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34 notecards = 9 pages (4 cards per page)

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Analysis of Vaginal Secretions

front 1

bacterial vaginosis, candidiasis, and trichomonas

back 1

the three major causes of the most common gynecologic complaints: vaginal discharge, vaginal discomfort, and vaginal odor

front 2

wet mount, amine of whiff test, KOH exam, and gram stain

back 2

the four direct microscopy tests to differentiate causes of gynecologic complaints

front 3

cotton swabs

back 3

toxic to Neisseria gonorrheae

front 4

wooden shafts

back 4

toxic to Chlamydia trachomatis

front 5

Dacron swab

back 5

used for appropriate collection to obtain vaginal secretions to make sure that pathogen is not killed

front 6

3.8-4.5

back 6

usual pH of vaginal secretions

front 7

4.5

back 7

pH associated with bacterial vaginitis, trichomoniasis and atrophic vaginitis

front 8

lactobacilli

back 8

absence associated with bacterial vaginosis

front 9

wet mount

back 9

performed immediately to ensure detection of motile Trichomonas vaginalis

front 10

10%KOH

back 10

used for amine or whiff test

front 11

gram stain

back 11

performed to detect bacteria

front 12

white blood cells

back 12

present in vaginal secretions in health, but higher during ovulation and menses

front 13

red blood cells

back 13

not usually present unless during menses

front 14

large lactobacilli rods

back 14

account for 50-90% of microbes of healthy vagina; nonmotile, gram-positive that produce large amounts of lactic acid; responsible for acidic environment

front 15

yeast

back 15

visualized with KOH prep in order to lyse RBCs; seen on gram stain as gram positive organism

front 16

blastoconidium

back 16

yeast that can be present in normal vaginal secretions

front 17

candidiasis

back 17

indicated with increased (1+ or greater) of yeast or presence of hyphae or pseudohyphae

front 18

epithelial cells

back 18

predominant cell type in wet mounts of healthy vagina

front 19

clue cells

back 19

formed when numerous bacteria adhere to membranes of epithelial cells; most diagnostic indicator of bacterial vaginosis

front 20

75%

back 20

percentage of cell surface covered with bacteria for it to be called a clue cell; bacteria must also extend beyond cell's cytoplasmic borders

front 21

parabasal cells

back 21

not present in normal vaginal samples; increased in menses or postmenopausal period; seen in atrophic vaginitis and desquamative inflammatory vaginitis; oval to round with small NC ratio (1:1-2) 15-40um

front 22

basal cells

back 22

abnormal if seen in wet mount; accompanied by numerous WBCs; seen in desquamative inflammatory vaginitis

front 23

trichomonads

back 23

flagellated protozoans that infect and cause inflammation of vaginal epithelium

front 24

trichomonas vaginalis

back 24

has an optimal growth at 6.0 pH and prefers anaerobic environment; identified by jerky movement due to four anterior flagella and undulating membrane; nonmotile or dead resemble WBCs

front 25

KOH

back 25

digests cellular elements in order to visualize fungal elements

front 26

trimethylamine

back 26

released from polyamines when pH changes due to KOH produced in bacterial vaginosis in whiff test

front 27

bacterial vaginosis

back 27

most common cause of vaginal infection due to alteration in normal bacterial flora

front 28

Gardnerella vaginallis

back 28

overgrowth along with a facultative anaerobe and replaces lactobacilli leading bacterial vaginosis, most common cause of vaginal infection: foul discharge, presence of clue cells; pH usually greater than 4.5

front 29

Candidiasis (albicans)

back 29

second most common cause of vaginitis; part of normal flora, but overgrowth causes pH and normal flora changes; curdlike discharge; revealed through wet mount and KOH; normal pH and amine test negative

front 30

trichomoniasis

back 30

most common parasitic gynecologic infection; transmitted sexually, humans are only host; pH 5-6; numerous clumped WBCs, mixed bacterial flora, positive whiff; DNA probe

front 31

atrophic vaginitis

back 31

thinning of vaginal epithelium and decrease in glycogen production resulting in dryness, soreness, and spotting; pH greater than 5; treated with estrogen

front 32

fetal fibronectin (fFN)

back 32

test performed to identify possibility of preterm delivery

front 33

50ng/mL of fFN

back 33

diagnostic of higher risk of preterm labor

front 34

placental alpha microglobulin-1 (PAMG-1)

back 34

test performed to identify pregnant women for premature rupture of fetal membranes; increased amount indicates increased risk