Pathology (not on any WS)

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created 3 years ago by sh7606
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1

Pathology

Nerve injury
limited re-growth using glial cells
parallel nerves help some
Synaptic Transmission Disorders
Too much or too little NT release
EX: Parkinson's disease, alzheimers, epilepsy
Drugs in ECF
Disorders of ion balance

2

Alzheimer's

named after Dr. Alois Alzheimer
German neurologist
in 1906, examined a woman's brain who was dead of dementia
saw plaques and tangles

3

Tangles

Alzheimer's

form inside dying cells
twisted fibers of tau (a protein) that disintegrate the transport system so nutrients etc can no longer move through cells

4

Plaques

Alzheimer's

are abnormal clusters of chemically "sticky" proteins called beta-amyloid that build up between nerve cells

5

Alzheimer's Treatment

Increase acetylcholine by cholinesterase inhibitor
can delay, but not prevent

6

Parkinson's Disease

2nd most common neuro disease
Substantia nigra- nerve cells in midbrain
Parkinson's is when these die, or are impaired
They are dopamine-secreting cells

When 80% of dopamine cells depleated, PD symptoms show
tremors in hands

7

Parkinson's Treatment

Supplement dopamine with Levodopa (L-DOPA)
it is modified by brain enzymes to produce dopamine

also use things that breakdown catecholamines

Carbidopa (LODOSYN)- prevents breakdown of L-DOPA