Chapter 22

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1

Infectious mononucleosis caused by

EBV is usually acute, benign, self-limiting lymphoproliferative condition

2

EBV is also the cause of

Burritos lymphoma a malignant tumor of the lymphoid tissues accourring mainly in African children

nasopharyngeal carcinoma

neoplasm of the thymus

parotid gland

supraglottic lynx

3

EBV is an important factor in the development of

nasopharyngeal carcinoma epithelial cancer

Although nasopharyngeal carcinoma is rare in the North American and European whites, it is among the most common cancers in sour then china and parts of southeast asai

4

Genetics and environmental factors

appear to contribute to the elevated risk of nasopharyngeal carcinoma among the chines

5

EBV is widely disseminated and is the most

ubiquitous virus known to humans

6

EBV is a human

DNA herpes virus

7

One of the habitats of the persisting viral genome in hosts with a letant infection is the

B lymphocytes of the lymphoreticular system and epithelial cells of the oropharynx

8

In infectious mononucleosis the virus infects

b lymphocytes but the variant lymphocytes produced in response to and seen in microscopic examination of the peripheral blood have T cell characteristics

9

The mononucleosis is not caused by the stimulation of B cells by

viral infection

EBV transform cell lines in vitro but by a large effective CD8 cytotoxic T cell response against EBV infected circulating B lymphocytes

10

although transmitted primary by close contact with

infectious oropharyngeal secretions EBV is reportedly transmitted by blood transfusion and transplacental routes.

11

under normal conditions EBV transmission through

transfusion or trasnplacental exposure is unlikely

12

Immunocompetent persons maintain EBV as a

chronic latent infection

13

EBV is only a minor problem for immunocompetent persons but can become a major concern for immunocompromised

patients

14

The IgM type of heterophil antibody usually appears during the

acute phase of infectious mononucleosis bu the antigen that stimulates its production remains unknown

15

in adult population 10% to 20% of those with acute infectious mononucleosis do not produce

infectious mononucleosis heterophil antibody

16

the pedriatic population is of particular concern because more the 50% of children younger then 4 years with infectious mononucleosis are

HETEROPHIL NEGATIVE

17

anti-VCA IgG is usually detected

4 to 7 days after the onset of signs and symptoms and persists for an extended period perhaps lifelong

18

EBNA is found in the

nucleus of all EBV infected cells

19

ANTI-EBNA IgG does not appear until a patient has entered the convalescent period and or reactivation of

latent infection

20

the mono slide procedure is based on the

agglutination of horse erythrocytes by heterophil antibody present in infectious mononucleosis