Antipsychotic & Lithium (Powerpoint)

Helpfulness: 0
Set Details Share
created 2 years ago by mkeobounna
8 views
Chapter 29
updated 2 years ago by mkeobounna
Subjects:
pharmacology
show moreless
Page to share:
Embed this setcancel
COPY
code changes based on your size selection
Size:
X
Show:
1

What are the Positive Symptoms of Schizophrenia?

  1. Hallucinations
  2. Delusions
  3. Bizarre Behavior
  4. Positive formal thought disorder
2

What are the Negative Symptoms of Schizophrenia?

  1. Alogia
  2. Affective Flattening
  3. Avolition-apathy
  4. Anhedonia-asociality
  5. Attention impairment
3

Alogia

The inability to speak

4

Affective Flattening

Restricted range of expressed emotions

5

Avolition-apathy

Lack of energy and sn inability to persist in routine activities

6

Anhedonia

Lack of feeling pleasure or reward

7

Hallucinations

Sensory experiences that occur of environmental stimulation.

Commonly auditory

8

Cognitive Schizophrenia Symptoms:

  1. Attention
  2. Memory
  3. Language
  4. Motor Skills
  5. Executive functioning
9

What is the mechanism of Positive Schizophrenia Symptoms?

Overactivity of dopamine neurons in the Mesolimbic pathway

10

What is the mechanism of Negative Schizophrenia Symptoms?

Underactivity of dopamine neurons in the MesoCortical pathway.

11

Glutamate Theory of Positive & Negative side effects

PCP "angel dust" (amphetamine) blocks Glutamate Receptor (NMDA receptor), causing overactivity of Mesolimbic pathway and underactivity of mesocortical pathway

12

What are the two subtypes of 5-HT Receptor? What Schizophrenic symptom do they have an effect on?

  1. 5-HT2A
  2. 5-HT2C

Hallucinatory effect

13

What class of drug is 5-HT2A receptor blockers?

What type of agonist? Example?

Atypical Antipsychotic Drugs

Inverse Agonist

Ex. Clozapine

14

Stimulation of 5-HT2C receptors leads to inhibition of what? What type of agonist?

Inhibition of cortical & limbic dopamine release.

Inverse agonist

15

What does 5-HT2C drug stimulators do?

Inhibit Dopamine release

16

What receptors do Atypical Antipsychotic Drugs block?

Loosely block D2 Receptors

Block Serotonin 5-HT Receptors

17

What side effect Typical Antipsychotic drugs tend to have?

Extrapyramidal side effects (REVERSIBLE)

18

Atypical Antipsychotic drugs do not induce what side effect?

Extrapyramidal Dysfunction

19

What does blocking 5-HT receptors do?

Decreases Negative symptoms and EPS

Serotonin blocks dopamine release

low serotonin = high dopamine

20

Why do typical drugs have an EPS but atypical drugs do not have an EPS?

Typical antipsychotics bind to D2 receptors more strongly. Whereas Atypical antipsychotics loosely bind to D2 receptors.

21

What Atypical drug is most effective in reducing EPS, that also reduces Negative symptoms?

Clozapine

22

Clozapine greatly reduced what level in the body that would cause them to be immunocompromised?

What side effect does it have that would cause pt's not want to take the drug anymore?

WBC

Weight gain

23

What drug increases prolactin levels, therefore, should not be given to pt's with Breast Cancer?

Risperidone

24

What are the different classifications of mood stabilizing drugs?

  1. Lithium Carbonate
  2. Antiepileptic (Seizure)
  3. Atypical Antipsychotic
  4. Benzodiazepines
25

What is the Mechanism of Lithium?

Reduces ALL 2nd Messengers:

  1. PIP2
  2. IP3
  3. DAG

By inhibiting Inisotol