Micro: Gram Negative Cocci

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1

how are gram negative bacteria first divided

shape: cocci vs. bacilli

2

how are the gram negative cocci first divided

growth in air: veillonella (no) vs. neisseria (yes)

3

how are the neisserias divided

growth on thayer martin medium: neisseria species (no) vs. yes

4

how is n. gonorrhea distinguished from n. meningitidis

maltose fermentation in meningitis but not in gonorrhea

5

how does n. meningitidis enter the body

respiratory trac

6

how does n. gonorrheae enter the body

genital tract

7

does n. meningitidis have a polysaccharide capsule

yes

8

does n. gonorrhae have a polysaccharide capsule

no

9

does n meningitidis make beta-lactamase

no

10

does n. gonorrhae make beta lactamase

yes

11

is there a vaccine for n. meningitidis

yes

12

is there a vaccine for n. gonorrhae

no

13

what are the clinical manifestations of n. meningitidis

meningococcemia
meningitis

14

what is the most severe form of meningococcemia

waterhouse-friederichsen syndrome

15

what are the symptoms of meningococcemia

high fever
shock
widespread purpura
adrenal insufficiency
DIC

16

what is meningitis above the age of 2 months due to

pneumococcus and meningococcus

17

what cause of meningitis has decreased due to a vaccine

h. influenzae

18

what causes meningitis in newborn infants and immunsuppressed peopl

listeria

19

what are the symptoms of meningitis

fever
headache
stiff neck
petechial/purpuric rash

20

what is the only host of n. meningitidis

humans

21

where does n. meningitidis colonize

nasopharynx

22

how can n. meningitidis disseminate

blood (meningococcemia)
meninges (meningitis)

23

how many people may be carriers

5% of children/young adults

24

how quickly do carriers develop a protective antibody vs. n. meningitidis

within 2 weeks

25

how is n. meningitidis transmitted

cough (respiratory droplets)

26

what are the virulence factors of n. meningitidis

antiphagocytic polysaccharide capsule
endotoxin
makes IgA protease

27

what does resistance to n. meningitidis disease depend on

antibody against polysaccharide capsule

28

what deficiency predisposes one to n. meningitidis infection

C5-C8

29

what does n. meningitidis look like on the lab diagnosis

gram negative kidney bean diplococi

30

is n. meningitidis oxidase positive

yes

31

what type of agar does n. meningitidis grow on

chocolate

32

does n. meningitidis ferment maltose

yep

33

what is elevated in CSF in meningitis

WBCs

34

what is the treatment for n. meningitidis

penicillin

35

what types of n. meningitidis does MPSV protect against

A, C, Y, W-135

36

what types of n. meningitidis does MCV protect against

A, C, Y, W-135

37

does MCV or MPSV give better protection from meningitis

MCV longer lasting

38

is there a vaccine vs. the B subtyep of n. meningitidis

no

39

how many cases of meningococcus are caused by subtype B

1/3

40

how many of cases in infants of one year or younger are caused by subtype B

65%

41

what is the clinical manifestation of n. gonorrhoeae

gonorrhea

42

is gonorrhea usually symptomatic in men

yes

43

can gonorrhea be asymptomatic in females

yes

44

what does n. gonorrhea infect

genital tract mostly

can infect pharynx and anorectal area as well

45

do some n. gonorrhoeae infect systemically

yes

46

how is sytemic n. gonorrhoeae manifested systemically

fever
rash
tenosynovitis/arthritis

47

what does n. gonorrhoeae urethritis cause

dysuria and discharge

48

what does n. gonorrhoeae endocervitis cause

purulant discharge, can acedend to cause salpingitis and PID which could result in infertility

49

what can n. gonorrhoeae cause in newborns

purulent conjunctivitis

50

how is n. gonorrhoeae transmitted

sexually in adults

newborns infected at birth by passing through infected birth canal

51

what are the virulence factors of n. gonorrhoeae

endotoxin
IgA proatease

52

does n. gono have a polysacch capsule

no

53

how are serotypes of n. gono caused

antigenicity of pilus protein

54

what is the role of pili in n. gono

mediate attachement to mucosal surfaces and are antiphagocytic

55

is non piliated GC pathogenic

no

56

how many OMP (outer membrane proteins) does N. gono happen

3

57

what does OMP II do

plays role in attachment to mucosal surfaces

58

are labs for n. gonorrhoeae

gram negative kidney bean diploccoi

59

is n. gono oxidase positive

yes

60

what type of media can n. gono

Thayer media (5% CO2)

61

is maltose fermented by n. gono

no

62

is n. gono resistant to penicllin

high level

63

how is n. gono resistant to penicillin

plasma encoded penicillinase production

64

how is n. gono treated

ceftriaxone

65

is there an n. gono vaccine

no