METABOLISM
ALL chemical reactions in body
CATABOLISM
Chemical reactions: BREAK DOWN complex organic molecules
ANABOLISM
Chemical reactions: COMBINE simple molecules to FORM complex molecules
GLYCOGENSIS
Formation of glycogen to store glucose
Glucose -> Glycogen
GLYCOGENOLYSIS
Pathway of which glycogen break down to glucose
Glycogen
-> Glucose (if blood glucose is down)
GLUCONEOGENSIS
Formation of sugar from non sugars (fats and protein)
NUTRIENT
A substance in food the body uses to promote normal growth, maintenance and repair
ESSENTIAL NUTRIENTS
- Cannot be made by the body in sufficient quantities to meet the
body's needs
must be obtained by diet.
6 MAJOR NUTRIENT CATEGORIES
- carbohydrates
- proteins
- fats
- vitamins
- minerals
- water
NUTRITIONALLY COMPLETE PROTEINS
- Can find in: eggs, milk, fish and most meats
- Meet all the body's amino acid requirements for tissue maintenance and growth
INCOMPLETE PROTEINS
- Nutritionally incomplete
- Low in one or more of the essential amino acids
FAT SOLUBLE VITAMINS
- Bind to ingested lipids and are absorbed with their digestion products (through lymph)
- Stay in the body much longer than water-soluble vitamins
- Too many fat-soluble vitamins can be toxic
WATER SOLUBLE VITAMINS
- Absorbed along with water through the GI tract
- Usually excreted usually within 1 hour
FAT SOLUBLE VITAMINS EXAMPLES
- Vita A, D, E & K
WATER SOLUBLE VITAMINS EXAMPLES
- B-complex vitamins
- Vitamin C
VITAMIN B
- Acts as coenzyme
- Deficiencies: beriberi, anemia, pellagra
VITAMIN C
- Maintains connective tissues
Deficiency: scurvy, bleeding gums
VITAMIN A
- Good for eyes and skin
Deficiency: night-blindness OR permanent blindness
VITAMIN D
- Bone growth & absorption of Calcium
Deficiency: rickets in children
VITAMIN E
- Antioxidant
VITAMIN K
- Blood clotting
Deficiency: severe bleeding
CALCIUM (Ca)
- bone growth
- muscle contraction
- blood clotting
PHOSPHORUS (P)
- bone growth
- tooth formation
- APT & nucleic formation
IRON (Fe)
- Hemoglobin synthesis: transport oxygen from lungs to tissues
IODINE (I)
- Formation of thyroid hormones
SODIUM (Na) & POTASSIUM (K)
- Acid base balance
- Water balance
CARBS
- Mostly plants
- Energy source and fibers
LIPIDS
- Animal products: meats and dairy
- Absorb fat soluble vitamins
- Cholesterol used in bile salt & steroid hormone
VITAMINS
- Found in all major food group
- Coenzymes to help enzymes do their job
HOW AMINO ACID ARE METABOLIZED ENERGY
- Amino acids to be used for energy, they must be deaminated (their amine group NH2) must be removed
- Leftover of amino acid is converted to pyruvic acid
- Enter the Krebs cycle
IMPORTANT EVENTS AND PRODUCTS OF GLYCOSIS
- Glucose reacts with ATP
- ATP gives off energy; change to ADP
- Glucose changes into G3P
- NAD+ gains an electron and hydrogen; changes into NADH.
- NADH is sent to the Electron Transport Chain
- ADP changed into ATP; ATP is used throughout the cell
- G3P changed into pyruvic acid
- The pyruvic acid is sent to the Krebs cycle.
DIFFERENCE BETWEEN AEROBIC VS ANAEROBIC METABOLISM
- Aerobic generate more ATP and relies on oxygen
- Anaerobic does not need oxygen but only creates 2 ATP molecules per glucose
FATTY ACIDS OXIDIZED FOR ENERGY
- Beta oxidation is the initial phase; occurs in the mitochondria
- Fatty acid chains are broken apart into two-carbon acetic acid fragments and coenzymes (FAD and NAD+)
- Each acetic acid molecule is fused to coenzyme A, forming acetyl CoA
- Acetyl CoA then enters the citric acid cycle where it is oxidized to CO2 and H2O
KETONE BODIES
- acetoacetic acid
- B-hydroxybutyric acid
- acetone
KETONE STIMULUS
- Ketogenesis
- Liver converts acetyl CoA molecules to ketone bodies or ketones
- Released into the blood
DEAMINATION
- Removal of an amine group as ammonia
- Ammonia is used to synthesize urea in the liver
TRANSAMINATION
Transfer of an amine group from one amino acid to another
Used to synthesis nonessential amino acids
UREA CYCLE
- Converts excess ammonia into urea in mitochondria of liver cells
- The urea forms->enters the bloodstream -> filtered by kidneys->excreted in urine
EXCESS SUGARS CONVERTED INTO FATS
If energy is not needed
Glucose can be broken down to acetyl CoA then synthesized into triglycerides and stored