front 1 the early events of inflammation are characterized by all except a.vasodilation b.extravasion c.apoptosis d.chemotaxis | back 1 c |
front 2 identify the mismatched pair a.MyD88:adaptor protein b.ICAM-1:LFA-1 c.CD14:LPS d.NK cells:IFN-y e.selectins:protein ligands | back 2 e |
front 3 systemic distribution of TNF-alpha in the blood circulation will cause | back 3 septic shock |
front 4 all of the following are involved in the alternative pathway of complement activation except? a.factor B b.factor D c.factor P d.C4 e.C5 | back 4 d |
front 5 which is mismatched? a.cytosol:intracellular pathogen b.surface of epithelium:extracellular pathogen c.nucleus:intracellular pathogen d.lymph:intracellular pathogen | back 5 d |
front 6 all of the following are true of some or all complement proteins except___ a. they are soluble and bind to pathogen b.they are innate immunity c.they are in extracellular fluids d.they facilitate phagocytosis of pathogens | back 6 b |
front 7 an_____ is an inactive form of an enzyme that frequently participates in a cascade of enzymatic reactions during complement activation. a.regular complement activation b.convertase c.complement control protein molecule d.zymogen | back 7 d |
front 8 defensins | back 8 vasoactive peptide facilitating the recruitment of innate immunity mediators |
front 9 cryptidins | back 9 alpha-defensins made by Paneth cells |
front 10 bradykinin | back 10 inhibits dissemination of pathogens by forming blood clots |
front 11 which of the following does not describe the outcome of complement activation? a.chemotaxis b.opsinization c.vasoconstriction d.proteolysis | back 11 c |
front 12 anaphylatoxins | back 12 induce local and systemic inflammatory responses |
front 13 properdin | back 13 protects C3bBb from protease degredation |
front 14 iC3 | back 14 binds factor B for cleavage by factor D which initiates alternative complement pathway |
front 15 C3bBb | back 15 alternative C3 converatse |
front 16 C3b2Bb | back 16 alternative C5 converatse |
front 17 C5 | back 17 inflammatory mediator and initiates membrane attack complex |
front 18 complement receptors | back 18 regulatory proteins CR1, CR3, CR4, binds C3b and stimulates phagocytosis, binds iC3 |
front 19 pathogen recognition receptors | back 19 regulatory proteins phagocytic receptors, recognize associated molecular patterns and stimulate phagocytosis |
front 20 toll-like receptors | back 20 regulatory proteins recognize pathogen associated molecular patterns and stimulate production of cytokines |
front 21 NOD-like receptors | back 21 regulatory proteins located in cytoplasm, bind products of bacterial degradation and stimulate cytokine production |
front 22 inflammasome | back 22 in response to cell stress, cleaves pro-IL-1B to active form, associates with NLRP3 and procaspase-1 |
front 23 RIG-1-like receptors | back 23 located in the cytoplasm and detect viral DNA/RNA resulting in production of cytokines esp interferons |
front 24 IL-6 | back 24 cytokine induces liver to produce and up-regulate acute phase proteins, acts on hypothalamus, fat, muscle to increase temperature of infected tissue |
front 25 CXCL8 | back 25 cytokine neutrophil chemotactic factor, up-regulates neutrophil adhesion molecules |
front 26 IL-12 | back 26 cytokine recruits NK cells |
front 27 IL-15 | back 27 cytokine activates NK cells |
front 28 IFN- alpha and beta | back 28 cytokine antiviral chemokines, activate antiviral responses |
front 29 IFN-y | back 29 cytokine activates macrophages |
front 30 NF-kB | back 30 transcription factors activates transcription of pro-inflammatory cytokines |