Side effects of anticancer drugs Flashcards


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created 1 year ago by taniaharper
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1

What medication has HFS, myelosuppression, and GI side effects (diarrhea and mucositis)

5-FU/Capecitabine

2

How do you treat 5-FU/Capecitabine induced diarrhea?

imodium (loperamide), lomotil (diphenoxylate/atropine)

3

What medication has myelosuppression, nephrotoxicity (dose-related), hepatotoxicity (chronic use), and mucositis?

Methotrexate

4

What subclass of medication has myelosuppression, peripheral neuropathy, fluid retention, alopecia and severe hypersensitivity reactions?

Taxanes

5

What medication has neurotoxicity and myelosuppression?

(whole class are all vesicants)

vincristine

6

What medication has cardiotoxicity, turns urine red and myelosuppression?

Doxorubicin

7

What subclass of medication has acute and delayed diarrhea?

Camptothecins (Irinotecan)

8

How do you treat camptothecins acute and delayed diarrhea?

acute- atropine

delayed- imodium, lomotil

9

What medication has myelosuppression and pulmonary toxicity?

Nitrosureas (carmustine, lomustine)

10

What medication has hemorrhagic cystitis and neurotoxicity?

nitrogen mustards- hemorrhagic cystitis (both)

neurotoxicity- ifosfamide

11

Antidote for Ifosfamide

methylene blue

12

When do you give mesna (chemoprotectant)

with ifosfamide and high doses of cyclophosphamide (>1000 mg/m2)

13

What is the side effect of Cisplatin and Carboplatin

Nephrotoxicity, ototoxicity, and myelosuppression

14

What is the side effect of ALL platinums

hypersensitivity and peripheral neuropathy (cold induced- oxaliplatin)

15

Dose-limiting toxicities for platinums

cisplatin- ototoxicity

carboplatin- thrombocytopenia

oxaliplatin- peripheral neuropathy

16

Bleomycin side effects

pulmonary toxicity, skin toxicity- hyperpigmentation and rash, hypersensitivity