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pharmacology chapter 45 part one

front 1

multi drug resistant

back 1

mrsa,vre,esbls,cre

front 2

Aminoglycosides very mean to organ

back 2

bactericidal drug , no oral absorption, no oral forms except neomycin,very potent antibiotic, with serious toxicities

front 3

what kills mostly gram negative: some gram positive bacteria

back 3

Aminoglycosides

front 4

what medicines are Aminoglycosides

back 4

gentamicin, neomycin,Tobramycin,Amikacin

front 5

where is aminoglycosides poorly absorbed at

back 5

through the gi track except neomycin

front 6

how should you give aminoglycosides

back 6

parenterally

front 7

how can you give neomycin A form of Aminoglycosides

back 7

you can only give this one orally or as an enema

front 8

why is neomycin given

back 8

to decontaminate the gi tract before surgical procedures

as use as an enema for this purpose

its used to treat hepatic encephalopathy

front 9

what happens when taking aminoglycosides while pregnant category c and d?

back 9

can cross the placenta and cause fetal harm you must be caution and d for danger it can be distributed in breast milk, should not be used by lactating women

front 10

how should vancomycin be infused

back 10

should be infused over 60 minutes

rapid infusions may cause hypotension

front 11

something you can get from vancomycin

back 11

red man syndrome may occur

front 12

client teaching -Vancomycin

back 12

report any changes in hearing such as ringing in the ears or a feeling of fullness in the ears monitor serum levels through out therapy

front 13

what should vanco levels be at

back 13

5 to 15

front 14

client teaching about clindamycin

back 14

if clindamycin gets in eyes rinse with alot of water

do not use near eyes or near any abraded areas to avoid tissue iritatations, with vaginal dose forms do not engage in sexual intercourse for the duration of therapy

front 15

what are client teaching with Quinolones

back 15

educate about photo sensitivity,stress the importance of avoiding tanning beds and exposure to sun let them know to take supplements like calcium and or magnesium supplements one hour before one hour after and take antibiotic exactly as ordered

front 16

client teaching with antibiotics

back 16

increase fluid to 3000ml unless contraindicated

report changes in hearing

report headache, dizziness,vertigo, educate about a superinfection

front 17

what should you make sure with cultures

back 17

cultures are drawn before antibiotic therapy

pay attention to signs and symptoms of superinfection

check med prior to giving

asses each class for specific interaction

front 18

what should you do before beginning drug therapy

back 18

check allergies,hepatic renal, cardiac function, and lab results, obtain patient health history, baseline labs,ekg,culture and sensitivity, Neuro and GI assesment, Asses for potential drug interactions

front 19

Vancomycin

back 19

Must monitor blood levels to ensure therapeutic levels and prevent toxicity make sure you give it slow

Treatment of choice for mrsa and other gram positive infections

oral vancomycin is used for cdiff

treatment of staphylococcal enterocolitis

front 20

quinupristin -Dalfopristin

back 20

used for bacteremia and infections caused by vre and complicated skin and skin structure by s pyrogen and Mrsa

front 21

Nitrofurantoin

back 21

used for uti example ecoli

use carefully with renal function is impaired

front 22

If you get something from hospital how long does it have to be untill its hospital aquired

back 22

48 hours

front 23

Metronidazole (flagl)

back 23

used for anaerobics organisms, intraabdominal and gynecologic infections, its also used as an atifungal and anti protozoa drugs

Do not drink alcohol

front 24

linezolid (zyox)

back 24

used to treat vref,Vre hospital aquired, and skin structure infections including those with mrsa, healthcare associated pneumonia

front 25

Cindamycin (cleocin)

back 25

bacterialcidal or bacteriostatic

gi tract adverse are common

may cause pseudomembranous colitis also known as antibiotic associated colitis, Clostridium difficile diarrhea or cdiff

front 26

Metronidazole (flagl)

back 26

be careful with alcohol

front 27

what are MIscellaneous Antibiotics

back 27

Clindamycin,(cleocin)

linezolid (Zyvox)

Metronidazole (flagl)

Vancomycin (Vancocin, Vancoled)

front 28

with quinolones what should you watch with oral anticoagulants

back 28

use with caution- decreased vitamin k absorption

front 29

enteral tube feeds with quinolones meds

back 29

can reduce absorptions

front 30

does dairy products reduce quinolone drugs

back 30

yes the reduce the effects

front 31

how long should you wait to give interacting drugs with quinolone drugs

back 31

you should wait at least an hour after you give quinolone drugs

front 32

oral quinolones

back 32

antacids, calcium,magnesium,iron zinc preparations,or sucralfate causes reduction in oral absorption

front 33

Quinolones adverse reactions

back 33

Ruptured tendons, tendonittis, fever, chills blurred vision tinnitus

front 34

trough for aminoglycosides

back 34

lowest drug level will. measure renal clearance of drug and avoid toxicity, usually obtained 1 hour before next dose is scheduled

front 35

Quinnlones:adverse reactions

back 35

cardiac Prolonged Qt intervals

front 36

Quinolones indications

back 36

grams-negative such as Psudomonas

urinarytract, bone and joint,gi, skin, and sexually transmitted infections,

Anthrax(ciprofloxacin)

front 37

quinolones medications

back 37

ciprofloacin (Cipro) Levofloxacin

front 38

quinolones(fluroquinolones)

back 38

Potent bacterialcidal broad spectrum antibiotics

front 39

peak for aminoglycosides

back 39

highest drug levels for once daily regimens usually 30 mins to 1.5 hours after dose

front 40

what should you do prior to giving Aminoglycosides

back 40

DO a peak and trough

front 41

Whats the adverse effects of Aminoglycosides

back 41

causes serious toxicities, Nephrotoxicity ,ototoxicity,