What is the MOA for beta-lactams
Interferes with cell wall synthesis
What are some examples of Beta-Lactams
Penicillin, Cephalosporins, carbapenems, monobactams
What is the MOA of Non Beta-Lactams
cell wall inhibitor
What are some examples of Non-Beta-Lactams
Vancomycin, Bacitracin, Isoniazid (INH)
What are some examples of Polymixins
Neosporin
What is the MOA for Polymixins
Damages bacterial cell membranes
What is the MOA for Fluoroquinolones?
Binding to DNA gyrase and topoimerase IV
What are some examples of Fluoroquinolones
Ciprofloxacin
What is the MOA for Aminoglycosides
Inhibits/interferes with protein synthesis
What are some examples of aminoglycosides
streptomycin
gentamicin
newer - tobramycin and aminkacin
What is the MOA for tetracycline
blocks protein synthesis by binding ribosomes
What spectrum are tetracycline
Broad spectrum
What is the MOA for chloramphenicol?
Blocks peptide bond formation and protein synthesis
What is the spectrum of Chloramphenicol
broad
very toxic
What are some examples of macrolides?
Erythromycin
Semi-synthetic - clarithromycin, azithromycin
What is the MOA for macrolides
Inhibits protein synthesis
What is the MOA for glycylcyclines
Binds 30s subunit; inhibits translation (inhibition of protein synthesis)
What are infections fought off by Glycylcycliness
MRSA and Baumanii infections
What MOA do streptogramins take
Bind 50S subunit; inhibit translation (protein synthesis inhibition)
What MOA do oxazolidines take?
Binds 50S subunit; prevents formation of 70s ribosome (Protein synthesis inhibition)
What MOA do pleuromutilins take?
inhibitor of protein Synthesis (Binds to 50S; prevents translocation)
Where do pleuromutilin take?
From the mushroom mutilus
What is the MOA for Sulfonamides
Blocks metabolic pathways
Blocks synthesis and folic acid by bacteria
What are some examples of sulfonamides
sulfisoxazole
silver sulfadiazine
Trimethoprim in combo with sulfamethoxazole