What are the different types of dementia

Alzheimer's disease, vascular dementia and lewy body dementia

Pathophysiology of Alzheimer's dementia

involves neuritic plaques (clusters of beta-amyloid protein) and tangles (accumulation of tau protein) in brain tissue, which interrupt neuron signaling, and/or alteration of neurotransmitter

What is flortaucipr F18 (Tauvid)

a radioactive imaging drug to estimate the tau protein tangles in adult patients being evaluated for alzheimer's disease

Assessment used to identify or screen for dementia

mini-mental state exam (MMSE)

(max score is 30, score <24 indicates a memory disorder)

Supplements with possible benefit for alzheimer's dementia

vitamin E (2000 IU daily) and ginkgo

(both of these increase bleeding risk)

Primary treatment for alzheimer's disease

acetylcholinesterase inhibitors

What drugs are acetylcholinesterase inhibitors

donepezil, rivastigmine, galantamine

MOA of acetylcholinesterase inhibitors

inhibit centrally-active acetylcholinesterase, the enzyme responsible for hydrolysis (breakdown) of acetylcholine, this cause an increase in acetylcholine

Brand name of donepezil

Aricept

Brand name of rivastigmine

Exelon

Brand name of galantamine

Razadyne ER

Brand name of donepezil + memantine

Namzaric

MOA of memantine

blocks NMDA receptors, which inhibits glutamate from binding and decreasing abnormal neuron activation

Brand name of memantine

Namenda

When taking donepezil, what can help decrease nausea

taking at night

Which acetylcholinesterase inhibitors comes in a patch

rivastigmine and donepezil

If stable on donepezil 10 mg, can switch to

Namzaric (memantine 7 mg/ donepezil 10 mg)

How to apply rivastigmine patch

apply new patch at the same time each day to the upper or lower back or on the upper arm or chest (do not use the same site within 14 days)

Brand name for donepezil patch

Adlarity

Where should Adlarity be stored

refrigerator

How to apply Adlarity

apply a new patch at the same time each week to the upper or lower back, upper butt or upper outer thigh (remove after 7 days)