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Bio 201 Peripheral Nervous System

front 1

What makes up the Peripheral Nervous System and the Central Nervous System? Be sure to include ALL of the subdivisions.

back 1

Central Nervous System (CNS) –

–Brain and spinal cord

Peripheral Nervous System (PNS) –

–Made up of nerves that attach to CNS

arms, legs, hands, and feet

Subdivisions of the PNS include the Somatic nervous system and the autonomic nervous system.

front 2

Review the arrangement of sensory, motor, and association neurons.

back 2

Sensory – transmit impulses from skin or other organs toward CNS

Motor – carry impulses away from CNS to effector organs

Association (interneurons) – lie between motor and sensory neurons

front 3

Compare and contrast afferent and efferent transmission.

back 3

no data

front 4

Compare and contrast the somatic and autonomic nervous system in terms of structure AND function. Somatic Nervous System

back 4

Controls voluntary and involuntary skeletal muscle contractions

Involuntary skeletal contraction – reflex

Single neuron system

front 5

Compare and contrast the somatic and autonomic nervous system in terms of structure AND function. Autonomic Nervous System

back 5

Controls activity of smooth and cardiac muscles

2 neuron system

  • 1st: from CNS to ganglion
  • 2nd: from ganglion to effector

front 6

What is the name given to the branch of the nervous system that is responsible for the fight or flight response mechanism?

back 6

Sympathetic division

front 7

What is the name given to the branch of the nervous system that is responsible for resting and digesting?

back 7

Parasympathetic division

front 8

Describe the main differences between the sympathetic nervous system and parasympathetic nervous system. List multiple examples of what each system does. Sympathetic Nervous System

back 8

“ Fight or flight” response

Release adrenaline and noradrenaline

Increases heart rate and blood pressure

Increases blood flow to skeletal muscles

Sweat gland activated

Inhibits digestive functions

front 9

Describe the main differences between the sympathetic nervous system and parasympathetic nervous system. List multiple examples of what each system does. Parasympathetic Nervous System

back 9

“ Rest and digest ” system

Salivary and digestive glands activated

Urination and defecation stimulated

Calms the rest of the body to conserve and maintain energy

Lowers heartbeat, breathing rate, blood pressure

front 10

Diagram AND label the arrangement of a preganglionic fiber, ganglion cell, postganglionic fiber, and effector organ. Make sure to include the synapses!

back 10

front 11

Describe the arrangement, including lengths, of preganglionic and postganglionic fibers in the sympathetic nervous system.

back 11

Preganglionic fibers are SHORT

Postganglionic fibers are LONG

Preganglionic neurons located between segments T1 and L2 of spinal cord

front 12

Compare and contrast the locations, targets, AND functions of sympathetic chain ganglia, collateral ganglia, and ganglia found in the adrenal medulla.

back 12

The Sympathetic chain ganglia innervates visceral effectors via spinal nerves and also innervates visceral organs in the thoracic cavity via sympathetic nerves.

Target organs are visceral effectors in the thoracic cavity, head, body wall, and limbs.

front 13

Compare and contrast the locations, targets, AND functions of sympathetic chain ganglia, collateral ganglia, and ganglia found in the adrenal medulla.

back 13

The collateral ganglia innervates visceral effectors in the abdominal cavity.

front 14

Compare and contrast the locations, targets, AND functions of sympathetic chain ganglia, collateral ganglia, and ganglia found in the adrenal medulla.

back 14

Targets are organs and systems throughout the body.

It secretes neurotransmitters into general circulation.

front 15

Describe the arrangement, including lengths, of preganglionic and postganglionic fibers in the parasympathetic nervous system.

back 15

Preganglionic fibers are LONG

Postganglionic fibers are SHORT

Preganglionic fibers originate in brain stem and sacral segments of spinal cord

front 16

Compare and contrast the locations, targets, AND functions of the ganglia in the parasympathetic nervous system.

back 16

front 17

What is the neurotransmitter involved at the synapse between the preganglionic and postganglionic cells of BOTH the sympathetic and parasympathetic nervous system?

back 17

Ach

front 18

Diagram the neurotransmitters involved between the postganglionic cell and the target organ/gland in BOTH the sympathetic and parasympathetic nervous system.

back 18

front 19

Compare and contrast the locations and functions of nicotinic and muscarinic acetylcholine receptors.

back 19

***Nicotinic R eceptors

–On surfaces of ALL ganglion cells (sympathetic AND parasympathetic)

–ALSO found at the NEUROMUSCULAR JUNCTION in the SOMATIC NERVOUS SYSTEM

***Muscarinic Receptors

–At the neuromuscular or neuroglandular junctions (parasympathetic)

–At few cholinergic junctions (sweat glands innervated by the sympathetic nervous system)

front 20

Describe the pathophysiology of BOTH nicotine poisoning and muscarine poisoning. Ask yourself WHY a person would experience the symptoms associated with each type of poisoning. Think of what is happening at the receptors! NICOTINE POISONING

back 20

Nicotine:

–binds to nicotinic receptors

–targets autonomic ganglia and skeletal neuromuscular junctions

Symptoms:

–vomiting, diarrhea, high blood pressure, rapid heart rate, sweating, profuse salivation, convulsions

  • May result in coma or death

front 21

Describe the pathophysiology of BOTH nicotine poisoning and muscarine poisoning. Ask yourself WHY a person would experience the symptoms associated with each type of poisoning. Think of what is happening at the receptors! MUSCARINE POISONING

back 21

Muscarine:

–binds to muscarinic receptors

–targets parasympathetic neuromuscular or neuroglandular junctions

Symptoms:

–salivation, nausea, vomiting, diarrhea, constriction of respiratory passages, low blood pressure, slow heart rate (bradycardia)

front 22

What does adrenergic mean?

back 22

Aka SYMPATHOMIMETIC

Activated by, characteristic of, or secreting epinephrine, or substances with similar activity

front 23

Compare and contrast the following receptors, in detail:

  1. Alpha 1
  2. Alpha 2

back 23

Alpha-1 ( a 1 )

–More common type of alpha receptor

–Releases intracellular calcium ions from reserves in endoplasmic reticulum

–What will this do to the smooth muscle cells in the wall of an artery? Vasoconstrict

Alpha-2 ( a 2 )

–Suppresses release of epinephrine

–Can lead to vasodilation of blood vessels

front 24

Compare and contrast the following receptors, in detail:

  1. Beta 1
  2. Beta 2

back 24

Affect membranes in many organs (skeletal muscles, lungs, heart, and liver)

Beta-1 ( b 1 )

–Increase in heart rate (chronotropy) and strength of contractions (ionotropy)

Beta-2 ( b 2 )

–Triggers relaxation of smooth muscles along respiratory tract and wall of uterus

Beta-3 ( b 3 )

–Is found in adipose tissue

–Leads to lipolysis, the breakdown of triglycerides in adipocytes

–Releases fatty acids into circulation

front 25

Why does Primack’s wife carry an epi-pen with her? Hint: Bees!

Why would a person with heart disease (a damaged heart muscle) take Atenolol (a b-1 Antagonist) – commonly called a Beta Blocker?

Why else might someone be prescribed Atenolol on a PRN (as needed) basis?

Why would a person having an asthma attack take Albuterol (a b-2 Agonist)? Why does their heart race increase when taking this drug????????? Would you expect this to happen? Why or why not?

Why would a female be administered terbutaline (a b-2 Agonist) during pregnancy?

Come up with two different ways to pharmacologically treat hypertension using drugs which target adrenergic receptors

back 25

Review

front 26

Autonomic Innervation: The Heart

back 26

Receives dual innervation

2 divisions have opposing effects:

–parasympathetic division:

  • acetylcholine released by postganglionic fibers slows in heart rate

–sympathetic division:

  • NE released accelerates heart rate
  • Balance between 2 divisions:

–autonomic tone is present

–releases small amounts of both neurotransmitters continuously

–Parasympathetic innervation dominates under resting conditions

Crisis accelerates heart rate by:

–stimulation of sympathetic innervation

inhibition of parasympathetic innervation

front 27

Autonomic Innervation: Blood Vessel Dilation

back 27

Blood vessel dilates and blood flow increases

Blood vessel constricts and blood flow reduced

Sympathetic postganglionic fibers release NE:

–innervate smooth muscle cells in walls of peripheral vessels

Background sympathetic tone keeps muscles partially contracted

To increase blood flow:

–rate of NE release decreases

–smooth muscle cells relax

–vessels dilate and blood flow increases