Intro to Cytotoxic Chemotherapy (not finished) Flashcards


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1

Cytotoxic chemotherapy is typically given as part of a

combination regimen in which multiple anticancer agents with different mechanisms of action and toxicities are given together

2

Cytotoxic chemotherapy targets

rapidly proliferating cells (both normal and cancer cells)

3

Cell cycle specific agents affects

dividing cells only (not active on cells in the resting phase)

4

What class is Melphalan

Nitrogen mustard

5

What side effect does Melphalan have

Stomatitis

(treat with ice)

6

What side effects do Cyclophosphamide have

sinus congestion (treat with sudafed), hemorrhagic cystitis (treat with mesna)

7

What subclass is Carmustine and Lomustine

Nitrosureas

8

What side effects do nitrosureas have

pulmonary

(treat with inhaled steroids- can not exceed lifetime max dose)

9

What class is Busulfan

Alkyl sulfonate

10

Side effect of Busulfan

VOD (treat with ursodiol, defibrotide), seizures (treat with keppra)

11

What drugs are in the subclass Triazenes

dacarbazine, temozolomide, procarbazine, altretamine

(class is alkylating agent)

12

Side effect of temozolomide

PJP (prophylaxis-pentamidine)

13

True or false. Temozolomide is a prodrug.

True

14

What interactions do you want to watch out for when taking Mercaptopurine?

allopurinol and milk

15

What is used to prevent harmful effects of Methotrexate

Leucovorin, glucarpidase

16

What can be used for microtubule targeting agents induced peripheral neuropathy?

duloxetine, gabapentin, or pregabalin

17

What can be used to prevent hypersensitivity due to the use of Taxanes

premedicate with steroids

18

Which subclass of medications can be fatal if given intrathecally

Vinca alkaloids

19

Which subclass of medication can cause irreversible total alopecia

Taxanes

20

What gene causes more issues with patients using Camptothecins

UGT1A1*28 (or 6 homozygous alleles)

21

Almost all cytotoxic chemotherapy has

myelosuppression
(expect bleomycin, vincristine, asparaginase)

22

Chemotherapy is _____ and _____ and should be avoided during pregnancy and breastfeeding

teratogenic, mutagenic