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Phys 10

front 1

A normal heartbeat is initiated in the:

A. SA node
B. AV node
C. AV bundle
D. Purkinje fibers

back 1

A. SA node

front 2

After originating in the sinus node, the impulse next normally travels to the:

A. bundle branches
B. Purkinje network
C. AV node
D. ventricular myocardium

back 2

C. AV node

front 3

At the AV node, impulses are normally:

A. accelerated
B. delayed
C. blocked
D. amplified

back 3

B. delayed

front 4

The AV bundle normally conducts impulses from the:

A. ventricles to atria
B. SA node to atria
C. Purkinje fibers to apex
D. atria into ventricles

back 4

D. atria into ventricles

front 5

The right and left bundle branches ultimately distribute impulses to:

A. both atria
B. all ventricular regions
C. the AV valves
D. the sinus node

back 5

B. all ventricular regions

front 6

The sinus node is located in the:

A. superior posterolateral right atrium
B. inferior left atrial wall
C. interventricular septum
D. coronary sinus opening

back 6

A. superior posterolateral right atrium

front 7

Relative to the superior vena cava opening, the sinus node lies:

A. medial and above
B. anterior and below
C. posterior and medial
D. below and lateral

back 7

D. below and lateral

front 8

Sinus nodal fibers connect directly to atrial muscle fibers so that:

A. ventricular filling begins sooner
B. AV delay becomes longer
C. atrial depolarization spreads immediately
D. semilunar valves open earlier

back 8

C. atrial depolarization spreads immediately

front 9

Some cardiac fibers can spontaneously depolarize, producing rhythmic discharge. This property is called:

A. self-excitation
B. conduction delay
C. summation
D. tetany

back 9

A. self-excitation

front 10

The resting membrane potential of sinus nodal fibers is normally closest to:

A. -90 to -95 mV
B. -55 to -60 mV
C. -40 to -45 mV
D. +20 to +15 mV

back 10

B. -55 to -60 mV

front 11

Sinus nodal cells are less negative than ventricular cells mainly because they are naturally leaky to:

A. potassium and chloride
B. calcium and potassium
C. sodium and potassium
D. sodium and calcium

back 11

D. sodium and calcium

front 12

Which list correctly names the three main cardiac ion channels?

A. chloride, sodium, magnesium
B. calcium, chloride, funny
C. fast sodium, L-type calcium, potassium
D. sodium-potassium pump, chloride, calcium

back 12

C. fast sodium, L-type calcium, potassium

front 13

Because the sinus node membrane potential is less negative, which channels remain closed during nodal action potential generation?

A. potassium channels
B. fast sodium channels
C. chloride channels
D. ryanodine channels

back 13

B. fast sodium channels

front 14

The sinus nodal action potential upstroke is slower than ventricular muscle because nodal cells rely mainly on:

A. slow sodium-calcium channels
B. fast sodium channels
C. inward rectifier potassium
D. chloride influx

back 14

A. slow sodium-calcium channels

front 15

Between heartbeats, the slow rise in sinus nodal resting membrane potential is caused mainly by:

A. potassium leaving the cell
B. calcium sequestration into SR
C. sodium influx
D. chloride influx

back 15

C. sodium influx

front 16

When sinus nodal membrane potential reaches threshold, about _____, L-type calcium channels open.

A. -90 mV
B. -60 mV
C. 0 mV
D. -40 mV

back 16

D. -40 mV

front 17

The self-excitation of sinus nodal fibers is due primarily to their

A. inherent leakiness
B. prolonged refractory period
C. high contractile force
D. dense fast sodium current

back 17

A. inherent leakiness

front 18

To avoid remaining continuously depolarized, sinus nodal fibers do which of the following?

A. open fast sodium channels, lose potassium
B. inactivate calcium channels, lose potassium
C. close potassium leak channels, lose potassium
D. activate chloride influx, lose potassium

back 18

B. inactivate calcium channels, lose potassium

front 19

Which additional event helps terminate the sinus nodal action potential and prevent persistent depolarization?

A. sodium retention in cell
B. calcium influx acceleration
C. chloride entry
D. potassium diffusion outward

back 19

D. potassium diffusion outward

front 20

Excess negativity developing inside the fiber after repolarization is called:

A. depolarization
B. afterdepolarization
C. hyperpolarization
D. automaticity

back 20

C. hyperpolarization

front 21

Which sequence best describes the sinus node action-potential process?

A. Self-excitation, recovery, hyperpolarization, threshold drift, re-excitation
B. Recovery, depolarization, threshold drift, hyperpolarization, re-excitation
C. Hyperpolarization, recovery, self-excitation, threshold drift, re-excitation
D. Threshold drift, self-excitation, recovery, re-excitation, hyperpolarization

back 21

A. Self-excitation, recovery, hyperpolarization, threshold drift, re-excitation

front 22

Rapid activation of the left atrium after sinus node discharge is aided most directly by the:

A. middle internodal tract
B. posterior internodal tract
C. AV bundle
D. anterior interatrial band

back 22

D. anterior interatrial band

front 23

Which tracts conduct impulses from the SA node to the AV node?

A. anterior, lateral, septal pathways
B. anterior, middle, posterior internodal pathways
C. left, right, posterior bundle branches
D. Bachmann, Purkinje, nodal tracts

back 23

B. anterior, middle, posterior internodal pathways

front 24

Which structure primarily delays transmission before impulses enter the ventricles?

A. SA node
B. AV bundle
C. AV node
D. Purkinje fibers

back 24

C. AV node

front 25

During EP mapping, a conduction structure is identified in the posterior wall of the right atrium behind the tricuspid valve. This is the:

A. AV node
B. SA node
C. coronary sinus
D. bundle branch

back 25

A. AV node

front 26

The total delay in the AV node plus AV bundle is closest to:

A. 0.03 seconds
B. 0.16 seconds
C. 0.13 seconds
D. 0.30 seconds

back 26

C. 0.13 seconds

front 27

The conduction delay between the sinus node and AV node is approximately:

A. 0.13 seconds
B. 0.10 seconds
C. 0.16 seconds
D. 0.03 seconds

back 27

D. 0.03 seconds

front 28

The total delay before the excitatory signal reaches contracting ventricular muscle is about:

A. 0.13 seconds
B. 0.16 seconds
C. 0.03 seconds
D. 0.30 seconds

back 28

B. 0.16 seconds

front 29

Slow conduction through nodal tissue occurs mainly because of diminished numbers of:

A. gap junctions
B. sodium channels
C. myofibrils
D. T tubules

back 29

A. gap junctions

front 30

Which fibers continue from the AV node through the AV bundle into the ventricles?

A. atrial conducting fibers
B. internodal bands
C. papillary fibers
D. special Purkinje fibers

back 30

D. special Purkinje fibers

front 31

Purkinje fibers are best described as:

A. small fibers, rapid contraction
B. nonconducting myocardial cords
C. large fibers, fast conduction
D. thin fibers, slow conduction

back 31

C. large fibers, fast conduction

front 32

The conduction velocity in Purkinje fibers is closest to:

A. 0.3 to 0.5 m/sec
B. 1.5 to 4.0 m/sec
C. 4.5 to 6.0 m/sec
D. 0.03 to 0.13 m/sec

back 32

B. 1.5 to 4.0 m/sec

front 33

Rapid Purkinje transmission is attributed mainly to the very high permeability of:

A. gap junctions at discs
B. L-type calcium channels
C. fast sodium channels
D. potassium leak pores

back 33

A. gap junctions at discs

front 34

Purkinje fibers contract very little during impulse transmission because they contain few:

A. intercalated discs
B. mitochondria
C. T tubules
D. myofibrils

back 34

D. myofibrils

front 35

Which statement is a special characteristic of the AV bundle?

A. It conducts only retrograde impulses
B. It lies within atrial free wall
C. Impulses normally cannot travel backward
D. It is the main pacemaker

back 35

C. Impulses normally cannot travel backward

front 36

The only site where atrial muscle is not separated from ventricular muscle is the:

A. AV node
B. AV bundle
C. Purkinje network
D. SA node

back 36

B. AV bundle

front 37

The continuous fibrous barrier between atrial and ventricular muscle normally acts as an:

A. insulator
B. amplifier
C. pacemaker
D. depolarizer

back 37

A. insulator

front 38

The left and right bundle branches travel primarily:

A. upward toward the base
B. laterally into the atria
C. downward toward the apex
D. posteriorly to the vena cava

back 38

C. downward toward the apex

front 39

The terminal Purkinje fibers penetrate into the ventricular muscle mass approximately:

A. halfway through myocardium
B. to the epicardium only
C. through the full thickness
D. one-third of the way

back 39

D. one-third of the way

front 40

A lesion affecting the fibrous insulating barrier but sparing the AV bundle would most likely alter which normal property of the heart?

A. Purkinje automaticity
B. electrical separation of atria and ventricles
C. atrial depolarization by SA node
D. ventricular repolarization pattern

back 40

B. electrical separation of atria and ventricles

front 41

The gross arrangement of cardiac muscle around the heart is best described as a:

A. double spiral
B. circumferential ring
C. radial lattice
D. single helix

back 41

A. double spiral

front 42

Between the spiraling layers of cardiac muscle lie:

A. Purkinje sheets
B. elastic laminae
C. AV nodal bands
D. fibrous septa

back 42

D. fibrous septa

front 43

The total time for impulse transmission from the bundle branches to the last ventricular muscle fibers is closest to:

A. 0.16 seconds
B. 0.03 seconds
C. 0.06 seconds
D. 0.13 seconds

back 43

C. 0.06 seconds

front 44

If isolated from faster pacemakers, AV nodal fibers typically discharge at an intrinsic rate of:

A. 15-40/min
B. 40-60/min
C. 70-80/min
D. 100-120/min

back 44

B. 40-60/min

front 45

Purkinje fibers, when acting as an intrinsic pacemaker, usually discharge at:

A. 15-40/min
B. 40-60/min
C. 70-80/min
D. 90-110/min

back 45

A. 15-40/min

front 46

The normal discharge rate of the sinus node is about:

A. 15-40/min
B. 40-60/min
C. 70-80/min
D. 90-100/min

back 46

C. 70-80/min

front 47

The SA node normally controls cardiac rhythmicity primarily because it has the:

A. longest refractory period
B. highest discharge rate
C. greatest contractile force
D. slowest conduction velocity

back 47

B. highest discharge rate

front 48

A pacemaker located anywhere other than the sinus node is called an:

A. escape focus
B. reentry circuit
C. ectopic pacemaker
D. nodal bypass tract

back 48

C. ectopic pacemaker

front 49

Blockage of cardiac impulse transmission can cause a:

A. shift of pacemaker
B. stronger SA discharge
C. shorter refractory period
D. loss of ventricular systole

back 49

A. shift of pacemaker

front 50

AV block refers to failure of the cardiac impulse to pass from the:

A. ventricles to atria
B. bundle branches to Purkinje
C. atria to ventricles
D. SA node to atria

back 50

C. atria to ventricles

front 51

In complete AV block, which chambers continue to beat at their own normal rhythm?

A. ventricles
B. atria
C. both equally
D. neither chamber

back 51

B. atria

front 52

In AV block, the structure that usually becomes the pacemaker for the ventricles is the:

A. SA node
B. atrial muscle
C. AV bundle only
D. Purkinje system

back 52

D. Purkinje system

front 53

A patient with complete AV block briefly has no effective ventricular rhythm before a slow escape rhythm appears. This delay occurs because the Purkinje fibers are initially:

A. overstimulated
B. depolarized maximally
C. in a suppressed state
D. blocked by acetylcholine

back 53

C. in a suppressed state

front 54

In Stokes-Adams syndrome, the Purkinje system may fail to begin firing for approximately:

A. 1-2 seconds
B. 5-20 seconds
C. 20-40 seconds
D. 40-60 seconds

back 54

B. 5-20 seconds

front 55

A patient with sudden complete AV block loses consciousness after a few seconds because cerebral blood flow ceases. Syncope usually occurs after about:

A. 1-2 seconds
B. 8-10 seconds
C. 12-15 seconds
D. 4-5 seconds

back 55

D. 4-5 seconds

front 56

The delayed pickup of ventricular beating after AV block is called:

A. ventricular fibrillation
B. Wenckebach phenomenon
C. Stokes-Adams syndrome
D. pulsus alternans

back 56

C. Stokes-Adams syndrome

front 57

Parasympathetic fibers to the heart are distributed mainly to the:

A. SA and AV nodes
B. ventricular free walls
C. bundle branches
D. Purkinje network

back 57

A. SA and AV nodes

front 58

Sympathetic fibers are distributed to:

A. only the atria
B. all parts of heart
C. only SA node
D. only ventricles

back 58

B. all parts of heart

front 59

The main neurotransmitter mediating parasympathetic control of the heart is:

A. epinephrine
B. dopamine
C. acetylcholine
D. serotonin

back 59

C. acetylcholine

front 60

Parasympathetic stimulation has two major cardiac effects: decreased SA nodal rate and decreased excitability of the:

A. Purkinje fibers
B. ventricular myocardium
C. bundle branches
D. AV junctional fibers

back 60

D. AV junctional fibers

front 61

Ventricular escape refers to the ability of the Purkinje fibers to:

A. block atrial conduction
B. pace ventricles independently
C. increase SA discharge
D. shorten AV delay

back 61

B. pace ventricles independently

front 62

Acetylcholine released from vagal nerves greatly increases membrane permeability to:

A. sodium ions
B. calcium ions
C. chloride ions
D. potassium ions

back 62

D. potassium ions

front 63

Sympathetic stimulation of the heart causes increased SA discharge, increased conduction, and increased:

A. force of contraction
B. vagal tone
C. potassium efflux
D. AV nodal delay

back 63

A. force of contraction

front 64

Stimulation of sympathetic cardiac nerves releases:

A. epinephrine
B. acetylcholine
C. norepinephrine
D. dopamine

back 64

C. norepinephrine

front 65

Norepinephrine exerts its main cardiac effects through:

A. alpha-1 receptors
B. muscarinic receptors
C. beta-2 receptors
D. beta-1 receptors

back 65

D. beta-1 receptors

front 66

Sympathetic stimulation increases membrane permeability primarily to:

A. potassium and chloride
B. sodium and calcium
C. calcium and chloride
D. sodium and potassium

back 66

B. sodium and calcium