Chapter 25

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1

Retroviruses contain a single

positive stranded RNA with the virus's genetic information and a special enzyme called reverse transcriptase in their core

2

Reverse transcriptase enables the virus

to convert viral RNA into DNA

this reverses the normal process of transcription in which DNA is converted to RNA thus, the term retrovirus

3

the HIV-1 viron consists of

Knoblike structures composed of a protein called gp120 which is anchored to another protein calle dgp41

4

each knob includes three sets of these

protein molecules

5

THE core virus includes a protein called

p25

or

p24

6

after human exposure, these and other viral components may

induce an antibody response important in serodiagnosis

7

The pol gene encodes for

reverse transcriptase

endonuclease

protease activities

8

The infectious process begins when gp120 protein on the viral envelope binds to the protein

receptor called CD4, located onto surface of a target cell

9

hiv-1has marked preference of the

CD4+ subset of T lymphocytes

10

Immunologic activation of CD4+ cells

latently infected with HIV induces the production of multiple viral particles, leading to cell death.

11

the extensive destruction of cells leads to the gradual depletion of

CD4+ lymphocytes

12

Progressive defects in the immune system include a

severe B cell failure

defects in monocytes function

defects in granulocyte function

13

line immunoassay LIA is a

popular confirmatory tests

14

LIA incorporates separate

HIV antigens on nitrocellulose strips so that each reaction can be visualized separately. L

15

LIA offers better quality control and better reproducibility tehn

western blot

16

the antigens are synthetic and recombinat which

decreases the background form nonspecific host proteins

this decreases the number of indeterminate LIA results in uninfected patients

17

POL

produces DNA POLYMERASE PRODUCES ENDONUCLEASE

18

GAG

codes for p24 and for proteins such as p17, p9, p7

19

env

CODES FOR two glycopretins

gp41

gp120