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49 notecards = 13 pages (4 cards per page)

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Chapter 6, Carbohydrates

front 1

The major ________ of carbohydrates are based on 4 criteria:

-The number of carbons in the chain
-The size of the carbon chain
-The location of the carbonyl group (-CO)
-Stereoisomers

back 1

Classes

front 2

Molecules that have the same empirical or chemical formula but have mirror image structural formulas:

back 2

Stereoisomers

front 3

The digestion of carbohydrates begins in the mouth with the enzyme __________.

back 3

Amylase

front 4

The enzyme that continues the digestion of carbs in the pancreas:

back 4

Pancreatic amylase

front 5

Maltose, lactose, and sucrose are digested by the intestinal _________.

back 5

Mucosa

front 6

After the carbs are digested in the intestine, they are transported to the _______ by the portal vein.

back 6

Liver

front 7

Glucose ----> Glycogen (for storage)

back 7

Glycogenesis

front 8

Glycogen ----> Glucose (need more usable sugar)

back 8

Glycogenolysis

front 9

Formation of glucose from non-carbohydrate sources

back 9

Gluconeogenesis

front 10

Breakdown of glucose for energy. Produces lactate or pyvuvate then CO2 and H2O. Gives off ATP.

back 10

Glycolysis

front 11

Gylcogenesis and Glycolysis _________ serum glucose levels

back 11

Decrease

front 12

Glycogenolysis and Gluconeogenesis __________ serum glucose levels

back 12

Increase

front 13

A carbohydrate metabolic pathway; glycolysis of glucose, results in pyruvate or lactate and can occur without oxygen

back 13

Embden-Meyerhoff pathway

front 14

A carohydrate metabolic pathway; Oxidation of glucose results in ribose and CO2

back 14

Hexose-Monophosphate pathway/shunt

front 15

________ Diabetes is characterized by:

Abrupt onset
Absolute insulin deficiency
Ketosis-prone
80-90% have autoantibodies to islet cells

back 15

Type 1

front 16

________ Diabetes is characterized by:

Insidious onset (Gradual)
Relatively low insulin deficiency
Non-ketosis prone
Obesity
Glucosuria

back 16

Type 2

front 17

The release of the _________ hormone, glucagon, is stimulated by a decrease in glucose levels.

back 17

Pancreatic

front 18

In order to diagnose Diabetes Mellitus (DM) plasma glucose levels (and 2-hour post-load glucose levels) should be above or equal to

back 18

200 mg/dL

front 19

In order to diagnose Diabetes Mellitus (DM) fasting plasma glucose (FPG) levels should be at or above

back 19

126 mg/dL

front 20

________ triad:

-Signs and symptoms of hypoglycemia
-Documentation of low plasma glucose at the time patient is experiencing the signs and symptoms
-Alleviation of symptoms the the ingestion of glucose and an increase in plasma glucose

back 20

Whipple's

front 21

In the Glucose Oxidase method:

Glucose oxidase catalyzes the conversion of glucose to _________ acid and hydrogen peroxide. The hydrogen peroxide and a reduced chromogen react to create color, which is measured in proportion to glucose concentration

back 21

Gluconic

front 22

In the Hexokinase method:

Glucose is phosphorylated by hexokinase to form G6P, which is oxidized by G6PDH, which produces ______. The concentration of this causes an increase in absorbance that is proportional to glucose concentration.

back 22

NADH

front 23

Fasting serum and plasma glucose levels are approximately:

back 23

70-99 mg/dL

front 24

The reference range for the Hexokinase method is:

back 24

70-105 mg/dL

front 25

In what form is glucose stored in the liver?

back 25

Glycogen

front 26

What hormone has the ability to decrease blood glucose concentration?

back 26

Insulin

front 27

Which is the primary hyperglycemic hormone?

back 27

Glucagon

front 28

What test may be performed to assess the average blood glucose level that an individual maintained during the previous 2 to 3 month period?

back 28

Glycohemoglobin

front 29

The position of the hydroxyl group on the carbon next to the bottom CH2OH on a carbon chain

back 29

D(Right) or L(Left)

front 30

A molecule composed of a glucose attached to a fructose

back 30

Sucrose

front 31

A molecule composed of a glucose attached to galactose

back 31

Lactose

front 32

A molecule composed of two glucose molecules, that cannot be reduced

back 32

Maltose

front 33

________ is the plant form of carbohydrate storage

back 33

Starch

front 34

Glycogen is the _______ form of carbohydrate storage

back 34

Animal

front 35

Hexose monophosphate shunt provides _______ that protects the RBCs from oxidative damage.

back 35

NADPH

front 36

Which is a monosaccharide?

Sucrose, Fructose, Lactose, Maltose

back 36

Fructose

front 37

Insulin is produced in the _____ cells of the pancreatic Islets of Langerhans

back 37

Beta

front 38

Glucagon is produced in the _______ cells of the pancreas

back 38

Alpha

front 39

Inhibits insulin secretion, stimulates glycogenolysis and lipolysis. Triggered by stress.

back 39

Epinephrine/Adrenaline

front 40

A hormome, also known as T4, that promotes glycogenolysis

back 40

Thyroxine

front 41

Growth hormone, ACTH, and Cortisol are all ______________ to insulin.

back 41

Antagonistic

front 42

____________ diabetes is characterized by:

Onset during pregnancy
Large babies
Babies with severe hypoglycemia after birth

back 42

Gestational

front 43

The test for glucose in urine

back 43

Clinitest

front 44

The gray-top plasma tube is used for measuring ______. It has sodium fluoride in it that inhibits glycolysis.

back 44

Glucose

front 45

Insulinoma, Early Type 2 Diabetes, and Ethanol may all result in _____________.

back 45

Hypoglycemia

front 46

What type of hypoglycemia follows a meal?

back 46

Reactive

front 47

What product reacts with the chromogen in the Glucose Oxidase methodology

back 47

Hydrogen Peroxide

front 48

If a patient's serum glucose is 85 mg/dL, a _____ glucose concentration of 60 mg/dL would be considered considered normal

back 48

CSF

front 49

What is the cut-off value for HbA1C recommended by the American Diabetes Association for adequate control of blood glucose

back 49

7%