bare area
area superior to the liver that is not covered by peritoneum so that the inferior vena cava may enter the chest
bilirubin
yellow pigment in bile formed by the breakdown of red blood cells; excreted by the liver and stored in the gallbladder
blood urea nitrogen (BUN)
laboratory measurement of the amount of nitrogenous waste and creatinine in the blood; waste products accumulate in the blood when kidneys malfunction
bull’s eye (target) lesion
hypoechoic mass with an echogenic central core (abscess, metastases)
caudate lobe
smallest lobe of the liver situated on the posterosuperior surface of the left lobe; the ligamentum venosum is the anterior border
collateral circulation
circulation that develops when normal venous channels become obstructed
diffuse hepatocellular disease
affects hepatocytes and interferes with liver function
epigastrium
area between the right and left hypochondrium that contains part of the liver, duodenum, and pancreas
extrahepatic
outside the liver
falciform ligament
extends from the umbilicus to the diaphragm in a sagittal plane and contains the ligamentum teres
hepatocellular disease
classification of liver disease where hepatocytes (liver cells) are the primary problem, as opposed to obstruction of bile secretion
hepatocyte
a parenchymal liver cell that performs all functions ascribed to the liver
hepatofugal
flow away from the liver
hepatopetal
flow toward the liver
hyperglycemia
uncontrolled increase in blood glucose levels
hypoglycemia
deficiency in blood glucose levels
intrahepatic
within the liver
left hypochondrium
left upper quadrant of the abdomen that contains the left lobe of the liver, spleen, and stomach
left lobe of the liver
lies in the epigastrium and left hypochondrium
left portal vein
supplies the left lobe of the liver
ligamentum teres
appears as bright echogenic foci on transverse image; along with falciform ligament, it divides medial and lateral segments of the left lobe of the liver
ligamentum venosum
separates the left lobe from the caudate lobe; shown as an echogenic line on the transverse and sagittal images
liver function tests
specific laboratory tests that look at liver function (aspartate or alanine aminotransferase, lactic acid dehydrogenase, alkaline phosphatase, and bilirubin)
main lobar fissure
boundary between the right and left lobes of the liver; seen as a hyperechoic line on the sagittal image extending from the portal vein to the neck of the gallbladder
main portal vein
vein formed by union of the splenic vein and superior mesenteric vein; serves as the posterior border of the pancreas; enters the liver at the porta hepatis
metastatic disease
tumor that develops away from the site of the organ; most common form of neoplasm of the liver; primary sites are the colon, breast, and lung
neoplasm
any new growth (benign or malignant)
obstructive disease
classification of liver disease where main problem is blocked bile excretion within the liver or biliary system
pyogenic abscess
pus-forming collection of fluid
right hypochondrium
right upper quadrant of the abdomen that contains the liver and gallbladder
right lobe of the liver
largest lobe of the liver
right portal vein
supplies the right lobe of the liver; branches into anterior and posterior segments
area superior to the liver that is not covered by peritoneum so that inferior vena cava may enter the chest
Bare area
smallest lobe of the liver situated on the posteriosuperior surface of the left lobe; the ligamentum venosum is the anterior border
caudate lobe
area between the right and left hypochondrium
epigastrium
extends from the umbilicus to the diaphragm in a sagittal plane and contains the ligamentum teres
falciform ligament
left hypochondrium
left upper quadrant of the abdomen that contains the left lobe of the liver, spleen, and stomach
liver lobe that lies in the epigastium and left hypochondium
left lobe of the liver
supplies the left lobe of the liver
left portal vein
appears as bright echogenic foci on transverse image; along with falciform ligament, it divides medial and lateral segments of left lobe of the liver
ligamentum teres
separates left lobe from caudate lobe; shown as echogenic line on the transverse and sagittal
ligamentum venosum
boundary between the right and left lobes of the liver; seen as hyperechoic line on the sagittal image extending from the portal vein to the neck of the gallbladder
main lobar fissure
enters the liver at the porta hepatis
main portal vein
right upper quadrant of the abdomen that contains the liver and gallbladder
right hypochondrium
largest lobe of the liver
right lobe of the liver
supplies the right lobe of the liver; branches into anterior and posterior segments
right portal vein
alkaline phosphate
enzyme of the liver
ALT
alanine aminotransferase – enzyme of the liver
AST
aspartate aminotransferase – enzyme of the liver
Yellow pigment in bile formed by the breakdown of red blood cells; excreted by liver and stored in the gallbladder
bilirubin
BUN
blood urea nitrogen; laboratory measurement of the amount of nitrogenous waste and creatinine in the blood
classification of liver disease where hepatocytes are the primary problem
hepatocellular disease
parenchymal liver cell that performs all functions ascribed to the liver
hepatocyte
hepatofugal
flow away from the liver
hepatopetal
flow toward the liver
uncontrolled increase in blood glucose levels
hyperglycemia
hypoglycemia
deficiency in blood glucose levels
specific laboratory tests that look at liver function (aspartate or alanine aminotransferase, lactic acid dehydrogenase, alkaline phosphatase, and bilirubin
liver function tests
classification of liver disease where the main problem is blocked bile excretion within the liver of biliary
obstructive disease
hypoechoic mass with an echogenic central core (abscess, metastases)
bull’s-eye (target lesion)
develops when normal venous channels become obstructed
collateral circulation
affects hepatocytes and interferes with liver function
diffuse hepatocellular disease
extrahepatic
outside the liver
intrahepatic
within the liver
most common form of neoplasm of the liver; primary sites are colon, breast, and lung
metastatic
any new growth (benign or malignant)
neoplasm
pus-forming collection of fluid
pyogenic abscess

diaphragm

falciform ligament

gallbladder

inferior border

left lobe

right lobe

right triangular ligament

round ligament
A congenital variant, ___________________, can sometimes be seen as an anterior projection of the liver and may extend inferiorly as far as the iliac crest.
Reidel's lobe
The liver is covered by a thin connective tissue layer called _____________ capsule.
glisson's
The ________ fissure is the boundary between the right and left lobes of the liver.
main lobar
The ____________ ligament extends from the umbilcus to the diaphragm in a parasagittal plane and contains the ligamentum teres
falciform
The ___________ appears as a bright echogenic focus on the sonogram and is seen as the rounded termination of the falciform ligament.
ligamentum teres
The fissure for the ____________ separates the left lobe from the caudate lobe.
ligamentum venosum
The hepatic veins are divided into three components: _____________, _____________, and ______________
left, middle, right
The liver is a major center of _______________, which may be defined as the physical and chemical process whereby foodstuffs are synthesized into complex elements.
metabolism
Through the process of __________, the liver expels these waste products from the body via its excretory product, bile, which plays an important role in fat absorption.
digestion
A pigment released when the red blood cells are broken down is __________.
bilirubin
The liver is a _________ site for several compounds used in a variety of physiologic activities throughout the body.
storage
The liver is also a center for __________ of the waste products of metabolism accumulated from other sources in the body and foreign chemicals that enter the body.
detoxification
Diseases affecting the liver may be classified as ______________ when the liver cells or hepatocytes are the immediate problem; or _____________ when bile excretion is blocked.
hepatocellular, obstruction
Raw materials in the form of ____________, _____________, and _______ are absorbed from the intestine and transported to the liver via the circulatory system.
carbohydrates, fats, amino acids
Sugars may be absorbed from the blood in several forms, but only _________ can be used by cells throughout the body as a source of energy.
glucose
Dietary fats are converted in the hepatocytes to ____________, in which form fats are transproted throughout the body to sites where they are used by other organs or stored,
lipoprotien
The accompanying loss of oncotic pressure in vascular system allows fluid to migrate into the interstitial space, resulting in ___________ dependent areas.
edema
Because the liver is a major center of metabolism, large quantities of _______ are present in hepatocytes, and these leak into the bloodstream when the liver cells are damages of destroyed by disease.
enzymes
In severe hepatocellular destruction, such as acute viral or toxic hepatitis, striking elevation of ____________ and ____________ may be seen.
AST, ALT
Marked elevation of ____________ is typically associated with biliary obstruction or the presence of mass lesions in the liver.
alkaline phosphate
Hemoglobin released from the red cells is converted to _____________ within the reticuloendothelial system and is then released into the bloodstream.
bilirubin
Elevation of serum of serum bilirubin results in ________________, which is a yellow coloration of the skin, sclerae, and body secretions.
jaundice
Embryology
What is the liver derived from?
epithelium of the foregut of the gastrointestinal tract.
Embryology
When does hepatopoiesis begin and end?
six weeks - birth
Explain the microanatomy of the hepatic parenchyma
hepatocytes
reticuloendothelial cells (kupffer cells)
organized into lobules
What is a Kupffer cell?
are specialized macrophages located in the liver lining the walls of the sinusoids that form part of the reticuloendothelial system (RES)
What is another name for ligament teres?
round
(fetal umbilical vein)
What is the ligamentum venosum originate from?
ductus venosum
How is the right lobe subdivided?
anterior and posterior segments
How is the left lobe subdivided?
medial and lateral segments
What does the portal venous system drain?
spleen
digestive
pancreas
GB
What is the relationship between the stomach and the liver
inferior and lateral to the left lobe
What is the reticuloendothelial activity of the liver?
fetal blood production
production of plasma proteins and antibodies
destruction of red blood cells
phagocytosis
What are the 7 functions of the liver?
reticuloendothelial
metabolism
storage
blood reservoir
Heat production
detoxification
What is stored in the liver?
fats
glycogen
amino acids
A, D, B complex
iron / copper
What does the liver detoxify?
medications
hormones
bilirubin
What is AST?
aspartate aminotransferase
What is the significance of AST?
increases with hepatocellular disease
and muscular and skeletal disease
What is ALT
Alanine aminotransferase
What is the significance of ALT?
increases with hepatocellular disease and biliary obstruction
Which is more specific to liver disease, AST ot ALT?
ALT
Diffuse liver disease
hepatocellular disease that affects the entire liver
Fatty
GSD
hepatitis
cirrhosis
What is GDS?
gylcogen storage disease is a autosomal recessive genetic disorder of carbohydrate metabolism
What is the most common type of GDS to affect the liver?
Type I Von Gierke's
What is Pompe DIsease?
GSD Type II affects heart and muscles
What are the common lab values for hepatitis?
marked increase in AST and ALT (falls rapidly)
bilirubin increases
A caudate lobe/ right lobe (C/RL) ratio meaurement increases to greater than .65 What does this imply?
cirrhosis
What is presinusoidal portal hypertension?
Prehepatic
thrombosis in the mesenteric, splenic of portal vein
What is intrahepatic portal hypertension?
offending process occurs at the hepatic level
What is the most common cause of intrahepatic portal hypertension?
cirrhosis
What is posthepatic portal hypertension?
Budd-Chiari
offending process after the hepatic level
thrombosis of the IVC or hepatic veins
True liver cysts are
congenital
epithelial lining
What is the significance of a liver cyst without an epithelial lining?
non-congenital
trauma
parasitic
inflamatory
What is a pyogenic cyst?
pus collection caused by bacteria
most commonly E. coli
What is the sonographic appearance of pyogenic cysts?
thick walls w/ poor definition
air may cause comet-trail
mostly right lobed
What is Amebic abscess
parasitic
generally disease of colon
well defined thin walls
Liver candidiasis
yeast infection
bull's eye or wheel within a wheel
needle aspiration can differentiate from lymphoma
What is the sonographic appearance of echinococcal cysts?
mother/daughter cysts or honeycomb appearance
What are benign neoplasms of the liver?
adenoma
hemangioma
focal nodular hyperplasia
hemangioendothelioma
mesenchymal hamartoma
adenoma
slightly atypical hepatocytes
variable appearance
More common in women taking oral contraceptives
What benign lesion is associated with oral contraceptives?
adenoma
Hemangioma
network of vascular endothelium
usually hyperechoic
hemangioendothelioma
overgrowth of capillary vessels in infants
more common in females
Mesenchymal hamartoma
rare
encapsulated cystic tumor
less than 2 years old
What are malignant tumors of the liver?
hepatoblastoma
hepatocellular carcinoma (HCC) hepatoma
hepatic angiosarcoma
metastasis
hepatoblastoma
malignant germ cell tumor
Most common malignant tumor occurring in 3 years and younger
hepatoblastoma
What is hepatoblastoma associated with?
beckwith- Wiedemann
hepatocellular carcinoma (HCC) hepatoma
most common primary liver tumor
What is the most common predisposing factor for hepatocellular carcinoma (HCC) hepatoma?
cirrhosis
What is the most common site to metastasize?
liver
hepatic angiosarcoma
rare
60 - 80 years
Hematoma
collection of blood
caused by trauma
What is the term for a malignant lesion of the liver?
A) hepatoma
B) focal nodular hyperplasia
C) cavernous hemangioma
D) fibroma
A) hepatoma
Caudate lobe enlargement may be due to:
A) fatty infiltration
B) hepatitis
C) cirrhosis
D) hypertension
...
Which is the most predisposing factor of hepatocellular carcinoma in Western civilization?
A) biliary disease
B) echinococcal cyst
C) cirrhosis
D) portal hypertension
...
Hepatofugal blood flow may be seen in the main portal vein in patients with:
A) cavernous hemangioma
B) biliary disease
C) fatty infiltration
D) portal hypertension
...
The portal triad consists of the:
A) main portal vein, common bile duct, hepatic artery
B) main portal vein, hepatic duct, common bile duct
C) main portal vein, hepatic artery, hepatic vein
D) main portal vein, hepatic artery, hepatic duct
...
A patient presents with weight loss, increased alpha fetal protein (AFP), and abdominal distention. This is most characterisitic of:
A) focal nodular hyperplasia
B) liver adenoma
C) hepatoma
D) lymphoma
...
Which vessels increase in size as they course superiorly toward the diaphragm?
A) hepatic arteries
B) hepatic veins
C) portal veins
D) patent umbilical veins
...
A small hyperechoic nodular liver best describes:
A) acute viral hepatitis
B) chronic viral hepatitis
C) cirrhosis
D) normal pediatric liver
...
Which of the following is a characteristic of Budd-Chiari syndrome?
A) thrombus in the hepatic and portal vein
B) thrombus in the hepatic artery and vein
C) thrombus in the hepatic vein and inferior vena cava
D) thrombus in the hepatic artery and aorta
...
Which of the following are pathological states of the liver does not demonstrate mass- effect on surrounding hepatic vascularity?
A) fatty infiltration
B) diffuse metastasis
C) focal nodular hyperplasia
D) cavernous hemangioma
...
A 30 year old patient presents with abdominal pain and abnormal liver function tests. The abdominal ultrasound reveals a dilated portal and superior mesenteric vein with hepatofugal blood flow. This is most characteristic of:
A) portal aneurysm
B) portal atresia
C) portal fistula
D) portal hypertension
...
Normal dimension for the common hepatic duct is considered to be:
A) less than 2 mm
B) less than 3 mm
C) less than 5 mm
D) less than 7 mm
...
The lesser omentum ligament is also referred to as the :
A) left triangular
B) gastrohepatic
C) falciform
D) ligamentum teres
...
Sonographic findings with acute hepatitis can include all of the following except:
A) periportal cuffing
B) normal liver parenchymal echogenicity
C) decreased liver parenchymal echogenicity
D) decreased echogenicity of portal vein walls
...
The liver function laboratory test which is most specific to hepatocellular disease is:
A) ALP
B) AST
C) ALT
D) bilirubin
...
A cyst within a cyst (daughter cyst) is a characteristic of:
A) polycystic liver disease
B) echinococcal cyst
C) hepatoma
D) pseudocyst
...
When using Brisbane’s liver segmentation, how many segments is the liver divided into?
A) 4
B) 8
C) 9
D) 10
...
The following carries the majority of the oxygen and nutrients to the liver?
A) hepatic artery
B) portal vein
C) common duct
D) celiac axis
...
The patient preparation necessary to examine the liver is:
A) drink 16 ounces of water
B) NPO for 6 hours
C) clear liquids
D) no specific preparation
...
What is the reticuloendothelial function of the liver?
A) phagocytosis of Kupffer cells
B) formation of bile
C) blood reservoir
D) synthesis of amino acids
...
What is the most common predisposing condition for a bacterial abscess of the liver?
A) portal vein thrombosis
B) biliary obstruction
C) hepatic artery aneurysm
D) surgical procedure
...
The fissure of the ligamentum venosum divides the liver into:
A) right and left lobes
B) left lobe and caudate lobe
C) left medial and lateral segments
D) right lobe and caudate lobe
...
A 50 year old diabetic patient presents with abdominal pain and slightly elevated liver function tests. Hepatomegaly and diffuse increase in the liver parenchymal echogenicity are present. This is characteristic of:
A) cirrhosis
B) hepatocellular carcinoma
C) pyogenic infection
D) fatty infiltration
...
A 20 year old asymptomatic woman presents for an abdominal ultrasound. A round hyperechoic, subcapsular mass is identified in the right lobe of the liver. This is most characteristic of:
A) hepatoblastoma
B) cavernous hemangioma
C) echinococcal cyst
D) solitary metastatic lesion
...
Normal Doppler waveform of the hepatic veins demonstrate a “w” appearance. This appearance is attributes to changes in:
A) respiration
B) right ventricular pressure
C) right atrial pressure
D) left ventricular pressure
...
What is the waveform of the portal vein?

low resistance with some phasity
What is the waveform of the hepatic vein?

W shape from influence from cardiac cysle
What is the waveform of the hepatic artery?

low resistance
What is the most common Glycogen storage disease?
Type 1 Von Gierke's
What is type 2 Glycogen storage disease?
...