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Genetics Exam 3

front 1

Beckwith-Weidmann syndrome (BWS) is caused by a/an______

back 1

Epimutation

front 2

Which of the following provided the best evidence that changes in glucocorticoid receptor (GR)expression in rats in response to nurturing deficits early in life were epigenetic changes?

back 2

The DNA and histone modifications associated with GR expression and
behavior were heritable.

front 3

Which is the following is not a necessary feature of a good cloning vector?

back 3

The ability to carry D N A fragments of up to 200 k b

front 4

What would be the effect on the PCR reaction if any of the following circumstances arose: 1) there are no primers in the reaction, 2) there are no dNTPs in the reaction, 3) there is no Taq polymerase in the reaction?

back 4

The PCR reaction will not commence

front 5

What would be the effect on the PCR reaction if the annealing temperature was too low? Let’s say 45C

back 5

Non-specific PCR of random templates will occur

front 6

Place these steps in the correct order for a whole genome sequencing strategy:
1-Alignment
2-Shearing
3-Contig overlap
4-Gene Identification by bioinformatics
5-Sequencing

back 6

2, 5, 1, 3, 4

front 7

A gene for flower color in a wild South African lily was also found in a hybrid orchid only grown in Tokyo, Japan. Both genes control flower color, and the genes have a 68% sequence homology. What is the proper term to describe them?

back 7

Orthologs

front 8

Which of the following statements about the field of metagenomics is true?

back 8

It sequences and identifies genomes from entire communities from environmental
samples

front 9

The genetic basis for cancer is usually _____.

back 9

the accumulation of several mutations

front 10

Apoptosis _____.

back 10

is a normal response to severe D N A damage

front 11

The protein p53 _____.

back 11

may stimulate either apoptosis or the arrest of the cell cycle

front 12

Hallmarks of many cancer cells include _____

back 12

a. failure to undergo apoptosis
b. genomic instability
c. the inability to control cell division
d. reduced ability to repair D N A damage
e. All of the above