Pain and inflammation management drugs
First generation NSAIDs
selective COX-2 inhibitors (celecoxib)
immune modulators (infliximab)
uric acid biosynthesis inhibitors (allopurinol)
5 cardinal signs of inflammation are:
an enzyme responsible for converting arachidonic acid into prostaglandins
aspirin is great for preventing blood clotting after an MI or stroke because it inhibits COX 1
what does first generation NSAIDs do to COX 1 and COX 2? why is that a problem
they inhibit COX 1 and COX 2. prevents blood clotting
what was the first anti-inflammatory drug? what effects does it have on the GI?
aspirin. it has irritating GI effects.
why is aspirin separate from NSAIDs?
goes around tablet that helps it to get down into the GI system before drug starts to break down
DO NOT CRUSH, CHEW, OR BREAK
SHOULD NOT BE GIVEN TO CHILDREN WITH FEVER
propionic acid derivative (ibuprofen and naproxen)
contraindications of ibuprofen
increase risk for reinfarction or death. increased risk for edema and fluid retention. NOT for patients who have had MI or CVA, because it doesn't have anticoagulant effect.
disease modifying antirheumatic drugs (DMARDS)