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Immune System

front 1

Pathogens

back 1

These are agents that cause disease, infect a wide range of animals (including humans)

front 2

Function of immune system

back 2

recognize foreign bodies and responds with the production of immune cells and proteins

front 3

Immune Cells

back 3

Get activated when there is an infection

front 4

Innate Immunity

back 4

active immediately upon infection. Present before any exposure to pathogens and is effective from the time of birth.

front 5

Adaptive Immunity

back 5

develops after exposure to agents such as microbes, toxins and other foreign substances

front 6

Where is the innate system found?

back 6

Animals and plants

front 7

First response

back 7

In vertebrates, innate immunity is a first response to infections and also serves as the foundation of adaptive immunity

front 8

Innate Immunity in invertebrates

back 8

exoskeleton made from chitin forms the barrier to pathogens

front 9

Lysozyme

back 9

enzyme that breaks down bacterial cell walls

front 10

Hemocytes

back 10

circulate within hemo-lymph and carry out phagocytes; the ingestion and digestion of foreign substances including bacteria

front 11

How does the immune system recognizes bacteria and fungi?

back 11

By the structures on their walls.

front 12

How does the immune system react to different classes of pathogens?

back 12

The Innate immune responses are different for different classes of pathogens.

front 13

What are other additional defenses unique to vertebrates?

back 13

1. natural killer cells

2. interferon

3. inflammatory response

front 14

Barrier Defenses Example

back 14

Skin doesn't allow bacteria to come inside the body

front 15

Barrier Defenses include

back 15

skin and mucous of the respiratory, urinary and reproductive tracts.

front 16

Mucous Function

back 16

trap and allow the removal of microbes

front 17

Body fluids hostile to microbes

back 17

saliva, mucus, and tears

front 18

What prevents growth of bacteria in skin and digestive system?

back 18

Low pH

front 19

Phagocytic cells

back 19

recognize groups of pathogens using toll-like receptors (TLR's)

front 20

2 types of phagocytic cells in mammals

back 20

1. Neutrophils

2. Macrophages

front 21

Neutrophils

back 21

engulf and destroy pathogens

front 22

macrophages

back 22

found throughout the body

front 23

dendritic

back 23

stimulate development of adaptive immunity

front 24

eosinophils

back 24

discharge destructive enzymes

front 25

Natural Killer Cells

back 25

detect abnormal cells and release chemicals leading to cell death

front 26

Peptides and proteins

back 26

attack pathogens or impeding their reproduction

front 27

Interferon proteins

back 27

provide innate defenses, interfering with viruses and helping active macrophages

front 28

Complement system

back 28

causes lysis of invading cells and helps trigger inflamation

front 29

Inflammatory response

back 29

brought about by molecules released upon injury of infection

front 30

histamine

back 30

triggers blood vessels to dilate and become more permeable

front 31

Cytokines

back 31

chemical signals that enhance the immune system

front 32

Septic Shock

back 32

condition caused by an overwhelming inflammatory response

front 33

Pathogens avoiding destruction

back 33

modify surfaces to prevent recognition or by resisting breakdown following phagocytosis

front 34

Adaptive Response

back 34

Receptors provide pathogen-specific recognition

front 35

T cells

back 35

mature in the thymus

front 36

B cells

back 36

mature in the bone marrow

front 37

antigens

back 37

substances that can elicit a response from a B or T cells

front 38

Epitope

back 38

small accessible part of an antigen that binds to an antigen receptor

front 39

What are B nd T cells specialized?

back 39

to recognize a specific type of molecule

front 40

Make antibodies?

back 40

B-cells