Pharm: Abx Bact Protein

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created 7 years ago by jgaversa5
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Pharmacology
Chapter 4
updated 7 years ago by jgaversa5
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1

what are the bacterial protein inhibitors

chloramphenicol
tetracyclines
macrolides
linezolid
aminoglycosides

2

what is the spectrum of chloramphenicol

broad

3

what is chloramphenicol used to treat in the third world

bacteroides
n. meningitis
h. flu

4

what is the mechanism of chloramphenicol

50S and block peptidyltranferase

5

hos is reistance conferred vs. chloramphenicol

plasmid of O-acetyltransferase (onto chloram)

6

what are the adverse effects of chloramphenicol

GBG

Gray Baby ssyndrome
BM suppression: ANEMIAS
GI

7

why does gray baby syndrome happen

usually P450 glucuronidation metabolizes the durg, but in kids this is not developed so more chloram is in bloodstream leading to RbC damage and then cyanosis

8

what are the main uses for tetracyclines

Lyme, Lepto
Chlam, Rickettsia, MP
cholera, yersinia, brucella
anthrax

9

what is the mechiansim of tetracyclines

30S blocking aminoacyltransferase

10

is tetracycline considered broad

yes

11

how is resistance conferred against tetracyclines

I, E, proteins to prevent binding

12

what are the adverse effects of tetracyclines

HOPVB

hepatotox
ototox
photosensitivty
vestibulotox
BONE AND TOOTH DEFORMITIES in kids

13

why should you not give tetracyclines to pregnant mothers

beecause they can affect bone and tooth synthesis

14

what should you not take with tetracyclines

multivitamins or dairy

15

what can tigacycline be used for

VRE and MRSA

16

what are the macrolides used for

diptheria
MP, chlamydia, legionnaires
syphillis (if allergic to penicillin)

17

which macrolide would you give for syphillis

erythromycin

18

what is the mechanism of action of macrolides

INHIBIT GLIDE

50S, inhibit translocation (stops A to P)

19

how is resistance to macrolides conferred

I, E, increase in methylase

20

what are the adverse effects of macrolides

acute cholestatic hepatitis
eosinophilia
skin rash

GD ACHES: GI, drug interactions, acute cholestatic hepatitis, eosinophilia, skin rash

21

what is clindamycin used for

anaerobes but can't treat c. diff

22

what can clindamycin actually cause

c. diff

23

what is interesting about the effect of azithromycin

goes longer than the dosage by like 36 hour halflife

24

what is erythromycin thought to be safe for

to give in pregnancy

25

what is linezolid for

resistant GPC, clostridium, TB

26

what is the mechanism of linezolid

50S, inhibits translocation

27

what is the resistance to linezolid

I, E, modification of binding site

28

what are the adverse effects of linezolid

NODS

neuropathy, optic neuritis, dose related anemia, serotonin syndrome

29

what is serotonin syndrome

hyperthermia, hyperreflexia, tremors, diarrhea, rising BP, myadriatic

(everything sym except diarrhea)

30

what are two important things about aminoglycoside drugs

bacteriocidal
broad spectrum

31

what are the uses of aminoglycosides

PETS

psudomonas
enterococci
tularemia
yersinia
brucella

32

what is the mechanism of aminoglycosides

30S, misread mRNA, blocks translation

33

how is resistanct to AGs gained

plasmids (transferases)

34

what are the adverse effects of AGs

CNNVO

contact derm with neomycin
nephrotox
neuromucuslar paralysis
vertigo
ototox

35

who should you not give AGs

pregnant women