Clinical Laboratory Chemistry: Chapter 22 Toxicology Flashcards


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1

Salicylate intoxication can result ina metabolic acidosis due to the accumulation of which of the following acids?

A. salicylic acid
B. lactic acid
C. pyruvic acid
D. all of the above

all of the above

2

Most photmetric methods used to measure salicylate concentration in serum are based on which of the following methods?
A. Rosalki
B. Trinder
C. Henry
D. Karmen

Trinder

3

Which of the following enzymes is used to provide a specific measurement of ethanol in serum?

A. alcohol dehydrongenase
B. pseudocholinesterase
C. alcohol dehydratase
D. alcohol synthetase

alcohol dehydrongenase

4

Carboxyhemoglobin can be measured by what technique?

cooximetry

5

Ethylene glyco metabolizes to which of the following acids?
A. acetic acid
B. oxalic acid
C. gamma-aminobutyric acid
D. formic acid

oxalic acid

6

Which of the following instruments can be used to measure toxic substances in blood or urine?
A. osmometer
B. refractometer
C. GCMS
D. electrophoresis system

GCMS

7

Lead inhibits which of the following enzymes?
A. pseudocholinesterase and gamma-glutamylhydroxylase
B. 5'-nucleotidase and ferricochelatase
C. aminolevulinic acid dehydrase and ferrochetlatase
D. delta aminolevulinic acid dehyroxylase and ferrochelatase

aminolevulinic acid dehydrase and ferrochelatase

8

Which of the following classes of compounds may be included in drugs-of-abuse screening?
A. Barbiturates
B. Alcohols
C. Sterols
D. Prostaglandins

Barbiturates

9

Which of the following is an example of a definitive or reference method that is suitable for confirming positive drugs-of-abuse testing?
A. Immunoassays
B. HPLC
C. GCMS
D. Electrophoresis

GCMS

10

What does GCMS stand for?`

Gas Chromotography Mass Spectrometry

11

What does HPLC stand for?

High Performance Liquid Chromotography

12

What two immunoassays are used to measure toxic substances?

FPIA (Fluorescence Polarization Immunoassay) and EMIT (Enzyme Multiple Immunoassay)

13

The COhgb is measured by:

Cooximeter

14

Mary-Janes Super-Clean 13, Klear, Whizzies, UrinAid, Urine Luck, Stealth, and Instant Clean ADD-IT-IVE are used for what purpose?

To intentionally attempt to thwart drug detection; attempt to pass a drug test; clean your pee

15

Which lab test can be used to detect whether urine has been tampered with?

pH, Creantinine, Specific Gravity

16

What type of anemia can lead poisoning cause?

Hypochromic, Microcytic Hemolytic Anemia

17

What is an example of a barbituate?

Phenylbarbital

18

Cocaine is a upper or a downer?

Upper

19

What are examples of opiates?

Oxcodone, Heroin, Vicodin

20

What is Angel Dust?

PCP (Phencyclidine)

21

Meth, Ecstacy, and Ritalin are examples of what class of drugs?

Amphetamines

22

Xanax, valium, and Klonopin are all examples of what drug class?

Benzodiazepines

23

What is the matabolite of ethanol?

Acetalaldehyde

24

What are the metaboloties of Methanol? ________ --> ______

Formaldehyde, Formic Acid

25

What are the (4) metabolities of Ethylene Glycol?

Glycoaldehyde, Glycolic Acid, Glyoxylic Acid, Oxalic Acid

26

What is the metabolite of isopropyl alcohol?

Acetone (ketone)

27

Which compound leads to oxidative phosphorylation, which increased oxygen consumption and increased CO2 production. (Hyperventilation and Respiratory Alkalosis)

Salicylate

28

Pyruvic Acid, Lactic Acid, and Actetoacetic Acid can cause ________ __________.

Metabolic acidosis

29

If large overdose occurs, respiratory __________ can occur and lead to respiratory acidosis

Depression

30

Gradual escalation of needed dose of drug to produce required effect is called:

Tolerance

31

Class of drugs that relieve pain without causing loss of consiousness

Analgesic

32

Refers to drugs that are prescribed to relieve symptoms of anxiety

Anxiolytic

33

Synthetic morphine-like drugs with non-peptide structure

Opiates

34

The toxic effect of acetaminophen overdose is:

Hepatocytic Necrosis (Liver Death)

35

Which compound relaxes the smooth muscles of the broncial passages?

Theophylline