front 1 When it’s stated that once infected one can’t be ‘cured’ of HIV, this means that such an individual will... a. …eventually develop AIDS. b. …be permanently infected with HIV | back 1 ANSWER: B (be permanently infected with HIV) |
front 2 Treating the symptoms of ‘secondary’ opportunistic infections ‘Targeting’ HIV itself Can we inhibit transmission? | back 2 before 1987 could only target opportunistic infections could NOT target HIV at this point |
front 3 potential "targets" to block the HIV cellular replication cycle | back 3 human cells try to fight back (restriction factors)
unfortunately, HIV tries to prevent the restriction factors from working (viral antagonists) figure:
|
front 4 1 reason why cellular infection cycle began | back 4 we want drugs to inhibit individual steps 1st drug against HIV: blocks reverse trasncriptase (unique characteristic of the virus compared to our body) |
front 5 reverse transcriptase discovery: 1970s synthesizing DNA from an RNA template | back 5 published in nature june 27th 1970
|
front 6 AZT | back 6
|
front 7 AZT cont. | back 7
|
front 8 double blind study using AZT for HIV patients | back 8 6x per week 250 mg AZT or placebo 24 week period results:
|
front 9 AZT cont. | back 9 good:
bad:
|
front 10 AIDS in US since its recognition in 1981 | back 10 only in mid 90s was there a decrease in death rate |
front 11 1996: being diagnosed w/ AIDS no longer became death sentence | back 11
|
front 12 KNOW: 1996 considered | back 12 the MIRACLE YEAR |
front 13 WHO list of essential medicines | back 13 no data |
front 14 Eras + milestones of AIDS/HIV in the USA | back 14 1) 1981-1983 2) 1983-1987 3) 1987 – could slow down replication 4) 1996 - miracle year 5) Current ( still no cure or vaccine ) in last 28 years, progress has been made, but no cure or vaccines we HAVE figured out how to prevent transmission |