Chapter 20

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1

The definitive host of T gondii is the

house cat and certain other felidae.

2

domestic cats are a source of

toxoplasmosis because oocysts are often present in their feces.

3

Accidental ingestion of oocysts by humans and animals including the cat

produces a proliferative infection in their body tissues.

4

Fecal contamination of food and water, soiled hands, inadequately cooked or infected meat and raw milk can be major

source of human infection

5

All mammals including humans can transmit the infection

TRASPLACENTALLY

6

Transplacelta trasmission usually takes place in the course of an

acute but innaparent or undiagnosed maternal infection

7

New evidence indicates that the number of infants born in the US each year

with congenital T gondii infection is considerably higher then the 3000 previously estimated.

8

Congenital toxoplasmosis can result in

CNS malformation, prenatal mortality

9

in infants who are serologically positive at birth many fail to display

neurologic

ophthalmic or

generalized illness at birth

10

Toxoplasmosis acquired in utero can result in

blindness, encephalomyelitis, mental retardation, convulsions and death in infected neonates.

TORCH SYNDROME

11

in as many as 75% of congenitally infected newborns not serologically diagnosed at birth, the disease remains

format, only to become be discovered when other symptoms become apparent such as choriorentitis, unilateral blindness and severe neurologic sequelae

12

The best evidence for current infection is a significant

change in two appropriately timed specimens

(paired acute and convalescent specimens)

and when both tests are down in the same laboratory at the same time

13

The diagnosis of toxoplasmosis can be established by

serologic tests, polymerase chain reaction

indirect fluorescnet antibody

isolation of organism.

14

Many consider enzyme-linked immunosorbent assay (elisa) to be the method of choice for the detection

of IgM antibodies in toxoplasmosis

15

Any positive result in pregnant patient confirmed as positive by a

second reference laboratory should be evaluated by amniocentesis and PCR testing for T gondii

16

A negative result result does n

not rule out the presence of PCR inhibitors in the patient specimen of T gondii DNA concentrations below the level of detection of the assay.

17

PCR amplification is used to

detect T gondii DNA in body fluids and tissues

18

PCR can be used to detect the presence of absence of

T gondii DNA in fresh or frozen biopsy tissue CFS , amniotic fluid, serum, plasma