neur/o, neur/I
nervous system, nervous tissue, nerve
Ex. Neurotrophin
factor that promotes nerve growth (troph/o = nourish)
gli/o
neuroglia
Ex. glial
pertaining to neuroglia
gangli/o, ganglion/o
ganglion
Ex. ganglioma
tumor of a ganglion
mening/o, meninge/o
meninges
Ex. meningocele
hernia of the meninges
myel/o
spinal cord (also bone marrow)
Ex. hematomyelia
hemorrhage into the spinal cord
radicul/o
spinal nerve root
Ex. radiculopathy
any disease of a spinal nerve root
encephal/o
brain
Ex. anencephaly
absence of a brain
cerebr/o
cerebrum (loosely, brain)
Ex. infracerebral
below the cerebrum
cortic/o
cerebral cortex, outer portion
Ex. corticospinal
pertaining to the cerebral cortex and spinal cord
cerebell/o
cerebellum
Ex. supracerebellar
above the cerebellum
thalam/o
thalamus
Ex. thalamotomy
incision of the thalamus
ventricul/o
cavity, ventricle
Ex. intraventricular
within a ventricle
medull/o
medulla oblongata (also spinal cord)
Ex. medullary
pertaining to the medulla
psych/o
mind
Ex. psychogenic
originating in the mind
narc/o
stupor, unconsciousness
Ex. narcosis
state of stupor induced by drugs
somn/o, somn/i
sleep
Ex. Somnolence
sleepiness
-phasia
speech
Ex. heterophasia
uttering words that are different from those intended
-lalia
speech, babble
Ex. coprolalia
compulsive use of obscene words (copro- means “feces”)
-lexia
reading
Ex. bradylexia
slowness in reading
-plegia
paralysis
Ex. tetraplegia
paralysis of all four limbs
-paresis
partial paralysis
Ex. hemiparesis
partial paralysis of one side of the body
-lepsy
seizure
Ex. narcolepsy
condition marked by sudden episodes of sleep
-phobia
persistent, irrational fear
Ex. agoraphobia
fear of being in a public place (from Greek agora, meaning “marketplace”)
-mania
excited state, obsession
Ex. megalomania
exaggerated self-importance; “delusions of grandeur”
afferent
Carrying toward a given point, such as the sensory neurons and nerves that carry impulses toward the CNS (root fer means “to carry”)
arachnoid mater
The middle layer of the meninges (from the Greek word for spider, because this tissue resembles a spider web)
autonomic nervous system (ANS)
The division of the nervous system that regulates involuntary activities, controlling smooth muscles, cardiac muscle, and glands; the visceral nervous system
axon
The fiber of a neuron that conducts impulses away from the cell body
brain
The nervous tissue contained within the cranium; consists of the cerebrum, diencephalon, brainstem, and cerebellum (root: encephal/o)
brainstem
The part of the brain that consists of the midbrain, pons, and medulla oblongata
central nervous system (CNS)
The brain and spinal cord
cerebellum
The posterior portion of the brain dorsal to the pons and medulla; helps to coordinate movement and to maintain balance and posture (cerebellum means “little brain”) (root: cerebell/o)
cerebral cortex
The cerebrum's thin surface layer of gray matter (the cortex is the outer region of an organ) (root: cortic/o)
cerebrum
The large upper portion of the brain; it is divided into two hemispheres by the longitudinal fissure (root: cerebr/o)
cerebrospinal fluid (CSF)
The watery fluid that circulates in and around the brain and spinal cord as a protection
cranial nerves
The 12 pairs of nerves that are connected to the brain
dendrite
A fiber of a neuron that conducts impulses toward the cell body
diencephalons
The part of the brain that contains the thalamus, hypothalamus, and pituitary gland; located between the cerebrum and the brainstem
dura mater
The strong, fibrous outermost layer of the meninges
efferent
Carrying away from a given point, such as the motor neurons and nerves that carry impulses away from the CNS (root fer means “to carry”)
ganglion
A collection of nerve cell bodies outside the CNS (plural: ganglia) (root: gangli/o, ganglion/o)
gray matter
Unmyelinated tissue of the nervous system
gyrus
A raised convolution of the surface of the cerebrum (plural: gyri)
hypothalamus
The part of the brain that controls the pituitary gland and maintains homeostasis
interneuron
Any neuron located between a sensory and a motor neuron in a neural pathway, such as the neurons that transmit impulses within the CNS
medulla oblongata
The portion of the brain that connects with the spinal cord. It has vital centers for control of respiration, heart rate, and blood pressure (root: medull/o). Often called simply medulla
meninges
The three membranes that cover the brain and spinal cord (singular: meninx) (root: mening/o, meninge/o)
midbrain
The part of the brainstem between the diencephalon and the pons; contains centers for coordination of reflexes for vision and hearing
motor
Producing movement; describes neurons that carry impulses away from the CNS
myelin
A whitish, fatty substance that surrounds certain axons of the nervous system
neuroglia
The supportive cells of the nervous system; also called glial cells (from glia meaning “glue;” root: gli/o)
neuron
The basic unit of the nervous system; a nerve cell
neurotransmitter
A chemical that transmits energy across a synapse. Examples are epinephrine, acetylcholine (a-sē-til-KŌ-lēn), serotonin (ser-ō-TŌ-nin), and dopamine (DŌ-pa-mēn)
nerve
A bundle of nerve cell fibers outside the CNS (root: neur/o)
parasympathetic nervous system
The part of the automatic nervous system that reverses the response to stress and restores homeostasis. It slows heart rate and respiration rate and stimulates activity of the digestive, urinary, and reproductive systems.
peripheral nervous system (PNS)
The portion of the nervous system outside the CNS
pia mater
The innermost layer of the meninges
pons
A rounded area on the ventral surface of the brainstem; contains fibers that connect regions of the brain; adjective: pontine (PON-tēn)
reflex
A simple, rapid, and automatic response to a stimulus
root
A branch of a spinal nerve that connects with the spinal cord; the dorsal (posterior) root joins the dorsal gray horn of the spinal cord; the ventral (anterior) root joins the ventral gray horn of the spinal cord (root: radicul/o)
sensory
Describing neurons that carry impulses toward the CNS
somatic nervous system
The division of the nervous system that controls skeletal (voluntary) muscles
spinal cord
The nervous tissue contained within the spinal column; extends from the medulla oblongata to the second lumbar vertebra (root: myel/o)
spinal nerves
The 31 pairs of nerves that connect with the spinal cord
sulcus
A shallow furrow or groove, as on the surface of the cerebrum (plural: sulci)
sympathetic nervous system
The part of the autonomic nervous system that mobilizes a response to stress; increases heart rate and respiration rate and delivers more blood to skeletal muscles
synapse
The junction between two neurons; also the junction between a motor neuron and a muscle or gland
thalamus
The part of the brain that receives all sensory impulses, except those for the sense of smell, and directs them to the proper portion of the cerebral cortex (root: thalam/o)
tract
A bundle of nerve cell fibers within the CNS
ventricle
A small cavity, such as one of the cavities in the brain in which CSF is produced (root: ventricul/o)
visceral nervous system
The autonomic nervous system
white matter
Myelinated tissue of the nervous system
Alzheimer disease (AD)
A form of dementia caused by atrophy of the cerebral cortex; presenile dementia
amyloid
A starchlike substance of unknown composition that accumulates in the brain in Alzheimer and other diseases
aneurysm
A localized abnormal dilation of a blood vessel that results from weakness of the vessel wall; an aneurysm may eventually burst
aphasia
Specifically, loss or defect in speech communication (from Greek phasis, meaning “speech”). In practice, the term is applied more broadly to a range of language disorders, both spoken and written. May affect ability to understand speech (receptive aphasia) or the ability to produce speech (expressive aphasia). Both forms are combined in global aphasia
astrocytoma
A neuroglial tumor composed of astrocytes
cerebral contusion
A bruise to the surface of the brain following a blow to the head
cerebrovascular accident (CVA)
Sudden damage to the brain resulting from reduction of cerebral blood flow; possible causes are atherosclerosis, thrombosis, or a ruptured aneurysm; commonly called stroke
coma
State of deep unconsciousness from which one cannot be roused
concussion
Injury resulting from a violent blow or shock; a concussion of the brain usually results in loss of consciousness
confusion
A state of reduced comprehension, coherence, and reasoning ability resulting in inappropriate responses to environmental stimuli
contrecoup injury
Damage to the brain on the side opposite the point of a blow as a result of the brain's hitting the skull (from French, meaning “counterblow”)
convulsion
A series of violent, involuntary muscle contractions. A tonic convulsion involves prolonged contraction of the muscles; in a clonic convulsion there is alternation of contraction and relaxation. Both forms appear in grand mal epilepsy
dementia
A gradual and usually irreversible loss of intellectual function
embolism
Obstruction of a blood vessel by a blood clot or other material carried in the circulation
encephalitis
Inflammation of the brain
epidural hematoma
Accumulation of blood in the epidural space (between the dura mater and the skull)
epilepsy
A chronic disease involving periodic sudden bursts of electric activity from the brain, resulting in seizures
glioma
A tumor of neuroglia cells
hemiparesis
Partial paralysis or weakness of one side of the body
hemiplegia
Paralysis of one side of the body
hydrocephalus
Increased accumulation of CSF in or around the brain as a result of obstruction to flow. May be caused by tumor, inflammation, hemorrhage, or congenital abnormality
insomnia
Insufficient or nonrestorative sleep despite ample opportunity to sleep
meningioma
Tumor of the meninges
meningitis
Inflammation of the meninges
multiinfarct dementia (MID)
Dementia caused by chronic cerebral ischemia (lack of blood supply to the tissues) as a result of multiple small strokes. There is progressive loss of cognitive function, memory, and judgment as well as altered motor and sensory function
multiple sclerosis (MS)
A chronic, progressive disease involving loss of myelin in the CNS
narcolepsy
Brief, uncontrollable episodes of sleep during the day
neurilemoma
A tumor of the sheath (neurilemma) of a peripheral nerve; schwannoma
paralysis
Temporary or permanent loss of function. Flaccid paralysis involves loss of muscle tone and reflexes and degeneration of muscles. Spastic paralysis involves excess muscle tone and reflexes but no degeneration
parkinsonism
A disorder originating in the basal ganglia and characterized by slow movements, tremor, rigidity, and masklike face. Also called Parkinson disease
seizure
A sudden attack, as seen in epilepsy. The most common forms of seizure are tonic–clonic, or grand mal (gran mal) (from French, meaning “great illness”); absence seizure, or petit mal (pet-Ē mal), meaning “small illness;” and psychomotor seizure
shingles
An acute viral infection that follows nerve pathways causing small lesions on the skin. Caused by reactivation of the virus that also causes chickenpox (varicella–zoster virus). Also called herpes zoster (HER-pēz ZOS-ter)
sleep apnea
Brief periods of breathing cessation during sleep
stroke
Sudden interference with blood flow in one or more cerebral vessels leading to oxygen deprivation and necrosis of brain tissue; caused by a blood clot in a vessel (ischemic stroke) or rupture of a vessel (hemorrhagic stroke). Cerebrovascular accident (CVA)
subdural hematoma
Accumulation of blood beneath the dura mater
thrombosis
Development of a blood clot within a vessel
tremor
A shaking or involuntary movement
carotid endarterectomy
Surgical removal of the lining of the carotid artery, the large artery in the neck that supplies blood to the brain
cerebral angiography
Radiographic study of the blood vessels of the brain after injection of a contrast medium
electroencephalography (EEG)
Amplification, recording, and interpretation of the brain’s electric activity
L-dopa
A drug used in the treatment of parkinsonism; levodopa
lumbar puncture
Puncture of the subarachnoid space in the lumbar region of the spinal cord to remove spinal fluid for diagnosis or to inject anesthesia; spinal tap
polysomnography
Simultaneous monitoring of a variety of physiologic functions during sleep to diagnose sleep disorders
anxiety
A feeling of fear, worry, uneasiness, or dread
Asperger syndrome
A behavioral condition on a continuum with autism that may include difficulty with social interactions and understanding, strong specific interests, and repetitive behaviors
attention-deficit hyperactivity disorder (ADHD)
A condition that begins in childhood and is characterized by attention problems, easy boredom, impulsive behavior, and hyperactivity
autism
A disorder of unknown cause consisting of self-absorption, lack of response to social contact and affection, preoccupations, stereotyped behavior, and resistance to change (from auto-, “self” and -ism, “condition of”)
bipolar disorder
A form of depression with episodes of mania (a state of elation); manic depressive illness
delusion
A false belief inconsistent with knowledge and experience
depression
A mental state characterized by profound feelings of sadness, emptiness, hopelessness, and lack of interest or pleasure in activities
dysthymia
A mild form of depression that usually develops in response to a serious life event (from dys- and Greek thymos, meaning “mind, emotion”)
hallucination
A false perception unrelated to reality or external stimuli
mania
A state of elation, which may include agitation, hyperexcitability, or hyperactivity (adjective: manic)
obsessive-compulsive disorder (OCD)
A condition associated with recurrent and intrusive thoughts, images, and repetitive behaviors performed to relieve anxiety
panic disorder
A form of anxiety disorder marked by episodes of intense fear
paranoia
A mental state characterized by jealousy, delusions of persecution, or perceptions of threat or harm
phobia
An extreme, persistent fear of a specific object or situation
posttraumatic stress disorder (PTSD)
Persistent emotional disturbances that follow exposure to life-threatening, catastrophic events, such as trauma, abuse, natural disasters, and warfare
psychosis
A mental disorder extreme enough to cause gross misperception of reality with delusions and hallucinations
schizophrenia
A poorly understood group of severe mental disorders with features of psychosis, delusions, hallucinations, and withdrawn or bizarre behavior (schizo means “split” and phren means “mind”)
acetylcholine
A neurotransmitter; activity involving acetylcholine is described as cholinergic
basal ganglia
Four masses of gray matter in the cerebrum and upper brainstem that are involved in movement and coordination
blood–brain barrier
A special membrane between circulating blood and the brain that prevents certain damaging substances from reaching brain tissue
Broca area
An area in the left frontal lobe of the cerebrum that controls speech production
circle of Willis
An interconnection (anastomosis) of several arteries supplying the brain, located at the base of the cerebrum; cerebral arterial circle
contralateral
Affecting the opposite side of the body
corpus callosum
A large band of connecting fibers between the cerebral hemispheres
dermatome
The area of the skin supplied by a spinal nerve; term also refers to an instrument used to cut skin for grafting (see Chapter 21)
ipsilateral
On the same side; unilateral
leptomeninges
The pia mater and arachnoid together
norepinephrine
A neurotransmitter very similar in chemical composition and function to the hormone epinephrine; also called noradrenalin
nucleus
A collection of nerve cells within the central nervous system
plexus
A network, as of nerves or blood vessels
pyramidal tracts
A group of motor tracts involved in fine coordination. Most of the fibers in these tracts cross in the medulla to the opposite side of the spinal cord and affect the opposite side of the body. Fibers not included in the pyramidal tracts are described as extrapyramidal.
reticular activating system (RAS)
A widespread system in the brain that maintains wakefulness
Schwann cells
Cells that produce the myelin sheath around peripheral axons
Wernicke area
An area in the temporal lobe concerned with speech comprehension
amyotrophic lateral sclerosis (ALS)
A disorder marked by muscular weakness, spasticity, and exaggerated reflexes caused by degeneration of motor neurons; Lou Gehrig disease
amnesia
Loss of memory
apraxia
Inability to move with purpose or to use objects properly
ataxia
Lack of muscle coordination; dyssynergia
athetosis
Involuntary, slow, twisting movements in the arms, especially the hands and fingers
Bell palsy
Paralysis of the facial nerve
berry aneurysm
A small saclike aneurysm of a cerebral artery
catatonia
A phase of schizophrenia in which the patient is unresponsive; there is a tendency to remain in a fixed position without moving or talking
cerebral palsy
A nonprogressive neuromuscular disorder usually caused by damage to the CNS near the time of birth. May include spasticity, involuntary movements, or ataxia
chorea
A nervous condition marked by involuntary twitching of the limbs or facial muscles
claustrophobia
Fear of being shut in or enclosed (from Latin claudere, “to shut”)
compulsion
A repetitive, stereotyped act performed to relieve tension
Creutzfeldt–Jakob disease (CJD)
A slow-growing degenerative brain disease caused by a prion (PRĪ-on), an infectious protein. Related to bovine spongiform encephalopathy (BSE, “mad cow disease”) in cattle
delirium
A sudden and temporary state of confusion marked by excitement, physical restlessness, and incoherence
dysarthria
Defect in speech articulation caused by lack of control over the required muscles
dysmetria
Disturbance in the path or placement of a limb during active movement. In hypometria, the limb falls short; in hypermetria, the limb extends beyond the target
euphoria
An exaggerated feeling of well-being; elation
glioblastoma
A malignant astrocytoma
Guillain–Barré syndrome
An acute polyneuritis with progressive muscular weakness that usually occurs after a viral infection; in most cases recovery is complete, but may take several months to years
hematomyelia
Hemorrhage of blood into the spinal cord, as from an injury
hemiballism
Jerking, twitching movements of one side of the body
Huntington disease
A hereditary disease of the CNS that usually appears between ages 30 and 50. The patient shows progressive dementia and chorea, and death occurs within 10 to 15 years
hypochondriasis
Abnormal anxiety about one's health
ictus
A blow or sudden attack, such as an epileptic seizure
lethargy
A state of sluggishness or stupor
migraine
Chronic intense, throbbing headache that may result from vascular changes in cerebral arteries. Possible causes include genetic factors, stress, trauma, and hormonal fluctuations. Headache might be signaled by visual disturbances, nausea, photophobia, and tingling sensations
neurofibromatosis
A condition involving multiple tumors of peripheral nerves
neurosis
An emotional disorder caused by unresolved conflicts, with anxiety as a main characteristic
paraplegia
Paralysis of the legs and lower part of the body
parasomnia
Condition of having undesirable phenomena, such as nightmares, occur during sleep or become worse during sleep
quadriplegia
Paralysis of all four limbs; tetraplegia
Reye syndrome
A rare acute encephalopathy occurring in children after viral infections. The liver, kidney, and heart may be involved. Linked to administration of aspirin during a viral illness
sciatica
Neuritis characterized by severe pain along the sciatic nerve and its branches
somatoform disorders
Conditions associated with symptoms of physical disease, such as pain, hypertension, or chronic fatigue, with no physical basis
somnambulism
Walking or performing other motor functions while asleep and out of bed; sleepwalking
stupor
A state of unconsciousness or lethargy with loss of responsiveness
syringomyelia
A progressive disease marked by formation of fluid-filled cavities in the spinal cord
tic
Involuntary, spasmodic, recurrent, and purposeless motor movements or vocalizations
tic douloureux
Episodes of extreme pain in the area supplied by the trigeminal nerve; also called trigeminal neuralgia
tabes dorsalis
Destruction of the dorsal (posterior) portion of the spinal cord with loss of sensation and awareness of body position, as seen in advanced cases of syphilis
Tourette syndrome
A tic disorder with intermittent motor and vocal manifestations that begins in childhood. There also may be obsessive and compulsive behavior, hyperactivity, and distractibility
transient ischemic attack
A sudden, brief, and temporary cerebral dysfunction usually caused by interruption of blood flow to the brain
Wallerian degeneration
Degeneration of a nerve distal to an injury
whiplash
Cervical injury caused by rapid acceleration and deceleration resulting in damage to muscles, ligaments, disks, and nerves
Babinski reflex
A spreading of the outer toes and extension of the big toe over the others when the sole of the foot is stroked. This response is normal in infants but indicates a lesion of specific motor tracts in adults
evoked potentials
Record of the electric activity of the brain after sensory stimulation. Included are visual evoked potentials (VEPs), brainstem auditory evoked potentials (BAEPs), and somatosensory evoked potentials (SSEPs), obtained by stimulating the hand or leg. These tests are used to evaluate CNS function
Glasgow coma scale
A system for assessing level of consciousness by assigning a score to each of three responses: eye opening, motor responses, and verbal responses
positron emission tomography (PET)
Use of radioactive glucose or other metabolically active substances to produce images of biochemical activity in tissues. Used for study of the living brain, both healthy and diseased, and also in cardiology
Romberg sign
Inability to maintain balance when the eyes are shut and the feet are close together
sympathectomy
Interruption of sympathetic nerve transmission either surgically or chemically
trephination
Cutting a piece of bone out of the skull; the instrument used is a trepan (tre-PAN) or trephine (tre-FIN)
antianxiety agent
Relieves anxiety by means of a calming, sedative effect on the CNS; for example, chlordiazepoxide (Librium), diazepam (Valium), alprazolam (Xanax); anxiolytic
antidepressants (other than those listed in separate categories below)
Block the reuptake of neurotransmitters such as serotonin, norepinephrine, dopamine, alone or in combination; for example, bupropion (Wellbutrin, Zyban), mirtazapine (Remeron), nefazodone (Serzone), venlafaxine (Effexor XR), atomoxetine (Strattera)
monoamine oxidase inhibitors (MAOI)
Block an enzyme that breaks down norepinephrine and serotonin, thus prolonging their action; for example, phenelzine (Nardil), tranylcypromine (Parnate), isocarboxazid (Marplan)
neuroleptics
Drugs used to treat psychosis, including schizophrenia; for example, clozapine (Clozaril), haloperidol (Haldol), risperidone (Risperdal), olanzapine (Zyprexa); antipsychotic. Action mechanism unknown, but may interfere with neurotransmitters
selective serotonin reuptake inhibitors (SSRIs)
Block the reuptake of serotonin in the brain, thus increasing levels; for example, fluoxetine (Prozac), citalopram (Celexa), paroxetine (Paxil), sertraline (Zoloft)
stimulants
Promote activity and a sense of well-being; for example, methylphenidate (Ritalin), dextroamphetamine (Dexedrine), amphetamine + dextroamphetamine (Adderall)
tricyclic antidepressants (TCA)
Block the reuptake of norepinephrine, serotonin, or both; for example, amitriptyline (Elavil), clomipramine (Anafril), imipramine (Tofranil), doxepin (Sinequan), trimipramine (Surmontil)
ACh
Acetylcholine
AD
Alzheimer disease
ADHD
Attention-deficit hyperactivity disorder
ALS
Amyotrophic lateral sclerosis
ANS
Autonomic nervous system
BAEP
Brainstem auditory evoked potentials
CBF
Cerebral blood flow
CJD
Creutzfeldt–Jakob disease
CNS
Central nervous system
CP
Cerebral palsy
CSF
Cerebrospinal fluid
CVA
Cerebrovascular accident
CVD
Cerebrovascular disease
DSM
Diagnostic and Statistical Manual of Mental Disorders
DTR
Deep tendon reflexes
EEG
Electroencephalogram; electroencephalograph(y)
GAD
Generalized anxiety disorder
ICP
Intracranial pressure
LMN
Lower motor neuron
LOC
Level of consciousness
LP
Lumbar puncture
MAOI
Monoamine oxidase inhibitor
MID
Multiinfarct dementia
MS
Multiple sclerosis
NICU
Neurological intensive care unit; also neonatal intensive care unit
NPH
Normal pressure hydrocephalus
NREM
Non–rapid eye movement (sleep)
OCD
Obsessive–compulsive disorder
PDD
Pervasive developmental disorder
PET
Positron emission tomography
PNS
Peripheral nervous system
PTSD
Posttraumatic stress disorder
RAS
Reticular activating system
REM
Rapid eye movement (sleep)
SSEP
Somatosensory evoked potentials
SSRI
Selective serotonin reuptake inhibitor
TCA
Tricyclic antidepressant
TIA
Transient ischemic attack
UMN
Upper motor neuron
VEP
Visual evoked potentials