Clinical Laboratory Chemistry: Chapter 22 Toxicology Flashcards
Salicylate intoxication can result ina metabolic acidosis due to the accumulation of which of the following acids?
A. salicylic acid
B. lactic acid
C. pyruvic acid
D. all of the above
all of the above
Most photmetric methods used to measure salicylate concentration in serum are based on which of the following methods?
Which of the following enzymes is used to provide a specific measurement of ethanol in serum?
A. alcohol dehydrongenase
C. alcohol dehydratase
D. alcohol synthetase
Carboxyhemoglobin can be measured by what technique?
Ethylene glyco metabolizes to which of the following acids?
A. acetic acid
B. oxalic acid
C. gamma-aminobutyric acid
D. formic acid
Which of the following instruments can be used to measure toxic substances in blood or urine?
D. electrophoresis system
Lead inhibits which of the following enzymes?
A. pseudocholinesterase and gamma-glutamylhydroxylase
B. 5'-nucleotidase and ferricochelatase
C. aminolevulinic acid dehydrase and ferrochetlatase
D. delta aminolevulinic acid dehyroxylase and ferrochelatase
aminolevulinic acid dehydrase and ferrochelatase
Which of the following classes of compounds may be included in drugs-of-abuse screening?
Which of the following is an example of a definitive or reference method that is suitable for confirming positive drugs-of-abuse testing?
What does GCMS stand for?`
Gas Chromotography Mass Spectrometry
What does HPLC stand for?
High Performance Liquid Chromotography
What two immunoassays are used to measure toxic substances?
FPIA (Fluorescence Polarization Immunoassay) and EMIT (Enzyme Multiple Immunoassay)
The COhgb is measured by:
Mary-Janes Super-Clean 13, Klear, Whizzies, UrinAid, Urine Luck, Stealth, and Instant Clean ADD-IT-IVE are used for what purpose?
To intentionally attempt to thwart drug detection; attempt to pass a drug test; clean your pee
Which lab test can be used to detect whether urine has been tampered with?
pH, Creantinine, Specific Gravity
What type of anemia can lead poisoning cause?
Hypochromic, Microcytic Hemolytic Anemia
What is an example of a barbituate?
Cocaine is a upper or a downer?
What are examples of opiates?
Oxcodone, Heroin, Vicodin
What is Angel Dust?
Meth, Ecstacy, and Ritalin are examples of what class of drugs?
Xanax, valium, and Klonopin are all examples of what drug class?
What is the matabolite of ethanol?
What are the metaboloties of Methanol? ________ --> ______
Formaldehyde, Formic Acid
What are the (4) metabolities of Ethylene Glycol?
Glycoaldehyde, Glycolic Acid, Glyoxylic Acid, Oxalic Acid
What is the metabolite of isopropyl alcohol?
Which compound leads to oxidative phosphorylation, which increased oxygen consumption and increased CO2 production. (Hyperventilation and Respiratory Alkalosis)
Pyruvic Acid, Lactic Acid, and Actetoacetic Acid can cause ________ __________.
If large overdose occurs, respiratory __________ can occur and lead to respiratory acidosis
Gradual escalation of needed dose of drug to produce required effect is called:
Class of drugs that relieve pain without causing loss of consiousness
Refers to drugs that are prescribed to relieve symptoms of anxiety
Synthetic morphine-like drugs with non-peptide structure
The toxic effect of acetaminophen overdose is:
Hepatocytic Necrosis (Liver Death)
Which compound relaxes the smooth muscles of the broncial passages?