Micro: Endotoxin

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created 8 years ago by jgaversa5
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updated 8 years ago by jgaversa5
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1

what are the biologic effects of endotoxin

fever due to release by MPs of endogenous pyrogen (IL-1) which acts on hypothalamic temperature regulatory center

hypotension, shock, and impaired perfusion of vital organs due to vasodilation and incrased vascular permeability

disseminated intravascular coagulation due to activation of coagulation system

activation of MPs, incrase phagocytosis, activation of clones of B cells increaseing Ab production

2

what are the main parts of endotoxin

O polysacch antigen

core

lipid A

3

what are the main cytokines that endotoxins cause

IL-1 and TNF