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23 notecards = 6 pages (4 cards per page)

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Antidepressants: SSRIs

front 1

Selective Serotonin Reuptake Inhibitors (SSRIs)

back 1

no data

front 2

Mechanism of Action: SSRIs

back 2

SSRIs increase serotonin (5-HT) by inhibiting its reuptake (reabsorption) in the neuronal synapse.

NOTE: SSRIs also weakly affect (Norepinephrine) NE and (Dopamine) DA.

front 3

Sertraline

back 3

Zoloft

front 4

Escitalopram

back 4

Lexapro

front 5

Citalopram

back 5

Celexa

front 6

Fluoxetine

back 6

  • Prozac
  • Sarafem

front 7

Paroxetine

back 7

  1. Paxil
  2. Pexeva
  3. Brisdelle

front 8

Fluvoxamine IR/ER

back 8

N/A

front 9

What are the 6 SSRIs?

back 9

  1. Sertraline (Zoloft)
  2. Citalopram (Celexa)
  3. Escitalopram (Lexapro)
  4. Fluoxetine (Prozac)
  5. Paroxetine (Paxil)
  6. Fluvoxamine

front 10

Most Common Adverse Effects of SSRIs

back 10

  • N/V/D
  • HA
  • Reduced Libido/Abnormal Ejaculation
  • Tremor
  • Somnolence
  • Insomnia
  • Dizziness
  • Fatigue

front 11

FDA Indications: Sertraline (Zoloft)

back 11

  1. Major Depressive Disorder
  2. Panic Disorder
  3. OCD
  4. PTSD
  5. Social Phobia
  6. Premenstrual Dysphoric Disorder

front 12

FDA Indications: Escitalopram (Lexapro)

back 12

1. Generalized Anxiety Disorder

2. Major Depressive Disorder

front 13

FDA Indications: Fluoxetine (Prozac)

back 13

  1. Bulimia Nervosa
  2. Panic Disorder
  3. OCD
  4. Social Phobia
  5. Premenstrual Dysphoric Disorder

front 14

FDA Indications: Citalopram (Celexa)

back 14

  • Depression

front 15

*RX PREP BOOK STATED:*

ALL SSRIs are approved for depression and a variety of anxiety disorders!

back 15

no data

front 16

Which SSRI is Pregnancy Category D?

back 16

Paroxetine (Paxil)

front 17

Patient Counseling Tips

back 17

no data

front 18

Patients taking ________ should be advised that it is the most activating SSRI and can keep you awake.

back 18

Fluoxetine (Prozac)

front 19

When should Fluoxetine (Prozac) be taken?

back 19

Fluoxetine (Prozac) should be taken in the morning (QAM)

front 20

Patients taking SSRIs should be advised to avoid starting OTC drugs without notifying their doctor due to possible drug interactions resulting in ___________ syndrome.

back 20

Serotonin

front 21

Serotonin Syndrome is characterized by the following symptoms:

back 21

  1. Tachycardia (racing heartbeat)
  2. Hallucinations
  3. Feeling very agitated
  4. Severe N/D
  5. Severe HA
  6. Severe dizziness

front 22

Patients should be advised that SSRIs can cause __________ __________.

back 22

Sexual Difficulties

NOTE: Patients should contact their doctor to consider being switched to another agent that does not have these effects.

front 23

Patients should be advised that SSRIs cannot be abruptly discontinued. Patient MUST be _________ off.

back 23

Tapered