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INTRO TO GLOBAL HEALTH, midterm

front 1

health

back 1

state of complete physical, mental, and social well-being

not merely absence of disease or infirmity

front 2

public health

back 2

-disease prevention

-promoting physical health and efficiency

-prolonging life via organized community efforts

- developing social machinery to ensure standard of living adequate for maintenance of health

front 3

key aspects of public health

back 3

  1. disease prevention
  2. respect individual rights
  3. carry out community-based work (communities are actively participating)
  4. specific attention given to the disenfranchised
  5. perform data and evidence-based work
  6. wide range of disciplinary perspectives
  7. respect values, culture, and beliefs of others
  8. enhance physical and social environments

front 4

public health (in terms of differentiating it from clinical medicine)

back 4

- disease prevention, health promotion

- concerned with large populations (ie. public health system of the US)

- not narrow and directed; training of professionals is variable

front 5

clinical medicine

back 5

- focus is on individual people (obligated to the individual rather than a population) & their diagnosis, treatment, and care

- training is standardized

front 6

global health

back 6

- health problems, issues, concerns that transcend national boundaries

best addressed by cooperative action

- prevention and (ongoing) clinical care to solve these concerns

- focus on health needs of the impoverished

front 7

population-level screening for an infection or chronic disease is an example of a public health initiative

back 7

true

front 8

focus in field of public health

back 8

population-level health

front 9

focus in field of clinical medicine

back 9

individual health

front 10

focus for global health

back 10

health-related challenges that require international cooperation

- emphasis on needs of people experiencing poverty

front 11

clinical care is mainly outside the realm of global health

back 11

false

front 12

global health challenges

back 12

- lack of POC in leadership positions

- lack of women / gender diversity in leadership positions

- people in LMICs have insufficient control over global health agenda

front 13

why does textbook author prefer "impoverished countries" terminology?

back 13

demonstrates how these countries are poor as a product of their colonial legacy / exploitation rather than as a result of lack of hard work / merit

front 14

limitation of "impoverished countries" terminology

back 14

provides a single story

- what defines these areas is that they live in poverty and are victims

front 15

LMIC terminology

back 15

low and middle income countries

- general term that indicates the socioeconomic status of the countries that global health is interested in uplifting

(*not comprehensive*)

front 16

treaties versus declarations

back 16

treaties require countries to put the substance of the treaty into law within the country

declarations do not

front 17

The Universal Declaration of Human Rights was set forth in 1948 and is extremely well known, in part because it is legally-binding on all countries that have signed

back 17

false

front 18

The United States ratified the Convention on the Elimination of All Forms of Discrimination Against Women (CEDAW) after international pressure to do so

back 18

false

front 19

Around the world, the Convention on the Rights of the Child was ratified very quickly; currently, every nation except the United States has ratified this treaty

back 19

true

front 20

Declaration of Alma Ata

back 20

- recognized the need to address factors such as food, water, and trained attendants for childbirth

- emphasis on access to primary care

- advocated for international financing

*health as a human right*

front 21

Primary healthcare

back 21

essential healthcare that is evidence-based, accepted by the people it serves, and universally available to individuals and families in a given community

front 22

Right after the Declaration of Alma Ata, the concept of “sustainability” essentially forced the ideals of Alma Ata to be put on hold, and many LMICs were constrained to spending only about $5 per person per year on healthcare

back 22

true

front 23

Bamako Initiative

back 23

promoted the idea of user fees to generate the money needed to restock drugs in pharmacies and to pay healthcare workers

- drugs sold were marked up, profits used to restock drugs and pay health workers

front 24

The Bamako Initiative was relatively successful in many LMICs and has helped governments improve their healthcare financing and coverage

back 24

false

front 25

transatlantic slave trade

back 25

- took place for more than 400 years

- spanned three continents

- continues to have a major negative impact today on the health and well-being of many people in LMICs

front 26

resource extraction from formerly colonized countries continues to this day and plays a substantial causal role in the inability of many countries to fully offer universal healthcare

back 26

true

front 27

neoliberal economic theory

back 27

economies should be controlled exclusively by capitalist forces and the laws of supply and demand

front 28

ethical challenges in global health

back 28

- lack of POC/women/gender diversity in leadership

- LMICs have lack of control over global health agenda

- need for reparations / rectification of past injustices

- brain drain

- one-sided collaborations / current academic publishing system

front 29

focuses of our global health textbook

back 29

- activism around health as a human right

- infectious disease prevention= insufficient (ongoing care)

- prevention, treatment, and care

- actions in solidarity with people in impoverished countries

- understanding of the roots of inequities

front 30

public health versus global health (Mukherjee)

back 30

90% vaccination rate = huge PH success

global health -- who are those 10% who are not vaccinated and why?

front 31

how did AIDS epidemic reshape global health

back 31

focus was initially on prevention of disease

- now, has shifted toward combination of prevention, treatment, and care

front 32

International Bill of Human Rights (documents)

back 32

1) The Universal Declaration of Human Rights

2) The International Covenant on Economic, Social, and Cultural Rights (ICESCR)

front 33

UDHR, Universal Declaration of Human Rights

back 33

- government has obligation to guarantee rights of their citizens; respect, protect, and fulfill them along with educating society to demand them

coincided with Nuremberg trials

not legally binding, has moral weight

basis for developing several other national legal documents

front 34

World Bank

back 34

- international organization

- provides technical and financial assistance to developing countries to foster economic development and reduce poverty

front 35

Health-Related Clause of UDHR

back 35

1) everyone has right to standard of living adequate for health and well-being of himself and of his family

- food, clothing, housing, necessary social services, security in unemployment, etc.

2) motherhood / childhood are entitled to special care and assistance; all children, whether born in or out of wedlock, shall enjoy the same social protection

front 36

International Covenant on Civil and Political Rights (ICCPR)

back 36

- backed by US

- promoted rights associated with democratic society (free speech, assembly, voting, judiciary system)

1966

*focused on government repression of civil / political rights rather than lack of available healthcare/education as a violation of rights

front 37

International Covenant on Economic, Social, and Cultural Rights (ICESCR)

back 37

- backed by Soviet Union

- promoted socialist principles (right to employment, health, shelter, and education)

- includes right to health unlike ICCPR

1966

front 38

have the US or Russia ratified each other's covenants? (ICESCR & ICCPR)

back 38

no

front 39

Affordable Care Act (ACA)

back 39

freedom from health-related bankruptcy & impoverishment

front 40

Structural Adjustment Programs (SAPs)

back 40

loans in exchange for severe reductions to public expenditures, tax-breaks to businesses

- led to fewer civil servants on govt. payroll, little money for public infrastructure

- couldn't spend government money that would lead to a deficit, but that was the only way they could build middle class / protect citizens from destitution

- impoverished countries couldn't deliver on rights

front 41

Selective Primary Healthcare (SPHC)

back 41

- more realistic approach to healthcare for all

- simple interventions; using existing budgets for volunteer healthcare workers (rather than rebuilding infrastructure)

- low-cost tech to prevent disease

front 42

GOBI

back 42

- growth monitoring of children (nutritional education for mothers if children are underweight)

- ORS (oral rehydration solution) - preventing death from dehydration associated with diarrheal disease

- breastfeeding until age 6 months continuation until age 2 years

- immunization of children

front 43

Bamako Initiative drawbacks

back 43

- "user fees" as barrier to health for poor people, unequal access to care

- money collected through user fees -- not enough to adequately pay staff or stock pharmacies

front 44

Convention on the Elimination of All Forms of Discrimination Against Women (CEDAW)

back 44

- international bill of rights for women

front 45

Convention on the Rights of the Child

back 45

- most rapidly and broadly ratified human rights treaty in history

- rights to be free of discrimination, to health, and to education... states that children must have a say in decisions affecting their lives"

- only US hasn't ratified

front 46

ORS

back 46

oral rehydration solution

- given to individuals to prevent death from dehydration usually in case of diarrheal disease

front 47

immune deficiency

back 47

a state in which the body's normal defenses against infection or cancer are weakened

front 48

4-H club

back 48

- disparaging reference to homosexuals, Haitians, heroin users, and hemophiliacs

term emerged as AIDS claimed lives of more and more people -> led to widespread panic and stigma

synonymous with carrying the disease

front 49

members of all 4-H group were...

back 49

banned from giving blood, denied housing, employment

victims of violence and discrimination

front 50

cases suggested that AIDS pandemic likely began in

back 50

Africa, appeared a decade before it appeared in the US

idea of "Black African" disease origin led to further stigma along racial lines, promoted racist narratives of sexuality

front 51

HIV

back 51

human immunodeficiency virus

virus or infection that leads to AIDS, ie. weakens the immune system

front 52

AIDS

back 52

chronic immune system disease caused by immunodeficiency virus

front 53

UNAIDS (United Nation AIDS Program)

back 53

raise awareness and money for prevention efforts

help countries develop national plans to combat disease

front 54

three important factors in controlling AIDS

back 54

concept and infrastructure of primary healthcare -- people can access needed services

modern behavioral science -- public health information to craft prevention messages

emergence of a global conscience -- inspire international community to work together, finance response in coordination with WHO

front 55

transmission of AIDS

back 55

blood products, needles, and other instruments containing fluids

from mother to child through exchange of body fluids in utero, during birthing process & through breastfeeding

front 56

Special Programme on AIDS

back 56

tracked the spread of AIDS

front 57

PLWA

back 57

people living with AIDS

front 58

opportunistic infections

back 58

attack those with weakened immune systems

(AIDS leaves people susceptible to other infections)

front 59

_________ is the number-one cause of death for PLWA

back 59

tuberculosis (TB)

front 60

TASO

back 60

Ugandan-based AIDS fighting organization

Dr. Kaleeba and AIDS Support Organization

front 61

ACT UP

back 61

AIDS Coalition to Unleash Power

more militant group, direct action to call attention to AIDS and silence of policy makers

front 62

TAG

back 62

treatment action group

nonprofit that pushed for increased funding for pharmaceutical research for AIDS, particularly drug trials

front 63

About how many cases of dracunculiasis were recorded for the calendar year 2024?

back 63

15

front 64

Most high-income countries are predicted to accomplish the SDGs by the year originally set out for their accomplishment

back 64

false

front 65

In a TED talk about progress towards the SDGs, the speaker, Michael Green, made the very concerning point that progress has actually gone backwards for the goals related to water and sanitation

back 65

false

front 66

One feature of a communicable disease is that it is caused by an infectious agent

back 66

true

front 67

A chronic disease is one that lasts for a long time

back 67

true

front 68

An acute disease might have either infectious or non-infectious origins

back 68

true

front 69

A parasite is an organism that benefits from a host, that returns no benefit to the host, and that harms the host in some way

back 69

true

front 70

The Millennium Development Goals were in place from around 2000 to 2015, prior to the implementation of the SDGs

back 70

true

front 71

The following are likely to help control dracunculiasis...

back 71

ensure that all people can access safe drinking water

ensure that all people can access healthcare for about a month to remove the worm

front 72

All protozoa are parasitic

back 72

false

front 73

There is a medication that can be given to people with dracunculiasis to kill the worm; however, this medication is not available in most areas where dracunculiasis is present

back 73

false

front 74

During the MDG era, MDG 6 (infectious disease) experienced the best outcomes compared with the other MDGs; this is probably because of dedicated funding for that goal

back 74

true

front 75

vertical program

back 75

initiatives that are disease-specific and focus on the prevention of certain conditions rather than on bettering healthcare systems themselves (and health infrastructure).

front 76

diagonal program

back 76

leveraging of vertical funding to support her;thcare systems overall

more comprehensive than vertical programs

priority is to better healthcare infrastructure rather than target specific diseases

front 77

communicable diseases

(infectious diseases, transmissible diseases)

back 77

illnesses that result from infection, presence, and growth of pathogenic biologic agents

- in human or other animal host

front 78

pathogenic

back 78

capable of causing disease

front 79

infection is not interchangeable with...

back 79

communicable disease

front 80

infection

back 80

infection with biological agent has occurred, but may not be pathogenic or result in any type of disease

front 81

non-communicable diseases (NCDs)

back 81

diseases that are not spread through an infectious agent

front 82

chronic disease

back 82

disease that lasts a long time

front 83

acute disease

back 83

disease that develops rapidly, lasts for a short time, and has clear symptoms

may be caused by infectious agents

may also have non-infectious causes

front 84

injuries

back 84

includes a variety of ways that the human body can be harmed

front 85

total disease burden '90-'19 observations

back 85

communicable diseases have been decreasing overtime

communicable diseases still represent a large burden of the overall GBD

front 86

microbe

back 86

microscopic organism, not a technical term

- synthesize vitamins, prevent pathogenic organisms from invading, aid digestion, improve immune function

- objective: propagate

front 87

parasite

back 87

organism that benefits from a host

returns no benefit to the host

harms the host in some way

front 88

pathogen

back 88

any agent that can cause disease

front 89

zoonosis

back 89

disease of vertebrate animals that is transferred to humans

front 90

vector

back 90

organism that transmits a pathogen

front 91

host

back 91

the free food for a parasite

front 92

definitive host

back 92

host in which a parasite sexually reproduces / completes its lifecycle

front 93

intermediate host

back 93

the host in which a parasite develops but does not sexually reproduce (may asexually reproduce)

front 94

reservoir

back 94

any animal, person, plant, soil, substance, or combination of any of these in which the infectious agent normally lives

front 95

infectious agent...

back 95

must depend mainly on the reservoir for its existence

must be able to multiply in the reservoir

front 96

types of microbes

back 96

viruses, bacteria, protozoa, helminths

front 97

viruses

back 97

packaged DNA or RNA

protein coat

attack and invade host cells (think trojan horse)

do not propagate without a host cell

(examples: cold, HIV, measles, COVID)

front 98

bacteria

back 98

single-celled organisms visible with a microscope

one ring of DNA, sometimes plasmids

acquire genetic material from other organisms

(examples: strep throat, tuberculosis, leprosy)

front 99

protozoa

back 99

single-celled organisms

free-living or parasitic

generally are able to multiply in a human host

typically transmitted fecal-oral route

front 100

helminths

back 100

multicellular organisms

macroscopic

free-living or parasitic

front 101

helminths, three main groups

back 101

flatworms: flukes and tapeworms

thorny-headed worms: acanthocephalans

roundworms: nematodes

front 102

dracunculiasis

guinea worm disease

back 102

caused by the nematode dracunculus medinensis

one of the largest nematodes

infection is caused by drinking water contaminated with copepods that carry this type of larvae

front 103

life cycle

dracunculiasis

back 103

1) human drinks unfiltered water containing copepods

2) larvae released when copepods die

3) larvae penetrate host's stomach and intestinal wall; they grow and reproduce

4) fertilized female worm migrates to surface of the skin, causes blister, discharges larvae

5) larvae released into water from emerging female form

6) female worm begins to emerge from skin one year after infection

7) larvae consumed by copepod and grow into mature larvae in copepod

front 104

dracunculiasis epidemiology

back 104

only found in Chad and South Sudan

non-human reservoirs for infection do exist

no acquired immunity

only helminth transmitted ONLY via drinking water

front 105

dracunculiasis pathology

back 105

pain from emergence of adult worms

secondary bacterial infection

trapped adult worms

front 106

dracunculiasis diagnosis

back 106

characteristic blister

adult worm emerging from skin

front 107

dracunculiasis treatment

back 107

remove adult worm (5 ish cm a day)

control secondary bacterial infection

front 108

dracunculiasis infection risk factors

back 108

little or no access to safe drinking water

living in a community where other people have dracunculiasis

lack of access to healthcare facilities

lack of opportunity to filter unsafe water

lack of access to chemicals to kill copepods

living in a place where there is insufficient political will or ability to address dracunculiasis

front 109

dracunculiasis eradication efforts

back 109

began in 1980 at CDC in US

WHA called for full effort in '86

currently: concerns about dogs and other animals serving as reservoirs -- hope remains for eradication

front 110

eradication of disease

back 110

absence of X disease for 3 consecutive years in all countries

front 111

three categories Green (TEDTalk) grouped the 17 SDGs into?

back 111

  1. Nutrition and Basic Medical Care
  2. Personal Rights / Inclusiveness
  3. Water and Sanitation

front 112

need to measure progress / where we've seen progress so far (TEDTalk with Green)

back 112

not only focus on areas where we've been successful (nutrition and basic medical care), but can identify our challenge areas (personal rights and inclusiveness)

- seeing where there are opportunities to accelerate progress, negative trends to reverse

front 113

worrying trend (noticed by Green in TEDTalk)

back 113

declines in personal rights and inclusiveness in many wealthy countries (US and Brazil, countries moving backward in the past few years)

front 114

are most countries on track to meet the SDGs, as of 2018

back 114

no

- Denmark is the closest, most fall lower on the scale

not going to achieve this goal until 2094 overall

what we need is for the larger, wealthier countries to make more significant progress (have the resources to create change, need to be held accountable)

front 115

health system responsiveness

(ie. what does a health system need to be responsive?)

back 115

1) data

2) descriptive statistics

3) measurement tools and surveillance systems

front 116

descriptive statistics

back 116

mean, median, range, standard deviation of data set, etc.

- prevalence of conditions / risk factors

- incidence of new cases

- outcomes

front 117

The neonatal mortality rate is defined as the number of deaths of infants under 12 months per 1,000 live births in a given year.

back 117

false

front 118

The under-5 mortality rate is defined as the number of deaths of children under 5 per 1,000 live births, measured annually

back 118

true

front 119

One thing (among others) that DALYs can help measure is the disease burden associated with conditions that have low mortality but high morbidity

back 119

true

front 120

In our textbook, Dr. Mukherjee emphasizes that prevention of disease alone is insufficient without a commitment to treatment and ongoing care.

back 120

true

front 121

A neonate is a person under 28 days of age.

back 121

true

front 122

A cost-effectiveness approach in the context of global health states that interventions should cost no more than three times the per capita health costs, in order to be considered acceptable.

back 122

true

front 123

The following are important key criticisms of the “epidemiological transition model”...

back 123

- The disease burden is diverse in all countries, and the model fails to capture that reality

- Health systems in all countries are needed that can address a variety of health issues

front 124

Which of the following are common criticisms of the cost-effectiveness approach in global health...

back 124

- It doesn’t address other factors that negatively impact health

- The fixed costs in these models are planned for 5 to 10 years ahead of time, but this approach fails to account for changes in cost over time

- Out-of-pocket costs and other costs the patient experiences can still be high and aren’t captured by this approach

- It fails to address the actual burden of disease

front 125

Maternal mortality is measured as the deaths associated with pregnancy, labor, delivery, or within 42 days of childbirth

back 125

true

front 126

infant mortality rate

back 126

number of deaths of infants (<12 months) per 1,000 live births, measured annually

front 127

life expectancy at birth

back 127

average number of years a new baby can expect to live if current mortality trends continue

front 128

neonatal mortality rate

back 128

number of deaths of neonates (<28 days) per 1,000 live births, measured annually

front 129

under-5 mortality rate (child mortality rate)

back 129

number of deaths of children under 5 per 1,000 live births, measured annually

front 130

maternal mortality ratio

back 130

measure of the risk of death associated with childbirth

number of women who die each year as a result of pregnancy, labor, delivery, or within 42 days after delivery, per 100,000 women who deliver a live child

front 131

why is MMR measured per 100,000 but neonatal morality and under-5 mortality are measured per 1,000?

back 131

it's relatively rare compared to child mortality / neonatal mortality rates

produces a more meaningful, less fractional number

front 132

fertility rate

back 132

number of births per woman

front 133

morbidity

back 133

sickness

front 134

mortality

back 134

death

front 135

mortality rate

back 135

annual number of deaths per 100,000 population

front 136

disability

back 136

long-term or short-term reduction in functional capacity

front 137

prevalence

back 137

number of people with condition X at any given time

cross-sectional in nature

front 138

incidence rate

back 138

number of new cases over time per a given population that's at risk

front 139

disability-adjusted life year (DALY)

back 139

a measure of losses due to illness, disabilities, and premature death

- accounts for loss due to death and disability

- requires data about prevalence and incidence

Mortality + Morbidity

front 140

goal of health policy

back 140

avert DALYs in the most cost-effective way

front 141

risk factor

back 141

an entity (characteristic, environment, behavior, etc.) that is known to be associated with a health issue

front 142

health professionals seek to ______ risk factors

back 142

minimize

front 143

_______ is the lead risk factor for death and disability in high-income countries

back 143

smoking

front 144

malnutrition

back 144

a leading risk factor worldwide (too much, not enough, not the right kind of nutrition)

front 145

categories covered in global burden of disease study (GBD project)

back 145

- infections and perinatal and maternal conditions

- NCDs

- injuries and accidents

(grouped into 8 global regions - established market economies)

front 146

findings: global burden of disease study

back 146

- high premature mortality in impoverished regions

- lack of good data

- NCDs and injuries play a major role (infectious diseases also critical component)

- inequities among regions are enormous

- findings can be very different for mortality versus for DALYs

front 147

epidemiologic transition "ages"

back 147

1) age of pestilence and famine

2) age of receding pandemics

3) age of degenerative and manmade diseases

4) age of delayed chronic diseases

front 148

limitations of the epidemiologic transition model

back 148

1) diseases do not occur in a stepwise fashion (in contrast to what the model states)

2) disease burden is diverse in all countries

3) health systems in all countries are needed that can address a variety of health issues

4) treatment often is prevention, so healthcare systems need to be able to provide treatment

front 149

cost-effectiveness

back 149

1) formula proposed in '77 by Weinstein and Stason

2) for intervention to be cost-effective, its cost should be no more than 3x the per capita health costs

3) limited impoverished countries to interventions $5-15 per patient per year

front 150

limitations of cost-effectiveness

back 150

1) cheap interventions fail to address the actual burden of disease, out-of-pocket costs, & other costs the patient experiences (also - doesn't address other factors that negatively impact health)

2) fixed costs in cost-effectiveness models that are planned for 5-10 years out fail to account for cost changes

3) too little money allocated for health in impoverished countries; failing to provide healthcare is a moral issue

front 151

the epidemiologists's bathtub

back 151

prevalence = water in bathtub

water leaking out = death

recovery = water evaporating from tub

incidence = faucet putting water into the tub

front 152

burden of disease

back 152

quantity of diseases and conditions and their impact on a population

- assessing this = attempting to build systems of care to achieve targets in SDGs

front 153

Global Burden of Disease project ('90)

back 153

quantifies the impact of diseases worldwide on a regular basis

front 154

epidemiological transition

back 154

observed shift in the types of diseases that affect populations as economic conditions improve

- used disease burden to help countries of differing economic strata to assign health priorities

front 155

Disease Control Priorities (DCP) project

back 155

burden of disease in impoverished countries impede economic development -- need to address this

prioritize interventions with greatest impact on burden of disease impoverished communities

(uses cost-effectiveness analyses to help policymakers set priorities in national health systems)

front 156

health system responsiveness x burden of disease

back 156

the health of a population must be measured and understood if the health system is to appropriately respond

front 157

reasons to quantify the burden of disease

back 157

planning, policymaking, design of delivery systems, and program evaluation

front 158

disease

back 158

refers to conditions, illnesses, and injuries

front 159

burden

back 159

refers to the impact of disease on a population

front 160

disease surveillance

back 160

measurement of conditions

front 161

why insufficient data to estimate burden of disease early on?

back 161

1) never reach medical care (get sick and die at home)

2) facilities don't have adequate diagnostic capabilities (causes of illnesses remain unknown)

3) record keepers in short supply (insufficient data to estimate BOD)

front 162

sequelae

back 162

consequences of diseases

- GBD sought to characterize this

front 163

age of pestilence and famine

back 163

- high mortality rate in population

- caused by infectious diseases and starvation

low life expectancies

front 164

age of receding pandemics

back 164

reductions in mortality (esp. young children and infants)

life expectancy increase w/ improved access to food, clean water, and infrastructure

front 165

age of degenerative and manmade diseases

back 165

total fertility rate declines as infant mortality continues to fall

major causes of death = NCDs (cancer, diabetes)

front 166

age of delayed chronic diseases

back 166

reductions in mortality, old age, and primary prevention of chronic diseases (promotion of exercise and healthy diets)

front 167

three dependent inputs for prioritization (GBD project)

back 167

1) understanding types of diseases and overall burden within a country

2) design of health system to respond to need of population

3) ability of govt to set priorities, ability to use instruments at their disposal

*choosing interventions that could be supported within the confines of their health budgets*

front 168

There were around _______________ forced sterilizations of people in the US as part of a eugenics movement.

back 168

60,000

front 169

The Tuskegee Study focused on untreated syphilis among African American men; the study is considered highly unethical, in part because penicillin, a known treatment, was denied to participants for decades.

back 169

true

front 170

The US Government finally discovered the existence of the Tuskegee Study in 1972 and put an end to it

back 170

false

front 171

The Nuremberg Code was a result of the Nuremberg Doctors’ Trial, in which Nazi physicians were tried for war crimes and crimes against humanity.

back 171

true

front 172

The Nuremberg Code states that physicians doing research with human participants must ensure voluntary informed consent from participants (among other things).

back 172

true

front 173

The Nuremberg Code states that physicians doing research with human participants must ensure that the research is necessary in the sense of being a social good (among other things).

back 173

true

front 174

The Nuremberg Code states that physicians doing research with human participants must ensure that there are safeguards in place with respect to risk to human participants (among other things).

back 174

true

front 175

The Declaration of Helsinki came after the Nuremberg Code and supersedes it

back 175

true

front 176

The Declaration of Helsinki is a highly influential and extremely widely cited set of international research ethics guidelines.

back 176

true

front 177

Clinical research protocols must have social value and be scientifically valid when they involve human participants.

back 177

true

front 178

Clinical research protocols must fairly select study participants and researchers cannot enroll members of vulnerable populations when those same populations are unlikely to reap any benefits from the study.

back 178

true

front 179

For clinical trials, participants must always receive financial compensation (money).

back 179

false

front 180

The eugenics movement in the United States involved coercive policies (e.g., forced sterilizations, institutionalization) that targeted specific groups of people and forced them to have fewer children or no children at all.

back 180

true

front 181

How long did the Tuskegee study on untreated syphilis in African American men last?

back 181

40 years

front 182

The Belmont Report emphasizes the need for “justice” in research contexts, meaning that the benefits and burdens of research must be fairly distributed among populations.

back 182

true

front 183

The Belmont Report emphasizes the need for “beneficence” in research contexts, meaning that study participants must be financially compensated for study participation when studies contain at least a moderate level of risk.

back 183

false

front 184

The Belmont Report calls for respect for persons; this means that researchers must treat people as autonomous agents and protect people with diminished capacity to act as autonomous agents.

back 184

true

front 185

The Belmont Report strongly emphasizes the concept of “due process”.

back 185

false

front 186

In clinical research involving human study participants, benefits and risks need to be balanced at the level of the individual and at the level of society.

back 186

true

front 187

Key Principles of Belmont Report

back 187

1) respect for persons

people have autonomy, can make their own decisions

people w/ diminished capacity are also protected

2) beneficence

minimizing harms, maximizing possible benefits

3) justice

fairly distributing the benefits and burdens of research

front 188

how long did the Tuskegee syphilis study last? how long was it supposed to last?

back 188

supposed to last for: 6 months

lasted for: 40 years

front 189

two major ethical violations of Tuskegee

back 189

Lack of transparency in the study, human rights violations

individuals in the study given only placebos (mineral supplements and aspirin) and despite the fact that penicillin was recommended cure 15 years into the study

Provided participants with no effective care or treatment

PHS researchers convincing local physicians to not treat the patients even when treatment became available (men died, went blind, insane, etc)

front 190

Nuremberg Code

back 190

Following human rights abuses during WWII

Nazi doctors tried for war crimes and crimes against humanity

front 191

key concepts: Nuremberg Code

back 191

Voluntary, informed consent from participants (using that terminology rather than subjects) Necessary - research must be a social good (not just out of general curiosity)

Limits on risks to participants (higher risk levels for more fatal conditions, lower risks allowed for something like common cold)

Safeguards for patients with respect to risk (check ins, reporting adverse events)

front 192

Declaration of Helsinki

back 192

followed Nuremberg Code, superseded it (took the place of)

more specific, elaborates on points made in Nuremberg Code

Although not legally binding, was enshrined into local law

(has substantial moral power, revised frequently)

front 193

key focuses in D.O.H.

back 193

scientific validity

fairness

risks and benefits

placebos

consent

oversight and accountability

front 194

eugenics movement in the US

back 194

concluded that things like intelligence and ability are genetic

Humanity could be improved if more “fit” humans had more children

front 195

goals of eugenics movement

back 195

improving qualities of the family (natural, physical, mental, etc.)

targeted “unfit” individuals - people who would be inhibiting this goal

  • Forced them to have fewer children (ERO office), forced sterilizations
  • Genetics base for things like criminality, feeblemindedness

(social determinants of health not considered, biased data to support his theory)

front 196

how widespread was the eugenics movement in the US?

back 196

around 60,000 people in US were sterilized

30 states adopted laws allowing these forced sterilizations

front 197

simple explanation, Nuremberg Code

back 197

Nuremberg code was created as a result of the Nuremberg Trials that happened post WWII, where Nazi doctors were put on trial for their blatant human rights violations and crimes against humanity

The Nuremberg code was not legally binding but held moral value, and was made up of 10 ideas that established ethical principles for human experimentation

main topics covered: consent (voluntary), limiting risks, putting in place safeguards, and also necessity of the research

front 198

According to our textbook, the following are true about medical students in Uganda

back 198

They want more mentoring in their positions as clinical personnel, especially when they’re sent to rural areas.

They’re suing the Ugandan government to get access to better supervision/mentoring.

front 199

According to our textbook, the following are effective strategies to address brain drain

back 199

Provide acceptable mentorship and training opportunities

Ensure acceptable and attractive working conditions

Pay healthcare workers fairly

front 200

Programs by NGOs to train clinicians in LMICs are criticized for the following reasons

back 200

Providing short-term training that doesn't improve clinical outcomes

Pulling workers away from their posts

front 201

In many LMICs, there are generally a sufficient number of healthcare workers for the populations served, but they lack the training quality that’s needed to deliver good health outcomes.

back 201

false

front 202

The Sustainable Development Goals (SDGs) call for universal health coverage (i.e., everyone has access to healthcare in clinics/hospitals, etc.) by the year 2030.

back 202

true

front 203

In high-disease-burden settings, there are often enough community health workers, but there may not be a sufficient number of clinical specialists, such as surgeons.

back 203

false

front 204

The following are true of the healthcare workforce in many LMICs

back 204

The health workforce is generally structured and supervised hierarchically

Nurses and midwives are generally supervised by highly skilled specialists at district hospitals and tertiary care hospitals

Community health workers make up most of the health workforce and are supervised by nurses and midwives who work in health centers and district hospitals

front 205

Primary healthcare facilities are generally staffed by healthcare workers with professional skills and who have formal training, but who may not be doctors

back 205

true

front 206

District hospitals may play a role in population-level data analysis and also quality-improvement initiatives

back 206

true

front 207

District hospitals perform mostly routine tasks such as vaccinations and prenatal visits, but they might also play a role in surgery or emergency obstetric care

back 207

false

front 208

A skilled professional health worker is defined as any type of healthcare worker who is formally educated

back 208

true

front 209

A Public-Sector Spending Cap is the amount of available resources for public expenditures, set by local governments.

back 209

false

front 210

In impoverished countries, the cost of educating the healthcare workforce is mainly covered by private expenditure: individuals who wish to pursue training as doctors, nurses, etc. pay for their education through loans and out-of-pocket payment

back 210

false

front 211

The United States has noticeably higher healthcare expenditures per person than any other country in the world, according to figures from ourworldindata.org

back 211

true

front 212

One *general* trend seen in most countries is that with more money spent on health, health indicators such as life expectancy, child mortality, etc. tend to improve.

back 212

true

front 213

The price of various essential healthcare products such as soap and water disinfectant does not have a huge effect on whether people purchase them, mainly because people recognize their value and prioritize these essential items

back 213

false

front 214

Task shifting, although commonly practiced, often results in poorer health outcomes for the population served

back 214

false

front 215

public-sector spending cap

back 215

maximum amount of money that can be spent on public services and goods

set by world bank and IMF for countries that have SAPs

front 216

how is cost of education covered for healthcare workers in many impoverished countries?

back 216

governments provide education funding, free of charge and supported

SAPs restrict amount of money government can put toward services

cannot properly compensate their workers, don't have tools for proper training, cannot hire the graduates

front 217

why do some public-sector clinicians in impoverished countries work only half of a day in public clinics?

back 217

have private practices to help support their families, do private sector work

(not making enough money doing general work in the public sector)

using public resources to recruit affluent patients, looking for paid training progress

underpaid government health personnel

front 218

problems associated with NGO programs to train clinicians in impoverished countries

back 218

NGOs provide clinical training workshops

- short-term, not something that is long-lasting

- pull healthcare workers away from their posts, workers looking for more compensation

- training doesn't improve their performance because no one is overseeing them

front 219

what is brain drain?

back 219

draining of human capital, ie. trained health professionals, from impoverished countries to more affluent settings

front 220

why does brain drain occur?

back 220

job security, better working conditions, want to be compensated properly for their work

front 221

effective strategies to stop brain drain

back 221

wealthier countries providing financial support, help LMICs properly compensate their workers

decreasing active recruitment of health professionals from impoverished countries

improving working conditions, make them want to stay

front 222

why is brain drain a problem for impoverished countries?

back 222

drains them of human capital

worsening healthcare worker shortage

inhibiting development of healthcare infrastructure

front 223

mentoring for healthcare workers in high income countries

back 223

years of monitoring before they can see patients on their own

key element of clinical training

heavily supervised before allowed to practice independently

front 224

mentoring for healthcare workers in low-income countries

back 224

not enough specialists or ability to have junior clinicians work under supervision

training occurs through lectures rather than mentoring

limited amount of government funding - lack of oversight and mentoring for trainees

front 225

medical students in Uganda

back 225

Uganda minister of health changed internship policy

Mandatory two year service at government health facility

intention: using new grads to cover rural/underserved areas as payback for government funded education they received

Interns isolated in crumbling facilities, no mentors, meager stipends

Government needs to properly support trainees, provide work environment necessary to deliver care

1,000 suing government on grounds - entitled to postings with mentoring, payment, adequate training facilities

front 226

3 specific benefits expected if CHWs performed ivermectin distribution for onchocerciasis rather than community-selected volunteers

back 226

  • CHWs could ensure that people receive long-term care and could provide support throughout the process (ie. check-ups, answering questions)
  • CHWs are often connected with a health system, so in more serious cases they could provide referral for specialized treatment if ivermectin is insufficient (ie. surgery)
  • CHWs have intimate knowledge of the communities that they work within -- ie. they could individualize treatment (also - have community TRUST

front 227

One task that CHWs often accomplish is the delivery of preventive health services

back 227

true

front 228

One role of CHWs is to find people in the community who are sick and vulnerable and who are in need of connection to medical care

back 228

true

front 229

CHWs are able to deliver curative services and also to provide long-term care for chronic conditions.

back 229

true

front 230

CHWs are defined in our textbook as non-professionally educated workers who are trained to address health issues at the community level

back 230

true

front 231

CHWs are members of the communities they serve; they live and work near the patients, families, and communities they serve

back 231

true

front 232

Historically, CHWs were asked to be unpaid volunteers, but this is now changing to some extent

back 232

true

front 233

Around the 1960s, with many countries in Africa achieving liberation, CHWs were asked to volunteer and to perform key duties related to selective primary healthcare, such as GOBI initiatives.

back 233

true

front 234

Data show that most CHWs want to be paid fairly for their work rather than acting as volunteers

back 234

true

front 235

With proper training, CHWs are able to offer prenatal care and they can recognize obstetric emergencies.

back 235

true

front 236

CHWs can play many health-related roles, but the integrated community case management (iCCM) of childhood illnesses is reserved for physicians and nurse practitioners.

back 236

false

front 237

In many countries around the world, Vitamin A deficiency contributes to both maternal and child mortality.

back 237

true

front 238

Vitamin A supplementation can effectively address some aspects of child morbidity and mortality when given twice a year.

back 238

true

front 239

Blindness can occur if onchocerciasis remains untreated for a number of years.

back 239

true

front 240

With onchocerciasis, some individuals have itching and other skin-related symptoms, but these are relatively minor in comparison to symptoms in the eye

back 240

false

front 241

The adult worms that cause onchocerciasis may live for more than 10 years in a person in the absence of treatment.

back 241

true

front 242

CDTI (community-directed treatment with ivermectin) is the main strategy for onchocerciasis control in African settings right now

back 242

true

front 243

The regular distribution of a dewormer (called ivermectin) is widely considered essential for onchocerciasis control at this time

back 243

true

front 244

Multiple countries in the Americas have made great progress towards onchocerciasis elimination, but none have fully achieved elimination as of 2025.

back 244

false

front 245

Onchocerciasis transmission control can be partially achieved by controlling copepods in water sources

back 245

false

(this is guinea worm)

front 246

Mosquitoes are the main vectors that spread onchocerciasis.

back 246

false

black flies

front 247

filaria

back 247

tissue-dwelling worms that require an arthropod vector as an intermediate host

front 248

arthropod

back 248

invertebrate with jointed appendages that molts

front 249

what organism causes onchocerciasis?

back 249

Onchocerca volvulus

front 250

two key symptoms of onchocerciasis?

back 250

dead microfilariae cause severe skin inflammation due to release of wolbachia bacteria

- severe itching, abnormal skin pigmentation, lichenification (thickening, cracking of skin)

blindness if untreated

front 251

vector associated with onchocerciasis

back 251

black fly

front 252

current strategies to control onchocerciasis in endemic countries in Africa

back 252

African Program for Onchocerciasis Control (APOC)

established CDTI, community-directed treatment with ivermectin

promoted environmentally-sensitive vector control where possible

front 253

where are most cases of onchocerciasis?

back 253

Africa

99% of cases currently in 30 African countries

front 254

control strategies for onchocerciasis

back 254

vector control - dropping insecticide on water bodies to kill black fly larvae

ivermectin and doxycycline

front 255

addressing Vitamin A deficiency

back 255

supplements, need to find new mode of delivering this to people since polio vaccination scaled down

traditionally given during NIDs for polio

given 2x year

front 256

Prof. Dorothy Roberts and need to end race-based medicine

back 256

recently has been a push for 'evidence-based medicine' but makes it clear that racial biases still define modern healthcare, lead to misdiagnosis / improper medical treatment

- Black / Latino individuals given less pain medication than whites due to the misconception that they have been predisposed to drugs, have higher pain tolerance, etc.

- pay lip service to racial bias in medicine -- still pervasive, needs active acknowledgment to be fully addressed

front 257

The Essential Medicines List (EML) was developed by the WHO and serves as a guide for impoverished countries around drug procurement.

back 257

true

front 258

Pharmaceutical companies pay little attention to the Essential Medicines List (EML), which means that the EML has mostly failed to impact drug production

back 258

false

front 259

Generic drugs are needed worldwide; however, production of generic medicines that are off-patent remains low.

back 259

false

front 260

Generic drugs are almost universally good quality; there are very stringent regulations in place through multiple agencies to ensure this high quality.

back 260

false

front 261

Beginning with a conference in Bamako, Mali in the 1980s, there has been a push by key international organizations and decision-makers to have patients cover some or all of the cost of drugs.

back 261

true

front 262

Evidence shows that having consumers pay some or all of the cost of drugs reduces waste and allows healthcare systems to recoup essential costs

back 262

false

front 263

ART is not yet on the EML due to cost, but progress is being made in the fight to add it.

back 263

false

front 264

Currently, there are generic versions of ART, which has reduced the price of the drugs substantially

back 264

true

front 265

A high-level UN panel recommends that research and development (R&D) funding not be linked with drug prices for consumers and that instead, alternative methods of R&D funding be identified.

back 265

true

front 266

Public money, such as taxes, is often used to fund the preclinical drug discovery phase

back 266

true

front 267

There are some novel methods already in place to incentivize drug development for diseases that mainly affect people in LMICs; an example is the FDA Amendments Act of 2007.

back 267

true

front 268

Aid, novel purchasing plans, and philanthropy currently all play a role in bringing drugs to consumers in LMICs

back 268

true

front 269

_________________ is the most important producer of generic drugs worldwide

back 269

India

front 270

Expanded drug access worldwide relies heavily on the current and future availability of good quality generic drugs.

back 270

true

front 271

In the US, generic drugs are tested by the FDA for their chemical composition, so quality control is excellent.

back 271

false

front 272

Internationally, the WHO is generally responsible for checking the manufacturing quality and standards used by drug manufacturers; this is mainly done through a process called “prequalification”.

back 272

true

front 273

The “consumption method” of determining how much drug to stock involves using statistical methods to predict the number of cases of illness that will likely occur in the future and purchasing drugs according to those estimates.

back 273

false

this is the morbidity method

front 274

The “morbidity method” of stocking drugs relies heavily on data showing the number of drugs consumed in a previous period of time.

back 274

false

this is the consumption method

front 275

For all countries, about $13-25 per person per year needs to be spent to ensure that everyone can access essential medicines.

back 275

true

front 276

Priti Krishtel gave a TED talk about why drug prices are so high. One thing she talked about was the “patent wall”, which keeps drugs protected for 40+ years from competition by generics.

back 276

true

front 277

In her TED talk, Priti Krishtel gave multiple, very specific suggestions, including the following

back 277

Only give patents for products that substantially improve health prospects

Stop having the patent office in the US be funded by how many patents they grant

Ensure that the public in the US has the right to go to court over drug prices

front 278

AIDS activism and drug access / patents

back 278

led the way for the evolution of EML, fought for equal access to medication

getting ART on EML to increase production of generics

front 279

what is TRIPS? how does it relate to drug access?

back 279

governs the treaties patented and protected by the WTO (Trade-Related Aspects of Intellectual Property Rights)

countries claiming national emergencies to invoke TRIP flexibilities in dealing with AIDS (supporting generic version compulsory license to manufacture drug locally)

front 280

Updating and Disseminating the WHO's List of Essential Drugs: The Way Forward

back 280

2001 paper

argued for inclusions of newly-developed drugs even under patent when there were no generic options available

powerful pharmaceutical companies lobbied US government against it

- thought that this would cut their profits, that countries would use EML as a justification to invoke TRIP flexibilities, demand generic drug access

eventually allowed

front 281

in _______, ART was added to the EML

back 281

2002

front 282

5 key recommendations from the UN in 2016 that relate to access to drugs

back 282

- International agreements should improve innovation, not hinder

- delinking research and development from consumer prices

- Transparency – ie. marketing, distribution, pricing of health technologies = clear to public

- increased investment

- held accountable for ethical access to health technologies

front 283

5 key points for international collaboration to achieve the SDGs (2014, The Lancet)

back 283

  • Basket of essential medicines
  • Essential medicines = affordable
  • Quality and safety of said medicines
  • Correct use of medicines
  • Developing missing essential medicines

front 284

basket of essential medicines

back 284

a list of drugs selected to meet the priority health needs of a population

(need to be affordable, available, etc.)

front 285

what happens after governments procure drugs? where do they go and how?

back 285

- stored in a national drug store

- district-level pharmacies and hospitals request the medicines from the national drug store based on utilization over the prior month or quarter

- drugs distributed from district depots to health centers, also based on consumption over the prior month or quarter

front 286

problems with current drug procurement process

back 286

- LMIC budget insufficient to purchase needed drugs to meet disease burden

- lack of management -> leakage via theft / mismanagement of drugs

- poorly paid staff sell drugs and supplies to supplement salaries

- system and inputs needed for distribution are inadequate

front 287

consumption method

back 287

drug forecasting based on previous year consumption -> perpetual stock outs

front 288

demand signal

back 288

quantity or prior utilization of drugs

front 289

morbidity method

back 289

anticipated disease burden rather than forecasting based on previous year’s usage

- impoverished countries can't always use b/c their meager budgets cannot support what forecasted disease burden would be OR cannot determine full burden

(also - excess drugs that would go to waste?)

front 290

Soyapi Mumba spoke about innovations related to EMRs; which of the following are true, based on his talk

back 290

They needed to build their own cell towers to create a wireless network

They used old touchscreens from a failed US company

They used barcodes and scanners so that clinicians wouldn’t need to re-enter patient data at every visit

front 291

Paper booklets for health records can be lost by the patient if the patient is responsible for them. This is a substantial limitation to their use

back 291

true

front 292

Paper booklets for health records make it slow and difficult to accomplish meaningful data analysis at the population level. This is a substantial limitation to their use

back 292

true

front 293

Standardized health indicators are useful for program evaluation and to assess changes in health over time; however, a key limitation is that they are difficult to compare across different countries

back 293

false

front 294

To illustrate some of the key definitions in this chapter, Dr. Mukherjee provided an extensive example of malaria

back 294

false

front 295

One common problem with aggregated data is that it can be used to identify individuals, which violates some key ethical principles that relate to research with human study participants

back 295

false

front 296

What is the purpose of OpenMRS? (choose all that apply)

back 296

To give countries the ability to design electronic medical records and customize how those records are used

To offer software for electronic medical records at no cost to LMICs

front 297

Indicators are..

back 297

measurable, specific, observable, and useful for tracking progress / outcomes in healthcare systems

front 298

In the context of indicators used to evaluate healthcare systems, an "output" refers to tasks that have been undertaken or completed processes, provided these tasks and processes have resulted in positive outcomes.

back 298

false

front 299

Which of the following would be expected to have a positive impact in addressing tuberculosis? (choose all that apply)

back 299

An uninterrupted supply of good drugs

Data collection and data analysis

Political commitment

Access to diagnostic tools, like sputum-smear microscopy

Standardized DOTS

front 300

With respect to TB, a patient who has taken drug treatment for TB and who no longer shows TB bacteria in their sputum after the treatment course would generally be considered a "treatment success"

back 300

true

front 301

It’s very helpful to select health indicators that have existing data streams, rather than needing to create a new data stream.

back 301

true

front 302

What does DOTS stand for?

back 302

Directly, Observed, Treatment, and Short-Course

front 303

OpenMRS

(Open Medical Records System)

back 303

software platform that allows countries the ability to design and customize EMR

decreasing cost of EMR

training programers, offering free software

necessary b/c electronic data systems are integral to having strong healthcare system

front 304

Some vertical programs in global health have standard monitoring and evaluation frameworks, but others don’t.

back 304

true

front 305

Health “indicators” need to have clear definitions in order to be useful.

back 305

true

front 306

Health programs should develop specific targets to be achieved.

back 306

true

front 307

For monitoring plans, it’s useful to determine at the outset who will collect the data and
how frequently, but it’s not necessary to determine until later how the data will be
reported and analyzed.

back 307

false

front 308

A “logic model” is a way to show the connections between various steps in a program or intervention; it also serves as a framework that can be useful for analyzing the effectiveness of a program/intervention.

back 308

true

front 309

PDSA

back 309

Plan-Do-Study-Act

used to generate plans for improvement beginning with hypothesis for specific practices

(there would be more handwashing by healthcare professionals if ______ we took said action)

focuses on problems within a system / way it operates rather than blaming individuals for their mistakes

front 310

key principles of DOTS (scaling up TB treatment in LMICs)

back 310

  1. political commitment (long-term)
  2. sputum - smear microscopy access
  3. DOTS treatment
  4. Uninterrupted drug supply
  5. Data collection for program evaluation

front 311

case detection rate

back 311

New cases of TB / expected cases in location

front 312

DOTS coverage rate

back 312

PH facilities that can correctly offer DOTS / total # of PH

front 313

treatment success

back 313

patient who has taken drug treatment for TB

no longer shows TB bacteria in sputum

front 314

treatment success rate

back 314

# of patients who were successfully treated / # of patients diagnosed / started treatment (within set timeframe)

front 315

health equity, disaggregated data

back 315

aggregated data averaging and masking inequities

groups of people impacted very differently by policies and programs

front 316

genus and species: tuberculosis

back 316

mycobacterium tuberculosis

front 317

A _______ causes TB

back 317

bacterium

front 318

Approximately ______ of the world’s population is infected with the organism that causes TB.

back 318

24%

front 319

There is a vaccine currently in use for tuberculosis, but it doesn’t provide complete protection and there are some reasons that it would not be good to use in some settings.

back 319

true

front 320

The following are considered risk factors for active TB: (choose all that apply)

back 320

experiencing homelessness, having HIV, being undernourished, living in a household with others who have active TB, smoking, having alcohol use disorder

front 321

The following will probably help reduce the global tuberculosis burden

back 321

Poverty reduction strategies and socioeconomic development

Improved nutrition

Universal health insurance

front 322

The agent that causes TB need to be in the lungs for a person to be at risk of transmitting TB to others.

back 322

true

front 323

There can be a long lag between infection with M. tuberculosis and symptoms of disease.

back 323

true

front 324

People with M. tuberculosis have about a ______________ lifetime risk of developing TB from a latent infection.

back 324

5-10%

front 325

TB is preventable, according to the WHO.

back 325

true

front 326

Most cases of TB are treatable

back 326

true

front 327

The following can be symptoms of TB:

back 327

coughing up blood, night sweats, fever, otherwise unexplained weight loss

front 328

Men are more often affected by TB than women

back 328

true

front 329

Of the following options, which WHO region has the heaviest burden of TB?

back 329

WHO South-East Asia Region

front 330

We currently have a very promising vaccine candidate for tuberculosis, which is a major advancement with respect to TB control.

back 330

true

front 331

Indoor Residual Spraying with insecticide was a major malaria control strategy in the past but is not in widespread use as of the year 2025

back 331

false

front 332

Seasonal chemoprophylaxis for kids in the Sahel region can be an effective strategy to help control malaria.

back 332

true

front 333

Pregnant women should not take most types of antimalarial drugs due to potential for harm to the fetus. This is the major reason that pregnant women represent one of the high-risk groups for malaria mortality.

back 333

false

high mortality is due to how pregnancy alters the immune response

front 334

The two main factors determining malaria pathology in humans are anemia and the person’s immune response

back 334

true

front 335

What is an ITN (or IBN)?

back 335

A barrier that’s treated with chemicals to reduce the likelihood of insect bites

front 336

Which of the following are true of Anopheles gambiae (choose all that apply)

back 336

they breed easily

they have relatively long life spans

they prefer biting people more than animals

they are the main vector of concern for malaria

front 337

Malaria is considered the single most important parasitic disease of humans

back 337

true

front 338

By far, most cases of malaria are in countries in Africa; a smaller number of cases are in some countries in Southeast Asia, and there are still some cases in other locations, such as in Latin America.

back 338

true

front 339

Pregnant people and children younger than 5 years old in sub-Saharan Africa represent the major risk groups for malaria

back 339

true

front 340

Drug resistance by Plasmodium is concerned a pretty serious problem today.

back 340

true

front 341

Malaria episodes can include non-specific symptoms, so in places where malaria is endemic, it is important to get a diagnosis correct to perform the right course of treatment.

back 341

true

front 342

It’s common for children in malaria-endemic locations to be diagnosed incorrectly with malaria when in fact they have another condition, such as a serious bacterial infection.

back 342

true

front 343

The following are some of the characteristic features of the NTDs:

back 343

The tendency for people to have chronic symptoms

High possibility of disability and disfigurement

The tendency to cause stigmatized conditions

The tendency for them to be ancient conditions

front 344

Ascaris lumbricoides eggs can remain alive and infectious for years; they are resistant to chemicals like formalin and sulfuric acid.

back 344

true

front 345

Ascaris lumbricoides eggs can be killed by heat and sunlight.

back 345

true

front 346

Many NTDs are highly stigmatized; this represents a disproportionate burden for young men, compared with other demographic groups.

back 346

false

front 347

In the context of ascariasis and trichuriasis, MDA typically involves giving treatment to entire populations, regardless of an individual's infection status.

back 347

true

front 348

The word “neglected” in “NTDs” refers to the fact that many NTDs are neglected at the community level, country level, and global level.

back 348

true

front 349

People can contract whipworm or roundworm by ingesting eggs that were passed in the feces of other humans, especially when people who are infected practice open defecation

back 349

true

front 350

Adults of _______________________________________ live in the human gastrointestinal tract.

back 350

both Ascaris lumbricoides and Trichuris trichiura

front 351

Whipworm is diagnosed via stool sampling, while roundworm is mainly diagnosed through a rapid diagnostic test.

back 351

false

front 352

The following are risk factors for the STHs

back 352

poverty, poor housing structures, lack of access to sanitation facilities, lack of access to treatment within the community, being young

front 353

Ascaris worms have a long and complicated migration route through the body that includes the stomach, small intestine, heart, and lungs

back 353

true

front 354

Ascaris eggs are viable (able to infect people) for up to 1 year, but after about 1 year, they die and are no longer infectious.

back 354

false

front 355

Although people with Ascaris can be treated with deworming drugs, the drugs aren’t very effective, which contributes to the difficulty in controlling this NTD.

back 355

false

front 356

Nearly half of a billion people are infected with Trichuris.

back 356

true

front 357

Approximately how long do adult Trichuris live if a person doesn’t receive treatment?

back 357

a few years

front 358

Trichuris and Ascaris are often coendemic because they share similar risk factors.

back 358

true

front 359

People who have had Trichuris trichiura and Ascaris lumbricoides are very unlikely to be re-infected after treatment due to acquired immunity.

back 359

false

front 360

Both hand-washing and sanitation facilities are needed to help control Trichuris and Ascaris, among other strategies.

back 360

true