Organic Chemistry Review
Polar protic solvents contain these bonds:
N-H or O-H
Charged nucleophiles/bases favor these reactions:
SN2 or E2
Neutral nucleophiles favor these reactions:
SN1 or E1
Primary alkyl halides favor these reactions:
SN2 or E2
Tertiary alkyl halides favor these reactions:
SN1 or E1
Polar aprotic solvents favor _______ reactions over ________ reactions.
Polar protic solvents favor _______ reactions over ________ reactions.
DMF is a polar ________ solvent.
Acetone is a polar _______ solvent.
Ethanol is a polar ________ solvent.
OCCH3 is an example of a _______ base.
Methyl compounds can ONLY undergo _____ reactions.
Primary substrates always undergo SN2 reactions, unless a ________________ is present. Its primary products then undergo ______ reactions.
strong bulky base; E2
Strong bases favor _____ reactions.
Inversion occurs in _____ reactions.
Nucleophiles attack from either side in _____ reactions.
Favors most substituted
Order of nucleophilic strength in polar protic solvents:
F > Cl > Br > I
Order of nucleophilic strength in polar aprotic solvents:
I > Br > Cl > F
The stronger the nucleophile, the ______ the leaving group.
The more sterically hindered the solvent, the _____ likely elimination becomes.
Low temperatures favor ________________.
High temperatures favor _________________.
OCCH3 (tert-butoxide) ALWAYS favors ___.
In O3 reactions, alkenes become _________.
In O3 reactions, alkynes become _________.
In addition reactions, the presence of OH indicates the product will be in ______ configuration.
In addition reactions, the absence of OH indicates the product will be in _______ configuration.
OTs is a ______ leaving group.
If a reaction has quinoline, odds are it is _______________.
Lindlair's catalyst reactions form _____ _________.
Na, NH3 reactions form products in the ______ configuration.
If Pd is present, the product will have ______ configuration.
Tautomerization forms either ________ or _________.
aldehyes or ketones
In tautomerization, enols must react to form _________.
The rearrangement of bonds in a compound usually by moving a H and forming a double bond.
R-OH-PBr2 is a ______ leaving group.