front 1 What level is diagnostic for CF? | back 1 >/= 60 mol/L |
front 2 Unique Non-classic symptoms of CF | back 2 1. Chronic bacterial infection of LATER onset 2. Adequate pancreatic function/pancreatitis 3. Sweat Cl 60-90 mol/liter; sometimes normal |
front 3 Unique Classic symptoms of CF | back 3 1. Severe chronic bacterial infection of airways 2. Severe hepatobiliary disease 3. Pancreatic exocrine insufficiency 4. Meconium lieus at birth 5. Sweat Cl 90-110 |
front 4 Kalydeco | back 4 Ivacaftor; Do not use as mono therapy for homozygous F508delta |
front 5 Orkambi | back 5 Lumacaftor/ivacaftor |
front 6 Symdeka | back 6 Tezacaftor/ivacaftor |
front 7 Trikafta | back 7 Elexacaftor/tezacaftor/ivacaftor |
front 8 Which agent is used in Delta F508 heterozygous greater than 4 months of age | back 8 Kalydeco (Ivacaftor) |
front 9 Which two agents can be used in Delta F508 homozygotes between 2 and 5 | back 9 Trikafta Orkambi |
front 10 Which agent is used in Delta F508 heterozygous greater than 2 years of age | back 10 Trikafta |
front 11 Which agent is used in Delta F508 heterozygous greater than 6 years of age | back 11 Trikafta Symdeka |