Adenosine
Special Considerations:
- Short half-life limits side effects in most patients.
- Pregnancy Safety: Category C.
Amiodarone (Cordarone)
Special Considerations:
- Administer cautiously in patients with Heart Failure or poor systolic function.
- Pregnancy Safety: Category C
Aspirin (ASA)
Special Considerations:
- Not recommended in pediatric population.
- Pregnancy Safety: Category D.
Atropine sulfate
Special Considerations:
- Moderate doses dilate pupils.
- Pregnancy Safety: Category C.
Calcium chloride
Special Considerations:
- For pediatrics: if calcium gluconate is unavailable, 1-2 ml of 10% calcium chloride solution, diluted with IV fluid, may be substituted.
- Pregnancy Safety: Category C.
Diltiazem (Cardizem)
Special Considerations:
- Use in caution in patients with renal or hepatic dysfunction.
- Pregnancy Safety: Category C.
Dopamine (Intropin)
Special Considerations:
Effects are dose-dependent;
- Dopaminergic response: 2 - 4mcg/kg/min: dilates vessels in kidneys; increased urine output.
- Beta-adrenergic response: 4 - 10mcg/kg/min: Increased chronotropy and inotropy.
- Adrenergic response: 10 - 20mcg/kg/min: Primarily alpha stimulant/vasoconstriction.
- >20mcg/kg/min: reversal of renal effects/override alpha effects.
- Always monitor drip rate.
- Avoid extravagation injury.
- Pregnancy Safety: not established.
Epinephrine
Special Considerations:
- Pregnancy Safety: Category C.
Fentanyl citrate (Sublimaze)
Special Considerations:
- Pregnancy Safety: Category C.
Furosemide (Lasix)
Special Considerations:
- Ototoxicity and deafness can occur.
- Pregnancy Safety: Category C.
Lidocaine (Xylocaine)
Special Considerations:
- Reduce maintenance infusions by 50% if patient is over 70 years of age, has liver disease, or is in CHF or shock.
- A 75-100 mg bolus maintains levels for only 20 minutes.
- If bradycardia occurs with PVCs, always treat the bradycardia with atropine.
- Exceedingly high doses can result in coma or death.
- Pregnancy Safety: Category B.
Magnesium sulfate
Special Considerations:
- IV calcium gluconate or calcium chloride should be available as antagonist if needed.
- Use with caution in patients with renal failure.
- Being used for acute MI patients in some systems under Medical Direction.
- Pregnancy Safety: Recommended that drug not be given in the 2 hours before delivery, if possible.
Metoprolol (Lopressor/Toprol XL)
Special Considerations:
- Not recommended in pediatric population. The safety and effectiveness have not been established in children.
- Pregnancy Safety: Category C (manufacturer); D (2nd and 3rd trimesters - expert analysis).
Morphine sulfate
Special Considerations:
- Safety in neonate not established.
- Use with caution in geriatric population and those with COPD, asthma.
- Naloxone should be readily available as antidote.
-
Pregnancy Safety: Category C.
**Rapidly crosses the placenta.
Nitroglycerin (Nitrolingual/NitroQuick/Nitro-Dur)
Special Considerations:
- Hypotension more common in geriatric population.
- Decomposes if exposed to light or heat.
- Must be kept in airtight containers.
- Active ingredient may have a stinging effect when administered SL.
- Pregnancy Safety: Category C.
Norepinephrine
Special Considerations:
- Infuse through a large, stable vein to avoid extravasation and tissue necrosis.
- Drug or poison induced hypotension may require higher doses to achieve adequate perfusion.
-
Pregnancy Safety: Category C.
**Use cautiously during pregnancy and while breastfeeding. May cause fetal anoxia when used in pregnancy.
Oxygen
Special Considerations:
- Be familiar with liter flow and each type of delivery device used.
- Supports possibility of combustion.
Sodium Bicarbonate
Special Considerations:
- Must ventilate patient after
administration.
Intracellular acidosis may be worsened by production of carbon dioxide. - May worsen CHF.
- Pregnancy Safety: Category C.