Study of the urinary system
Urology
The urinary system consist of...
2 kidneys, 2 ureters, unrinary bladder, and urethra
What is the primary function of the urinary system?
To regulate the extracellular fluid in the body, through the production of the kidney filtrate.
What do the kidneys regulate?
1. blood volume
2. concentration of waste products in the blood
3. concentration of electrolytes in the plasma
4. plasma pH
What are the 3 layers of tissue that support and protect the kidney?
renal fascia (outer layer), adipose tissue (middle layer), fibrous renal capsule (inner layer)
blood eventually drains from the peritubular capillaries into the ______ vein system and the ____ _____.
renal, vena cava
Capsule that surrounds the glomerulus
Bowman's (glomerular)
single layer of cuboidal cells whick promote reabsorption of salt, water, and other molecules back into the peritubular capillaries.
proximal convulated tubule
loop in the medulla of the kidney(descending and ascending loop)
nephron loop (Henle's loop)
conducts urine through a pyramid, into a calyx and the pelvis
collectin duct
these are within the visceral layer of the capsule and their cytoplasmic extentions, interdigitate with the glomerular capillaries
podocytes
____________ proteins because of their large size and negative charge, don't leave the capillaries.
plasma
4 basic process of urine formation
1. glomeruli filtration
2. tubule reabsorption
3. tubular secretion
4. concentration
Most salt and water is reabsorbed by _______ from the proximal tubules
osmosis
Reabsorption of water in the distal tubule and collecting duct is regulated by what hormones?
ADH and aldosterone
Na+ is actively transported for the filtrate to the ____________ capillaries wich allow osmosis to occur
peritubular
Thin walled capillary loops that parallel the nephron loops-solutes are trapped a recirculated within the renal medulla, but water is tranported out
vasa recta
walls of collecting ducts are permiable to ____, but not to salt
water
What creates water channels within the walls of collecting ducts?
ADH
ADH is produced by the _________ and secreted from the ________?
hypothalamus, posterior pituatary
__________ in the hypthalamus detect increased salt concentration due to dehydration.
osmoreceptors
inadequate ADH, large volumes of dilute urine are excreted
diabetes insipidus
What are the 3 layers of the ureter?
inner mucosa, muscularis, adventitia
This is located posterior to symphysis pubis and anterior to the rectum
urinary bladder
folds of the urinary bladder which alow distention in the mucosa
rugae
layers of the bladder
mucosa, submucosa, musculairis, adventitia
The muscularis is composed of 3 muscle layers called the ____ _____.
detrusor muscle
This layer of the bladder appears only on the superior surface of the bladder; a contiuation of the peritoneum
adventitia
voluntarty control of urine
micturition
what is normal urine production?
1200 ml
Normal bladder capacity is about ....
700-800 ml
This center is located in the 2nd, 3rd, and 4rth sacral segments of the spinal cord?
micturition reflex center
inability to void or control urine
urinary incontinence
when output exceeds intake over a prolonged period is a called a _____ ______.
fluid deficiency
This disorder is when proportionate amounts of water and sodium are lost?
volume deppletion
The body eliminates more water than Na+ and the ECF osmolarity rises is a deficiency called _____.
dehydration
Important in maintaining fluid homeostasis;react chemically; and strongly affect osmolality
electrolytes
Removal of solutes from the blood either through the ______ filtrate or scretions through the ____ cells.
glomeruli, tubular
_______ is the opposite of reabsorption.
secretion
99% of filtered ______ is reabsorbed?
water
The volume of plasma from which a substance is removed in one minute is called ______ _____ _____.
renal plasma clearance
Urea is secreted by the _______ into the blood?
liver
_______ is a waste product of amino acid metabolism.
urea
Most of the glomerular blood passes unfiltered into the ________ arterioles and ______ capillaries.
efferent, peritubular
Blood must make many passes through the ______ before a substance is completely cleared.
kidneys
____ can be cleared from the blood in the kidneys in a single pass through.
PAH (para-aminohippuric acid)
waste product of muscle metabolism
creantinine
glucose appears in urine because concentration exceeds carrier numbers
glycosuia
the minimum level in blood that results in excretion
renal plasma threshold
A steroid hormone secreted by the adrenal cortex that regulates Na+ and K+ plasma concentrations?
aldosterone
Na+ and K+ are important in _____ _____ and ______ ______.
blood volume, pressure regulation
K+ is also important in ______ and _______ muscle formation.
cardiac, skeletal
Aldosterone conversely stimulates secretion of ___ into the tubules.
K+
Region where the afferent arteriole and distal convoluted in tubule come in contact.
juxtaglomerulus apparatus
Granular cells in the afferent arteriole secrete the hormone ______ which results in aldosterone secretion.
renin
Due to low Na+ concentration stimulates renin secretion fron _____ ______.
granular cells
This hormone stimultes salt excretion
natriuretic
Most important aspects of homeostasis
acid-base control
_______ are constantly produced metabolically
acids
_______ resist changes in pH.
buffers
___________ can neutralize more acid or base than any other system.
kidneys
Renal tubules secrete H+ ion into the ________ fluid where most is bound to ammonia and phosphate buffers and excreted as _______.
tubular, urine
_________ are the only organs which excrete H+ ions.
kidneys
below 7.35 pH
acidosis
above 7.45 pH
alkalosis
kidneys increase H+ secretion in _________
acidosis
________ acids are normally buffered by HCO3-
metabolic
increase urine output
diuretics
urine disorder in which their is paniful elimination.
dysuria
Blood in urine?
hematuria
Bateria in the urine?
bacturia
Pus in urine?
pyuria
insufficient output
oliguris
excessive output
polyuria
inspection of urinary bladder with cytoscope
cytoscopy
test for color, specific gravity, chemical composition, bacteria, crystals, and cast
urinalysis
accumulations of proteins that leaked through the glomeruli
cast
Name some infections of urinary organs?
urethritis, cystitis, nephritis, pyelitis
blow to kidneys; straddle injuries; pelvic injuries to the bladder
trauma
stones, cyst, tumors
obstructions
chronic and accute; can regenerate
renal failure