Chapter 24

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1

Acquired rubella is also known as german measles

3 day measles

2

Because the virus is endemic to human

the disease is highly contagious and transmitted thru respiratory secretion

3

contracting the infection and vaccination against rubella are the only routes to developing

immunity

4

in evolution of the immune status of patients IgG antibodies that are present in a dilution of

1:8 or greater indicates past infection with rubella virus and clinical protection against future rubella infection

5

The clinical significance of lower levels is not currently

known

6

Titers of 1:16, 1:64, 1:152 or higher may be found in

acute and past infections

7

however diagnosis of acute infection require IgM antibody T

titer on the same specimen or paired specimen comparion

8

IgM also appears for

transit period after vaccination

9

Hemagglutination inhibition antibody testing

has been the most frequently used method of screening for the presence of rubella antibodies

10

recently HAI test has been replaced by more convenient assays as the screening method of choice for

determination of rubella immune IgG status

11

in some patients such as pregnant women it also may be necessary to

determine whether a recent infection has occurred.

12

Serodiagnosis may not be differentiate between

primary infection and reinfection

13

an IgM specific procedure must

be used.

14

latex particles are sensitized with solubilized rubella virus antigens from the disrupted irons judged to be

inactivated.

15

When the latex reagent is missed with serum containing rubella antibodies on a dark surface, the antigen-antibody complex will form

visible clumps

16

in the absence of antibody or if concentration is insufficient to react, the latex particles will remain

smooth and evenly dispersed.

17

if a qualitative procedures is performed the presence of rubella antibodies is an ideation of

previous infection and presumptive immunity can be used to evaluate the immune status of that individual with regard to resistance or susceptibility to primary rubella infection