Chapter 8

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Pharmacology
Chapter 8
OTC drugs and drug interactions
updated 7 years ago by MeaganShanahan
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1

the fibrate group of antilipidemics has an _______________ on anticoagulants

increased effects, and may cause bleeding

2

Lovastin has _____________effect on anticoagulants

increased

3

Asprin has___________ effect on anticoagulants

increased and can cause bleeding

4

barbituates have a ____________ effect on anticoagulants

reduced

5

NSAIDS such as diclofenac, ketoprofen, tolmentin may___________ effects of anticoagulants

increase

6

The absorption process of laxatives may ______________ gastric emptying.

speed

7

the absorption process of narcotics may_________
gastric emptying.

slow

8

Decrease gastric motility
increase drug absorption or
decrease drug absorption depending on where the drug is delayed(gastric v intestinal)

Anticholergics (beta blockers, antiulcers, digoxin, furosemide,amitriptaline, hycosamine)

9

Decreases gastric ph
increases drug absorption

Asprin

10

increase gastric ph
slows absorption of acid drugs

antacids

11

form drug complexes

antacids and tetracycline

12

decrease cardiac output and renal blood flow
promotes the excretion of weak base drugs(quinidine,theophylline)

asprin

13

promotes the excretion of weak acids drug(asprin, barbituates)

antacids sodium bicarbonates

14

Decrease the excretion of PCN by conpeteing for renal tubular secretion

anti gout medication probenecid

15

Decreases renal excretion of second drug- ex digoxin
increases digioxin concentration

Antirhythmitic quinidine

16

Promotes induction of liver enzymes
increases drug metabilism

barbituates

17

Anticoagulants + antiinflamatory(sulindac)

compete for protein binding sites and increases free drug