Basic Principles of Drug Actions and Drug Interactions

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created 2 years ago by mmiyakooo
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1

two drugs w/ similar actions are taken for increased effect

Addictive effect

2

Hydrocodone + acetaminophen = added analgesic effect

Addictive effect

3

the combined effect of two drugs is greater than the sum of the effect of each drug given together

Synergistic effect

4

Aspirin + codeine = much greater analgesic effect

Synergistic effect

5

one drug interferes with the action of another

Antagonistic effect

6

Tetracycline + antacids = decrease absorption of the tetracycline

Antagonistic effect

7

the displacement of the first drug from protein-binding sites by a second drug increase the activity of the first drug bc more unbound drug is available

Displacement

8

Warfarin + valproic acid = increased anticoagulant effect

Displacement

9

the first drug inhibits the metabolism or excretion of the second drug, thereby causing increased activity of the second drug

Interference

10

Probenecid + ampicillin = prolonged antibacterial activity of ampicillin bc probenecid blocks the renal excretion of ampicillin

Interference

11

the first drug is chemically incompatible w/ the second drug; thereby causing deterioration when the drugs are mixed in the same syringe or solution or are administered together at the same site; signs include haziness, formation of a precipitate, or a change in color of the solution when drugs are mixed

Incompatibility

12

ampicillin + gentamicin = ampicillin inactivates gentamicin

incompatibility