front 1 What is pharmacokinetics | back 1 what the human body does to the drug |
front 2 What is pharmacodynamics | back 2 what the drug does to the body |
front 3 When a drug is given IV, what is not required? | back 3 absorption |
front 4 Most drug absorption occurs in the | back 4 small intestine because of the large surface area and permeable membrane |
front 5 After gut absorption, the drug enters the | back 5 portal vein and travels to the liver |
front 6 Define passive diffusion | back 6 movement of drugs from an area of high concentration (the gut) to an area of lower concentration (the blood) |
front 7 Active transport occurs when | back 7 drugs are moved across the gut wall via transporter proteins that are normally used to absorb nutrients from food |
front 8 Define disintegration | back 8 when a solid oral dosage breaks into smaller pieces in the GI tract |
front 9 The smaller pieces in the disintegration process then dissolve and the active ingredient is released from the dosage from, this process is called | back 9 dissolution |
front 10 The rate of dissolution is called | back 10 Noyes-Whitney equation |
front 11 SL and ODT formulations generally have | back 11 fast absorption |
front 12 Rate of absorption by dosage form (fastest to slowest) | back 12 IV --> SL --> ODT --> immediate-release tablet --> ER tablets |
front 13 Define bioavailability | back 13 extent of drug absorption into the systemic circulation |
front 14 Bioavailability is reported as a percentage and reflects the | back 14 percentage of drug absorbed from extravascular (oral) compared to intravascular administration (IV) |
front 15 A drug with good absorption has _______ while a drug with poor absorption has _____ | back 15 high bioavailability (> 70%), low bioavailability (<10%) |
front 16 What is the calculation for absolute bioavailability | back 16 F%= 100 x AUC extravascular/AUC intravenous x Dose intravenous/ Dose extravascular |
front 17 Define distribution | back 17 NOT DONE |