with the cholinergic receptors on the motor end plate, producing a phase I block as manifested by fasciculations.
Vecuronium (Norcuron)
Class
Nondepolarizing neuromuscular blocker
Mechanism of Action
Intermediate-acting, non-depolarizing, neuromuscular blocking agent. Non-depolarizing agents produce skeletal muscle paralysis by blockade at the myoneural junction. Unlike depolarizing agents, [Rx] has little agonist activity, with no depolarizing effect at the motor endplate.
Ketamine (Ketalar)
Class
Sedative, analgesic dissociative anesthetic
Mechanism of Action
Blocks pain receptors and minimizes spinal cord activity, affecting the association pathways of the brain between the thalamus and the limbic system.