T cell CTLA interaction with APC B7 activates T cells?
False - inactivates
T cell PD-1 activation by PD-L1 inactivates T cells by blocking CD28/TCR-dependent signaling?
True
Cold tumors are not likely to trigger a strong immune response due to the exclusion of T cells in the microenvironment?
True
Checkpoint inhibitors would be especially useful in what type of tumor?
Cold
Which mAb targets CTLA-4 to block T cell-tumor interaction?
Ipilimumab
Which mAb targets PD1?
Nivolumab, Pembrolizumab
ADE of Nivolumab:
dyspnea, musculoskeletal pain
ADE of Pembrolizumab:
arthralgia, diarrhea, pruritis
Which mAb targets PD1?
Atezolizumab, Durvalumab
Hypo/hyper-thyroidism,
adrenal insufficiency,
pancreatitis, T1DM, myasthenia gravis, Gullain-Barré Syndrome,
ocular inflammation and p
otential toxicity to embryo or fetus are side effects of which agents:
Atezolizumab, Durvalumab
Capillary leak syndrome is associated with what agent?
Aldesleukin
Which agent is a recombinant IL-2 that induces T-cell and NK cell proliferation?
Aldesleukin
Patients should have normal renal and hepatic function; close
supervision
in an ICU-capable facility is recommended for what
agent?
Aldesleukin
What is the target of Interferon Alfa 2B?
IFNAR2 - activates JAK/STAT in T cells
Myelosuppression is associated with which agent?
Interferon Alfa-2B
Lenalidomide increases the production of what?
IL-2
IFNy
Sipuleucel-T reprograms a patient's PBMCs by exposure to:
PSA
PAP
Which vaccine increases a patient's GM-CSF?
T-VEC
Talimogene Laherparepvec
Which agents are used for CAR-T therapy?
Tisagenlecleucel, Axicabtagene Ciloleucel
MOA of CAR-T therapy?
T cell transfer to make a patient OVER-EXPRESS
CD28
TCR
that interacts with
CD19
CAR-T induced cytokine release is associated with what agent?
IL-6
What two agents can be used to treat CRS?
siltuximab and tocilizumab
Which two agents are anti-CD20 antibodies?
Rituximab, Obinutuzumab
Infusion reactions can be lethal with what agents?
Anti-CD20 agents (Rituximab, Obinutuzumab)
Which CD-20 agent has the lowest risk of infusion reactions?
Rituximab
Which two agents are radioisotope-conjugated anti-CD20 antibodies?
- Tositumomab: 131 Iodine
- Ibritumomab: 90 Yttrium
Which agent is an anti-CD19 antibody?
Blinatumomab
What is the BBW of Blinatumomab?
1. CRS
2. Neurotoxicity
Which agent is an anti-CD22 antibody?
Inotuzumab
What is the BBW of Inotuzumab?
Hepatotoxicity
QT prolongation
Which agent is an anti-CD33 antibody?
Gemtuzumab
Myelosuppression occurs in 100% of patients with which therapy?
Gemtuzumab
BBW of Gemtuzumab
Hepatotoxicity
Veno-occlusive disease
Which agent is an anti CD52 antibody?
Alemtuzumab:
Which agent can worsen thyroid gland disorders?
Alemtuzumab:
BBW of Alemtuzumab:
Potentially lethal infusion reactions
Autoimmune reactions
Which agent is an anti CXCR4 antibody?
Plerixafor
Which agent is an anti CD30 antibody?
Brentuximab vedotin
Brentuximab vedotin is conjugated to what
MMAE
Which mutations affect a protein whose activity is sufficient and necessary to cause neoplastic growth?
Driver mutations
What is primary driver of pancreatic cancer?
KRAS
Will Gefitinib work on KRAS?
No
-RAS signaling pathway no longer needed input to signal and does not respond to receptor blockade
What tumor suppressors are associated with hereditary breast and ovarian cancer?
BRCA1/BRCA2
What agent can be used for CML when imatinib no longer works due to clones that prevent binding?
Ponatinib