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1.4 Acid Base and Fluids Balance in Hospitals

front 1

Osmoles definition

back 1

Measure of the number of osmotically active particles in solution

front 2

Molarity defitnition

back 2

Number of moles of a substance in a solution

front 3

Water Distribution (in health)

back 3

Roughly a rule of 1/3rds…

- 2/3rds of total body mass in water

- 1/3rd of this is in the extra-cellular compartment

- 1/3rd of this is in the intra-vascular compartment

front 4

Standard formula for IV fluids regime

back 4

  • 4ml/kg/hr for the 1st 10kg
  • 2ml/kg/hr for the 2nd 10kg
  • 1ml/kg/hr for every kg after that

front 5

Loss in fever (sweat)

back 5

Water

NaCl

front 6

Loss in DM (Urine)

back 6

Glucose, water, KCl, NaCl, phosphate

front 7

Loss in vomitting (gastric content)

back 7

HCl and water, KCl

front 8

Loss in diarrhoea (faeces)

back 8

water, KCl, NaCl

front 9

Loss in Burns (plasma, evaporation)

back 9

Protein, water, NaCl

front 10

Ileostomy losses (ileal fluid)

back 10

water, NaCl

front 11

Haemorrhage losses (blood)

back 11

RBCs all electrolytes

front 12

Diabetes insipidus losses (urine)

back 12

water

front 13

Addisons or diurteics use losses (urine)

back 13

NaCl, water

front 14

sepsis, cirrhosis (third space)

back 14

Protein Nacl, water

front 15

When do need to be cautious when giving fluids and consider individualisation of fluids regimes

back 15

  • Elderly (20-25 ml/kg/day)
  • obese (use IBW and don't go over 3L/ day)
  • Heart failure
  • renal failure
  • liver failure (low albumin)
  • oedema
  • electrolytes derangement

front 16

Assessing fluids requirements

back 16

  • History
  • examination
  • Bedside tests
  • Investigations
  • Normal or altered physiology
  • Individual differences
  • co- morbidities
  • iatrogenic drugs
  • Re-assess post-interventions

front 17

Hypovolemia (assessing fluid requirements)

back 17

clinical

  • thirst
  • cool extremities
  • hypotension
  • increased RR
  • Tachycardia
  • increased capillary refill time
  • reduced UO
  • reduced GCS
  • loss of skin turgor
  • Absence of JVP patient at 45 degrees
  • Postural BP drop
  • fluid balance charts

Biochemical

  • FBC (hematocrit)
  • raised urea/ creatine
  • Hyperkalemia/ natremmia
  • Hypercalcemia/ meatbolic acidosis
  • raised BM/Ca2+
  • CVP need cenral line
  • esophgal doppler
  • EchoCardiogram (collapse of LV)

front 18

Hypervolemia (assessing fluid requiremints)

back 18

Symptoms/Signs

  • Raised JVP, patient at 45°
  • Generalised oedema
  • Increased weight (need baseline)
  • Ascites
  • Pulmonary oedema
  • Increased RR
  • Crackles
  • Orthopnoea
  • Fluid balance charts

Biochemical

  • Blood tests
  • Raised urea/creatinine (often reflects CRF)
  • Raised LFTs (hepatic congestion)
  • Hyponatraemia
  • CVP Need a central line
  • Oesophageal doppler
  • Echocardiogram ( ?reduced LVEF, RWMA, Distended RV)

front 19

Delivery mothods of IV fluids

back 19

Peripheral

◼ Venous cannula (Venflons)

◼ Intra-osseous

◼ (Subcutaneous)

Central access:

◼ Central line

◼ Jugular, femoral, subclavian

◼ Peripherally-inserted central catheter (PICC)

◼ Hickman (tunnelled-line)

◼ Port-a-cath. Subcutaneous, accessible, needle-able reservoir

front 20

Complications of Peripheral lines

back 20

◼ Extravasation

◼ Thrombosis of peripheral veins

◼ Infection – phlebitis / cellulitis (VIP score to monitor, ANTT)

◼ Air embolism

front 21

central line complications

back 21

◼ Mis-insertion: pneumothorax, arterial bleed / dissection

◼ Infection – particular concern re: septic emboli / endocarditis

◼ Thrombosis and embolism

◼ Embolisation of the line

◼ Erosion

◼ Air embolism

front 22

Prescribing

Drug Chart

back 22

◼ Dedicated section

◼ Can also be written on Once Only/Stat section

◼ State

◼ Type of fluid

◼ Volume

◼ Drugs/Electrolytes to be added

◼ Rate (mls/hr) AND/OR time to be given over

◼ (Signature + bleep)

front 23

Prescribing

Notes

back 23

◼ Intention

◼ The intended fluid/electrolyte prescription over the next 24hrs

◼ Targets e.g.

◼ What to do if these are NOT met (for on-call Dr)

◼ Cautions/review points e.g.

front 24

Crystalloid pros and cons

back 24

Pros

◼ Safe (save AE determined by volume/electrolytes)

◼ Cheap

◼ Constituents determine distribution

◼ Na+ - ECF, Dextrose – ECF/ICF

Cons

◼ Remain in the intravascular space for less time (~45mins)

◼ Thus need greater volume to achieve effect (3-4L crystalloid/1L blood)

front 25

colloid pros and cons

back 25

Pros

◼ Remain in the intravascular space (dependent on MW)

◼ Can act as ‘plasma expanders’

Cons

◼ Cost

◼ ‘Hidden’ electrolytes

◼ Potential allergens

◼ Effect coagulation (increased bleeding risk in high doses)

◼ Renal: (predominantly HES)(Osmotic nephrosis,Failure)

front 26

common crystalloid fluids

back 26

  1. Saline (0.9, 0.18, 1.8 %NaCl)
  2. Hartmanns (Na lactate)
  3. Sugar (5, 10 , 20, 50%)
  4. Bicarbonates (NaHCO3) (1.26, 8.4%)

front 27

electrolytes are normally added to

back 27

saline/sugar

front 28

common colloid fluids

back 28

  1. gelatins
  2. starches
  3. blood products (FFP, Packed cells, albumin(HAS 4.5%, 20%), cryoprecipitate)

front 29

What is in Hartmanns (mmol/l)

back 29

  • the physiological fluid
  • Na 131
  • Cl 111
  • K 5 > not significant, caustiond (CRF, AKI)
  • Ca 2
  • Lactate 29 > metabolised to HCO3 managed by liver, caustions (LF, DKA)

front 30

Why Fluid Challenge?

back 30

  • Achieve a small but rapid increase in intravascular volume
  • to assess the whether the patient is hypovolaemic and would benefit from further IV fluids

How:

◼passive leg raise

◼ Fluid challenge (Deliver 250-500mls fluid via a largish-bore cannula over 5mins)

Assess

◼ Clinical measures e.g. JVP/lungs/RR/HR/BP/UO

◼ Ideally: CVP, oesophogeal doppler

◼ NOT: Increase maintenance fluids