Micro: Gram Negative Bacilli of Medical Importance

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created 8 years ago by jgaversa5
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1

what is the only way that shigella and e. coli are distinguished

shigella cause bacillary dysentery, e. coli do not

2

how many serogroups of shigella are there

4

3

what are the serogroups of shigella based on

O carbohydrate antigens

4

are there animal cariers of shigella

no

5

where does shigella live

colon

6

how is shigella transmitted

fecal oral

7

what does shigella invade in the colon

mucosa, rarely past epitheilal cells

8

is shigella septicemia rate high

no

9

what does severity of shigella illness depend on

serogroup cuasing infection

10

what is the milder shigella species

snonei

11

what is the more severe shigella species

s. dysentriae

12

how many cases of shigella are due to s. sonnei

75%

13

how many causes do children under 5 account for

50%

14

what is the correlation between shigella disease severity and amount of toxin produced

more toxin, more severe disease

15

what types of effects does shiga toxin have

neurotoxic
cytotoxic
enterotoxc

16

what are the parts of the shiga toxin

A and 5 B subunits

17

how many parts of the A subunit are there in shiga toxin

A1 and A2

18

what does the A1 peptides of shiga toxin do

irreversibly inactivates 60S ribosomal subunit resulting in inhibition or protein synthesis

19

what is the role of B subunit in shiga toxin

binding of toxin to mucosal cell

20

what is the role of shiga toxin in disease

unclear as toxin-negative strains can still cause disease

21

what will the gram stains of shigella look like

GNR, non lactose fermentes

22

is there H2S production by shigella

no

23

what type of biochemical tests/serology can be used to ID shigella

anti-O antibody agglutination

24

what types of stool exam would ID shigella

methylene blue: presence of PMNs suggests invasive organism like salmonella, shigella, campylobacter

25

what are the treatments for shigella

antibiotics can help, public health measures

26

what family is just like the salmonella family in genetics

arizona

27

where did arizona and salmonella have a commmon ancestor

s. enterica

28

what are the 3 main types of salmonella

typhi
choleraesuis
enteritidis

29

which type of salmonella only infects humans

typhi

30

how many serotypes are there of salmonella tyhphi and choleraesuis

1 each

31

how many salmonella enteritidis serotypes are there

shit ton

32

what is the clincal manifestation of s. typhii

typhoid fever

33

what happens in typhoid fever

fever
delirium
abdomen tender
enlarged spleen
"rose spots"

34

what are the rose spots of typhoid fever

rose colored papules on abdomen

35

how long does tyhpoid fever last

3-4 weeks

36

how many of typhii infected become chronic carriers

3%

37

how do typhii infected people become chronic carriers

GB infection

38

how is typhii tranmitted

fecal-oral

39

where does infection of typhii begin

SI, but few GI symptoms

40

where does typhii multiply

Peyer's patches

41

how does typhii spread

reticuloendotheila system in liver ans pleen

42

what is fever in typhii due to

bacteremia and endotoxin

43

where can s. typhii survive and grow

inside MPs

44

what is a virulence factor of s. typhii

capsule

45

what is improtant to defend vs. s. typhii infection

gastric acid

46

what will gram stain show with typhii

GNR
non lactose fermenter

47

does s. typhii make H2S

yes small

48

how would you identify s. typhii species

serologic tests

49

how would you treat typhii

quinolones, chloramphenico

50

how would you prevent typhii

clean water supply

51

what are the s. typhii vaccines

killed whole bacterial vaccine

live attenuated oral vaccine

killed purified vaccine

52

what are the clinical manifestationso f s. enteritidis/cholerasuis

gastroenteritis
septicemia
enteric fevers

53

how long after ingesting s. enteritids will you get an illness

18-24 hours

54

what are the symptoms of s. enteritids gastroenteritis

diarrhea, fever, abdrominal pain

55

how long does s. enteriditis gastroenteritis last

2-5 days

56

will s. enteritis remain in the colon after an acute infection

yes for a couple weeks

57

what are symptoms of s. enteritidis speticemia

prolonged fever chills anorexia anemia

58

what are the secondary infections of s. enteritiis septicemia

osteomyelitis
pneumonia
pulmonary abscess
meningitis
endocarditis

59

is there gastroenteritis in septicemia s. enteritidis

minor or absent

60

what is s. cholerasuis associated with

septicemia and osteomyelitis in sickle cell patients

61

what are s. enteritidis enteric fever symptoms similar to

typhoid fever but milder and lower mortality

62

what are the symptoms of s. enteritidis enteric fever

initial lethargy, fever, malaise, myalgia

later: bacteremia with high fever and delirium

can develop rose spots and tender abdomen

63

what time will s. enteritidis enteric fever resolve in

3-4 weeks

64

what could be at the end of a s. enteridisis enteric fever

intestinal performation

65

where does s. enteritidis reside

enteric tracts of animals and humans

66

what are the most frequent animal sources of s. enteriditis

chickens, eggs, pet reptiles

67

what is the transmission route of s. enteritidis

fecal oral

68

what does s. enteritis invade

small and large intestine then blood to cause sepsis in 5-10%

69

what are the virulence factors of s. enteritis

endotoxin

70

what is an important host defense against s. enteritidis

gastric acid

71

what would a gram stain of s. enteritids look like

GNR
non lactose fermenting

72

does s. enteritids make H2S

yes

73

where would you isolate and ID biochem/serologically from in gastroenteritis

stool

74

where would you isolate and ID biochem/serologically in enteric fevers

blood

75

should you give s. enteritids people antidiarrheals

no

76

how is sepsis of s. enteridis treated

quinolones and chloramphenicol

77

how would you prevent s. enteritidis

cook poultry, dont eat raw eggs, no reptile pets especially with young kids

78

what things do salmonella and edwardsiella have in common

biochem and epidemiology

79

how do arizona ferment lactose

slowly

80

how is arizona acquired

feces of chicaken, domestic anomals, dried eggs

81

what types of disease do arizonas cause

enterocolitis and enteric fevers also (like salmonella)